Fisiopatología del síndrome metabólico y su tratamiento con compuestos naturales
Fisiopatología cardiovascular y papel cardioprotector de los fibratos
Papel del sistema renina-angiotensina en enfermedades cardiometabólicas

Publicaciones

Guarner-Lans V, Ramírez-Higuera A, Rubio-Ruiz ME, Castrejón-Téllez V, Soto ME, Pérez-Torres I. Early Programming of Adult Systemic Essential Hypertension. Int J Mol Sci. 2020; 21(4). pii: E1203. doi: 10.3390/ijms21041203.

Castrejón-Téllez V, Villegas-Romero M, Rubio-Ruiz ME, Pérez-Torres I, Carreón-Torres E, Díaz-Díaz E, Guarner-Lans V. Effect of a Resveratrol/Quercetin Mixture on the Reversion of Hypertension Induced by a Short-Term Exposure to High Sucrose Levels Near Weaning and a Long-Term Exposure That Leads to Metabolic Syndrome in Rats. Int J Mol Sci. 2020; 21(6):2231. doi:10.3390/ijms21062231

Pérez-Torres I, Manzano-Pech L, Rubio-Ruíz ME, Soto ME, Guarner-Lans V. Nitrosative Stress and Its Association with Cardiometabolic Disorders.
Molecules. 2020; 25(11):2555. doi: 10.3390/molecules25112555.

I. Pérez-Torres, M. E. Soto, V. Castrejón-Tellez, M. E. Rubio-Ruiz, L. Manzano Pech, and V. Guarner-Lans. Oxidative, Reductive, and Nitrosative Stress Effects on Epigenetics and on Posttranslational Modification of Enzymes in Cardiometabolic Diseases. Oxidative Medicine and Cellular Longevity. Volume 2020, Article ID 8819719, 19 pages. https://doi.org/10.1155/2020/8819719

María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo del Valle-Mondragón, Elizabeth Soria-Castro, Juan Carlos Torres-Narváez, Elizabeth Carreón-Torres, Alicia Sánchez-Mendoza, and María Esther Rubio-Ruíz. Nonclassical Axis of the Renin-Angiotensin System and Neprilysin: Key Mediators That Underlie the Cardioprotective Effect of PPAR-Alpha Activation during Myocardial Ischemia in a Metabolic Syndrome Model.
PPAR Research Volume 2020, Article ID 8894525, 12 pages https://doi.org/10.1155/2020/8894525

Israel Pérez-Torres, Vicente Castrejón-Téllez, María Elena Soto, María Esther Rubio-Ruiz, Linaloe Manzano-Pech, Verónica Guarner-Lans. Oxidative Stress, Plant Natural Antioxidants, and Obesity. Int J Mol Sci. 2021, 11; 22(4):1786. doi: 10.3390/ijms22041786.

Félix Leao Rodríguez-Fierros, Verónica Guarner-Lans, María Elena Soto, Linaloe Manzano-Pech, Eulises Díaz-Díaz, Elizabeth Soria-Castro, María Esther Rubio-Ruiz, Francisco Jiménez-Trejo, Israel Pérez-Torres. Modulation of Renal Function in a Metabolic Syndrome Rat Model by Antioxidants in Hibiscus sabdariffa L. Molecules 2021, 26, 2074. https://doi.org/10.3390/molecules26072074.

Cano-Martínez A, Bautista-Pérez R, Castrejón-Téllez V, Carreón-Torres E, Pérez-Torres I, Díaz-Díaz E, Flores-Estrada J, Guarner-Lans V, Rubio-Ruíz ME. Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome. Int J Mol Sci. 2021; 22(16):8939. doi: 10.3390/ijms22168939.

