Contacto
Campos de conocimiento
Biología Molecular y Celular de Microorganismos, Plantas y Animales
Ciencias Genómicas
Genética y Fisiología Celular
Líneas de investigación
- Estudio de vías patogénicas en enfermedades autoinmunes
- Mecanismos de tolerancia periférica en la respuesta inmune contra el cáncer
Publicaciones
Rodríguez-Rodríguez N, Madera-Salcedo IK, Bugarin-Estrada E, Sánchez-Miranda E, Torres-García D, Cervantes-Torres J, Fragoso G, Rosetti F, Crispín JC, Sciutto E. The helminth-derived peptide GK-1 induces an anti-tumoral CD8 T cell response associated with downregulation of the PD-1/PD-L1 pathway. Clin Immunol. 2020 Mar;212:108240. Epub 2019 Jul 9.
Madera-Salcedo IK, Sánchez-Hernández BE, Svyryd Y, Esquivel-Velázquez M, Rodríguez-Rodríguez N, Trejo-Zambrano MI, García-González HB, Hernández-Molina G, Mutchinick OM, Alcocer-Varela J, Rosetti F*, Crispín JC*. PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases. JCI Insight. 2019 Jul 23;5. pii: 126457.
*autores de correspondencia
Toro-Domínguez D, Lopez-Domínguez R, García Moreno A, Villatoro-García JA, Martorell-Marugán J, Goldman D, Petri M, Wojdyla D, Pons-Estel BA, Isenberg D, Morales-Montes de Oca G, Trejo-Zambrano MI, García González B, Rosetti F, Gómez-Martín D, Romero-Díaz J, Carmona-Sáez P, Alarcón-Riquelme ME. Differential Treatments Based on Drug-induced Gene Expression Signatures and Longitudinal Systemic Lupus Erythematosus Stratification. Sci Rep. 2019 Oct 29;9(1):15502.
Rodríguez-Rodríguez N, Flores-Mendoza G, Apostolidis SA, Rosetti F, Tsokos GC, Crispín JC. TCR-α/β CD4- CD8- double negative T cells arise from CD8+ T cells.
J Leukoc Biol. 2020, 1-7.
Rodríguez-Rodríguez N, Madera-Salcedo IK, Cisneros-Segura JA, García-González HB, Apostolidis SA, Saint-Martin A, Esquivel-Velázquez M, Nguyen T, Romero-Rodríguez DP, Tsokos GC, Alcocer-Varela J, Rosetti F*, Crispin JC*. Protein phosphatase 2A B55ß limits CD8 T cell lifespan following cytokine withdrawal. J Clin Invest. 2020. 130(11): 5989-6004.
*autores de correspondencia
Flores-Mendoza G, Rodríguez-Rodríguez N, Rubio RM, Madera-Salcedo IK, Rosetti F, Crispín JC. Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens. Front Immunol. 2021 Mar 24;12:635862.
Tapia-Maltos MA, Treviño-Frenk I, García-González HB, Rosetti M, Barriga-Maldonado V, Morales-Ramírez F, López-Hernández DC, Rosetti F, Crispín JC.
Identification of regulatory T cell molecules associated with severity of multiple sclerosis. Mult Scler. 2020 Dec 10:1352458520977045.
Mysore V, Cullere X, Mears J, Rosetti F, Okubo K, Liew PX, Zhang F, Madera-Salcedo I, Rosenbauer F, Stone RM, Aster JC, von Andrian UH, Lichtman AH, Raychaudhuri S, Mayadas TN, FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity. Nat Commun. 2021; 12: 4791.
Sánchez-Navarro A, Martínez-Rojas MÁ, Albarrán-Godinez A, Pérez-Villalva R, Auwerx J, de la Cruz A, Noriega LG, Rosetti F, Bobadilla NA. Sirtuin 7 Deficiency Reduces Inflammation and Tubular Damage Induced by an Episode of Acute Kidney Injury. Int J Mol Sci. 2022;23(5):2573.
Mysore V, Tahir S, Furuhashi K, Arora J, Rosetti F, Cullere X, Yazbeck P, Sekulic M, Lemieux ME, Raychaudhuri S, Horwitz BH, Mayadas TN. Monocytes transition to macrophages within the inflamed vasculature via monocyte CCR2 and endothelial TNFR2. J Exp Med. 2022 May 2;219(5):e20210562.
Madera-Salcedo IK, Ramírez-Sánchez AL, Rodríguez-Rodríguez N, García-Quintero R, Rubio RM, Morales-Montes de Oca G, Dávalos E, Cuervo R, Furuzawa-Carballeda J, Alcocer-Varela J, Gómez-Martín D, González-Yáñez M, de la Cruz A, Albarrán-Godínez A, Suárez-Rojas G, Romero-Díaz J, Uribe-Uribe NO, Alarcón-Riquelme M, Furlan-Magaril M, Mejía-Vilet JM, Crispín JC, Rosetti F. Down-Regulation-Resistant STAT4 Risk Haplotype Contributes to Lupus Nephritis Through CD4+ T Cell Interferon-γ Production. Arthritis Rheumatol.2023. doi 10.1002/art.42435.
Martínez-Rojas MÁ, Balcázar H, González-Soria I, González-Rivera JM, Rodríguez-Vergara ME, Velazquez-Villegas LA, León-Contreras JC, Pérez-Villalva R, Correa F, Rosetti F, Bobadilla NA. Transient inhibition of sodium-glucose cotransporter 2 after ischemia/reperfusion injury ameliorates chronic kidney disease. JCI Insight. 2024 Feb 22;9(6):e173675.
Cisneros-Segura JA, Rodríguez-Rodríguez N, Albarrán-Godínez A, García-González HB, Rodríguez-Osorio CA, Valdés-Ferrer SI, Tapia-Urzúa G, Recillas-Targa F, Madera-Salcedo IK, Rosetti F, Crispín JC. Sepsis Impairs IFN-γ Production in CD8 T Cells through Changes in Local Chromatin Landscape. J Immunol. 2024 Jul 22:ji2300772.
