Contacto
Campos de conocimiento
Biología del Desarrollo
Biología Molecular y Celular de Microorganismos, Plantas y Animales
Farmacología
Líneas de investigación
1) Respuesta inmune de pacientes pediátricos infectados con Rickettsia spp. durante la fase aguda
2) Análisis fenotípico y funcional de leucocitos de sangre periférica en niños infectados por el virus del dengue y su correlación con la gravedad de la enfermedad.
3) Análisis comparativo del sistema inmunológico del tiburón Heterodontus francisci.
4) Respuesta inmune en el embarazo y trastornos de la fertilidad
Publicaciones
1. Immunolocalization of sphingolipid catabolism enzymes along the nephron: novel early urinary biomarkers of renal damage. Martha Franco, Agustina Cano-Martínez, María del Pilar Ramos-Godinez, Rebeca López-Marure, Luis Donis-Maturano, José Santamaría Sosa and Rocio Bautista-Pérez. International Journal of Molecular Sciences. Int. J. Mol. Sci. 2023, 24, 16633. https://doi.org/10.3390/ijms242316633
2. Early appearance of functional plasma cells (CD138+CD98+) in non-immunized neonate mice. Orozco-Uribe M, Maqueda-Alfaro R, Hernández-Cázares F, Saucedo-Campos AD, Donis-Maturano L, Calderón-Amador J, Flores-Romo L, Ortiz-Navarrete V, Hernández-Hernández JM.Immunol Lett. 2023 Jul;259:9-20. doi: 10.1016/j.imlet.2023.05.004. Epub 2023 May 22.
3. Rickettsia Vaccine Candidate pVAX1-OmpB24 Stimulates TCD4+INF-γ+ and TCD8+INF-γ+ Lymphocytes in Autologous Co-Culture of Human Cells. Dzul-Rosado K, Donis-Maturano L, Arias-León J, Machado-Contreras J, Valencia-Pacheco G, Panti-Balam C, Balam-Romero J, Ku-González A, Peniche-Lara G, Mosqueda J, Zazueta OE, Lugo-Caballero C, Puerto-Manzano F.
4. Sphingolipid metabolism and its relationship with cardiovascular, renal and metabolic diseases. Hernández-Bello F, Franco M, Pérez-Méndez Ó, Donis-Maturano L, Zarco-Olvera G, Bautista-Pérez R.Arch Cardiol Mex. 2023;93(1):88-95. doi: 10.24875/ACM.21000333.
5. Immune Monitoring of Paediatric Patients Infected with Rickettsia rickettsii, Ehrlichia canis and Coinfected. Garcia-Rosales L, Escarcega-Avila A, Ramirez-Lopez M, Manzanera-Ornelas D, Guevara-Macias E, Vaquera-Arteaga M, Alvarado-Gonzlaez C, Estrada BE, Jimenez-Vega F, Donis-Maturano L, Espino-Solis GP.Pathogens. 2022 Nov 15;11(11):1351. doi: 10.3390/pathogens11111351.
6. Dissemination of Gram-positive bacteria to the lung of newborn mice increases local IL-6 and TNFα levels in lethal bacteremia. Orlando Flores-Maldonado, Gloria M González, Alexandra Montoya, Angel Andrade, Rogelio Treviño-Rangel, Luis Donis-Maturano, Faviola Tavares-Carreón, Miguel A Becerril-García. Microbes Infect 2022 Apr 29;104984. doi: 10.1016/j.micinf.2022.104984.
7. Multi-omics study identifies novel signatures of DNA/RNA, amino acid, peptide, and lipid metabolism by simulated diabetes on coronary endothelial cells. Moreno-Ulloa A, Delgado-De la Herrán HC, Álvarez-Delgado C, Mendoza-Porras O, Carballo-Castañeda RA, Donis-Maturano L, Villarreal F.Sci Rep. 2022 Jul 14;12(1):12027. doi: 10.1038/s41598-022-16300-5.
8. Distinct innate immune responses between sublethal and lethal models of disseminated candidiasis in newborn BALB/c mice. Orlando E Flores-Maldonado , Gloria M González 1, Ángel Andrade-Torres , Rogelio Treviño-Rangel , Luis Donis-Maturano , Aarón Silva-Sánchez , Romel Hernández-Bello , Alexandra Montoya , Rosario Salazar-Riojas , Carolina Romo-González , Miguel A Becerril-García . Microb Pathog. 2021 Sep; 158:105061. doi: 10.1016/j.micpath.2021.105061.
9. Outer Membrane Vesicles From Brucella melitensis Modulate Immune Response and Induce Cytoskeleton Rearrangement in Peripheral Blood Mononuclear Cells. Avila-Calderón ED, Medina-Chávez O, Flores-Romo L, Hernández-Hernández JM, Donis-Maturano L, López-Merino A, Arellano-Reynoso B, Aguilera-Arreola MG, Ruiz EA, Gomez-Lunar Z, Witonsky S, Contreras-Rodríguez A.Front Microbiol. 2020 Oct 19; 11:556795. doi: 10.3389/fmicb.2020.556795. eCollection 2020.
10. Langerhans Cells From Mice at Birth Express Endocytic- and Pattern Recognition-Receptors, Migrate to Draining Lymph Nodes Ferrying Antigen and Activate Neonatal T Cells in vivo. Becerril-García MA, Yam-Puc JC, Maqueda-Alfaro R, Beristain-Covarrubias N, Heras-Chavarría M, Gallegos-Hernández IA, Calderón-Amador J, Munguía-Fuentes R, Donis-Maturano L, Flores-Langarica A, Flores-Romo L.Front Immunol. 2020 Apr 27; 11:744. doi: 10.3389/fimmu.2020.00744. eCollection 2020.
11. Dendritic cells and Brucella spp. interaction: the sentinel host and the stealthy pathogen. Avila-Calderón ED, Flores-Romo L, Sharon W, Donis-Maturano L, Becerril-García MA, Arreola MGA, Reynoso BA, Güemes FS, Contreras-Rodríguez A. Folia Microbiol (Praha). 2019 Feb 19. doi: 10.1007/s12223-019-00691-6.
12. Tamoxifen induces toxicity, causes autophagy, and partially reverses dexamethasone resistance in Jurkat T cells. Torres-López L, Maycotte P, Liñán-Rico A, Liñán-Rico L, Donis-Maturano L, Delgado-Enciso I, Meza-Robles C, Vásquez-Jiménez C, Hernández-Cruz A, Dobrovinskaya O. J Leukoc Biol. 2019 Jan 15. doi: 10.1002/JLB.2VMA0818-328R
13. Marine peptides as immunomodulators: Californiconus californicus-derived synthetic conotoxins induce IL-10 production by regulatory T cells (CD4+Foxp3+). Zazueta-Favela D, Donis-Maturano L, Licea-Navarro AF, Bernáldez-Sarabia J, Dan KWL, Cota-Arce JM, Escobedo G, De León-Nava MA. Immunopharmacol Immunotoxicol. 2019 Jul 24:1-6. doi: 10.1080/08923973.2019.1641114.