Saucedo-Orozco H, Torres IP, Vera SAC, Frausto AA, Godínez JAA, Guarner-Lans V, Rubio E, López MES. Correlation Between Cardiac Computed Tomography and Histopathology for Evaluating Patients with Aortic Valve Disease. Acad Radiol. 2022 Apr;29 Suppl 4:S25-S32. doi: 10.1016/j.acra.2020.12.015.
Pérez-Torres I, Soto ME, Manzano-Pech L, Díaz-Diaz E, Soria-Castro E, Rubio-Ruíz ME, Guarner-Lans V. Oxidative Stress in Plasma from Patients with Marfan Syndrome Is Modulated by Deodorized Garlic Preliminary Findings. Oxid Med Cell Longev. 2022; 2022:5492127. doi: 10.1155/2022/5492127.
Soto, M.E.; Pérez-Torres, I.; Rubio-Ruiz, M.E.; Manzano-Pech, L.; Guarner-Lans, V. Interconnection between Cardiac Cachexia and Heart Failure—Protective Role of Cardiac Obesity. Cells 2022, 11, 1039. https:// doi.org/10.3390/cells11061039
Cano-Martínez A, Rubio-Ruiz ME, Guarner-Lans V. Cardiología evolutiva e investigación experimental [Evolutionary cardiology and experimental research]. Arch Cardiol Mex. 2022, 92(3):390-398. doi: 10.24875/ACM.210002751.
Castrejón-Téllez V.; Rubio-Ruiz M.E.; Cano-Martínez A.; Pérez-Torres I.; del Valle- Mondragón L.; Carreón-Torres E.; Guarner-Lans V. High Sucrose Ingestion during a Critical Period of Vessel Development Promotes the Synthetic Phenotype of Vascular Smooth Muscle Cells and Modifies Vascular Contractility Leading to Hypertension in Adult Rats. Int. J. Hyper. Volume 2022, Article ID 2298329, 10.1155/2022/2298329.
Soto, M.E.; Pérez-Torres, I.; Rubio-Ruiz, M.E.; Cano-Martínez, A.; Manzano-Pech, L.; Guarner-Lans, V. Frailty and the Interactions between Skeletal Muscle, Bone, and Adipose Tissue. Impact on Cardiovascular Disease and Possible Therapeutic Measures. Int. J. Mol. Sci. 2023, 24, 4534. https://doi.org/10.3390/ijms24054534
Sánchez-Aguilar, M.; Ibarra-Lara, L.; Cano-Martínez, A.; Soria-Castro, E.; Castrejón-Téllez, V.; Pavón, N.; Osorio-Yáñez, C.; Díaz-Díaz, E.; Rubio-Ruíz, M.E. PPAR Alpha Activation by Clofibrate Alleviates Ischemia/Reperfusion Injury in Metabolic Syndrome Rats by Decreasing Cardiac Inflammation and Remodeling and by Regulating the Atrial Natriuretic Peptide Compensatory Response. Int. J. Mol. Sci. 2023, 24, 5321. https://doi.org/ 10.3390/ijms24065321
Flores-Estrada, J.; Cano-Martínez, A.; Vargas-González, Á.; Castrejón-Téllez, V.; Cornejo-Garrido, J.; Martínez-Rosas, M.; Guarner-Lans, V.; Rubio-Ruíz, M.E. Hepatoprotective Mechanisms Induced by Spinach Methanolic Extract in Rats with Hyperglycemia—An Immunohistochemical Analysis. Antioxidants 2023, 12, 2013. https://doi.org/10.3390/antiox12112013
Cano-Martínez A, Rubio-Ruiz ME, Guarner-Lans V. Homeostasis and evolution in relation to regeneration and repair. J Physiol. 2024 Jun; 602(11):2627-2648. doi: 10.1113/JP284426.
Rubio-Ruíz ME, Plata-Corona JC, Soria-Castro E, Díaz-Juárez JA, Sánchez-Aguilar M. Pleiotropic Effects of Peroxisome Proliferator-Activated Receptor Alpha and Gamma Agonists on Myocardial Damage: Molecular Mechanisms and Clinical Evidence-A Narrative Review. Cells. 2024 Sep 5;13(17):1488. doi: 10.3390/cells13171488.
Guarner-Lans, V.; Soria-Castro, E.; Cano-Martínez, A.; Rubio-Ruiz, M.E.; Zarco, G.; Carreón-Torres, E.; Grimaldo, O.; Castrejón-Téllez, V.; Pérez-Torres, I. Rats Exposed to Excess Sucrose During a Critical Period Develop Inflammation and Express a Secretory Phenotype of Vascular Smooth Muscle Cells. Metabolites 2024, 14, 555. doi:10.3390/metabo14100555
Ramírez-Melo LM, Estrada-Luna D, Rubio-Ruiz ME, Castañeda-Ovando A, Fernández-Martínez E, Jiménez-Osorio AS, Pérez-Méndez Ó, Carreón-Torres E. Relevance of Lipoprotein Composition in Endothelial Dysfunction and the Development of Hypertension. Int J Mol Sci. 2025 Jan 28;26(3):1125. doi: 10.3390/ijms26031125.

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx