Mecanismos moleculares que controlan el movimiento de células cancerosas y del estroma tumoral contribuyendo a la diseminación de tumores.
Proteínas multidominio como plataformas de señalización que responden a estímulos relevantes en el microambiente tumoral.
Proteínas multidominio del grupo de RhoGEFs como posibles efectores oncogénicos.
RhoGEFs como potenciales blancos farmacológicos en el cáncer metastásico.
Activación de los switches moleculares que regulan el citoesqueleto de actina.

Publicaciones

Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch.
Bracho-Valdés I, Cervantes-Villagrana RD, Beltrán-Navarro YM, Olguín-Olguín A, Escobar-Islas E, Carretero-Ortega J, Olivares-Reyes JA, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J.
Int J Mol Sci. 2023 Dec 15;24(24):17531. doi: 10.3390/ijms242417531.

Ephexin3/ARHGEF5 Together with Cell Migration Signaling Partners within the Tumor Microenvironment Define Prognostic Transcriptional Signatures in Multiple Cancer Types.
Juan-Guadarrama DG, Beltrán-Navarro YM, Reyes-Cruz G, Vázquez-Prado J.
Int J Mol Sci. 2023 Nov 17;24(22):16427. doi: 10.3390/ijms242216427.

Oncogenic Gαq activates RhoJ through PDZ-RhoGEF.
Cervantes-Villagrana RD, Color-Aparicio VM, Castillo-Kauil A, García-Jiménez I, Beltrán-Navarro YM, Reyes-Cruz G, Vázquez-Prado J.
Int J Mol Sci. 2023 Oct 29;24(21):15734. doi: 10.3390/ijms242115734.

Guanine nucleotide exchange factors for Rho GTPases (RhoGEFs) as oncogenic effectors and strategic therapeutic targets in metastatic cancer.
Cervantes-Villagrana RD, García-Jiménez I, Vázquez-Prado J.
Cell Signal. 2023 Sep;109:110749. doi: 10.1016/j.cellsig.2023.110749. Epub 2023 Jun 7.

P-Rex1 Signaling Hub in Lower Grade Glioma Patients, Found by In Silico Data Mining, Correlates With Reduced Survival and Augmented Immune Tumor Microenvironment.
Beltrán-Navarro YM, Reyes-Cruz G, Vázquez-Prado J.
Front Oncol. 2022 Jul 7;12:922025. doi: 10.3389/fonc.2022.922025. eCollection 2022.

Gβγ mediates activation of Rho guanine nucleotide exchange factor ARHGEF17 that promotes metastatic lung cancer progression.
García-Jiménez I, Cervantes-Villagrana RD, Del-Río-Robles JE, Castillo-Kauil A, Beltrán-Navarro YM, García-Román J, Reyes-Cruz G, Vázquez-Prado J.
J Biol Chem. 2022 Jan;298(1):101440. doi: 10.1016/j.jbc.2021.101440. Epub 2021 Nov 20.

Gβγ recruits and activates P-Rex1 via two independent binding interfaces.
Cervantes-Villagrana RD, Beltrán-Navarro YM, García-Jiménez I, Adame-García SR, Olguín-Olguín A, Reyes-Cruz G, Vázquez-Prado J.
Biochem Biophys Res Commun. 2021 Feb 5;539:20-27. doi: 10.1016/j.bbrc.2020.12.089. Epub 2021 Jan 4.

Gαs directly drives PDZ-RhoGEF signaling to Cdc42.
Castillo-Kauil A, García-Jiménez I, Cervantes-Villagrana RD, Adame-García SR, Beltrán-Navarro YM, Gutkind JS, Reyes-Cruz G, Vázquez-Prado J.
J Biol Chem. 2020 Dec 11;295(50):16920-16928. doi: 10.1074/jbc.AC120.015204. Epub 2020 Oct 6.

Endothelial cell sprouting driven by RhoJ directly activated by a membrane-anchored Intersectin 1 (ITSN1) RhoGEF module.
Color-Aparicio VM, Cervantes-Villagrana RD, García-Jiménez I, Beltrán-Navarro YM, Castillo-Kauil A, Escobar-Islas E, Reyes-Cruz G, Vázquez-Prado J.
Biochem Biophys Res Commun. 2020 Mar 26;524(1):109-116. doi: 10.1016/j.bbrc.2020.01.068. Epub 2020 Jan 21.

Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs.
Cervantes-Villagrana RD, Color-Aparicio VM, Reyes-Cruz G, Vázquez-Prado J.
J Cell Commun Signal. 2019 Jun;13(2):179-191. doi: 10.1007/s12079-018-00502-6. Epub 2019 Jan 5.

Direct targeting of Gαq and Gα11 oncoproteins in cancer cells.
Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, Pfeil EM, Cervantes-Villagrana RD, Inoue A, Häberlein F, Slodczyk T, Reher R, Kehraus S, Monteleone S, Schrage R, Heycke N, Rick U, Engel S, Pfeifer A, Kolb P, König G, Bünemann M, Tüting T, Vázquez-Prado J, Gutkind JS, Gaffal E, Kostenis E.
Sci Signal. 2019 Mar 19;12(573):eaau5948. doi: 10.1126/scisignal.aau5948.

cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits.
Adame-García SR, Cervantes-Villagrana RD, Orduña-Castillo LB, Del Rio JC, Gutkind JS, Reyes-Cruz G, Taylor SS, Vázquez-Prado J.
J Biol Chem. 2019 Feb 15;294(7):2232-2246. doi: 10.1074/jbc.RA118.006691. Epub 2018 Dec 10.

Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins.
Cervantes-Villagrana RD, Adame-García SR, García-Jiménez I, Color-Aparicio VM, Beltrán-Navarro YM, König GM, Kostenis E, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J.
J Biol Chem. 2019 Jan 11;294(2):531-546. doi: 10.1074/jbc.RA118.006254. Epub 2018 Nov 16.

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx