Contacto
Campos de conocimiento
Bioquímica
Biotecnología
Reconocimiento Molecular y Bioestructura
Líneas de investigación
Generación de Anticuerpos Recombinantes como Antivenenos.
Publicaciones
81. Delgado-Prudencio,G. Possani,L.D. Becerril,B. Ortiz,E. 2019. The Dual alpha-Amidation System in Scorpion Venom Glands Toxins (Basel), 11, 425.
82. Ruiz-Zamora,R.A. Guillaume,S. Al-Hilaly,Y.K. Al-Garawi,Z. Rodriguez-Alvarez,F.J. Zavala-Padilla,G. Perez-Carreon,J.I. Rodriguez-Ambriz,S.L. Herrera,G.A. Becerril-Lujan,B. Ochoa-Leyva,A. Melendez-Zajgla,J. Serpell,L. Del Pozo-Yauner,L. 2019. The CDR1 and Other Regions of Immunoglobulin Light Chains are Hot Spots for Amyloid Aggregation Scientific Reports, 9, 3123.
83. Riano-Umbarila,L. Gomez-Ramirez,I.V. Ledezma-Candanoza,L.M. Olamendi-Portugal,T. Rodriguez-Rodriguez,E.R. Fernandez-Taboada,G. Possani,L.D. Becerril,B. 2019. Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms Toxins (Basel), 11, 32.
84. Riano-Umbarila,L. Rojas-Trejo,V.M. Romero-Moreno,J.A. Costas,M. Utrera-Espindola,I. Olamendi-Portugal,T. Possani,L.D. Becerril,B. 2020. Comparative assessment of the VH-VL and VL-VH orientations of single-chain variable fragments of scorpion toxin-neutralizing antibodies Molecular Immunology, 122, 141-147.
85. Lopez-Giraldo,A.E., Olamendi-Portugal,T., Riano-Umbarila,L., Becerril,B., Possani,L.D., Delepierre,M., Rio-Portilla,F.D. (2020). The three-dimensional structure of the toxic peptide Cl13 from the scorpion Centruroides limpidus. Toxicon, 184, 158-166.
86. Gomez-Ramirez,I.V., Riano-Umbarila,L., Olamendi-Portugal,T., Restano-Cassulini,R., Possani,L.D., Becerril,B. (2020). Biochemical, electrophysiological and immunological characterization of the venom from Centruroides baergi, a new scorpion species of medical importance in Mexico. Toxicon, 184, 10-18.
87. Jimenez-Vargas,J.M., Ramirez-Carreto,S., Corzo,G., Possani,L.D., Becerril,B., Ortiz,E. (2021). Structural and functional characterization of NDBP-4 family antimicrobial peptides from the scorpion Mesomexovis variegatus. Peptides, 141, 170553.
88. Riano-Umbarila,L., Romero-Moreno,J.A., Ledezma-Candanoza,L.M., Olamendi-Portugal,T., Possani,L.D., Becerril,B. (2021). Full Neutralization of Centruroides sculpturatus Scorpion Venom by Combining Two Human Antibody Fragments. Toxins, 13 (10), 708.
89. Fernandez-Taboada,G., Riano-Umbarila,L., Olvera-Rodriguez,A., Gomez-Ramirez,I.V, Losoya-Uribe,L., Becerril,B. (2021). The venom of the scorpion Centruroides limpidus, which causes the highest number of stings in Mexico, is neutralized by two recombinant antibody fragments. Molecular Immunology, 137, 247-255.
90. Hugo Valencia-Martínez, Timoteo Olamendi-Portugal, Rita Restano Cassulini, Hugo Serrano-Posada, Fernando Zamudio, Lourival D. Possani, Lidia Riaño-Umbarila, Baltazar Becerril.Characterization of Four Medically Important Toxins from Centruroides huichol Scorpion Venom and Its Neutralization by a Single Recombinant Antibody Fragment. Toxins 2022, 14(6), 369; https://doi.org/10.3390/toxins14060369 (registering DOI).
91. Gómez-Ramirez,I.V., Corrales-Garcia,L.L., Possani,L.D., Riaño-Umbarila,L y Becerril,B. (2023). Expression in Pichia pastoris of human antibody fragments that neutralize venoms of Mexican scorpions. Toxicon, 223, 107012.
92. José Alberto Romero-Moreno, Hugo Serrano-Posada, Timoteo Olamendi-Portugal, Lourival D. Possani, Baltazar Becerril y Lidia Riaño-Umbarila. Development of a human antibody fragment cross-neutralizing scorpion toxins. Molecular Immunology 155 (2023) 165–174. https://doi.org/10.1016/j.molimm.2023.02.006.
93. Kashmala Shakeel, Timoteo Olamendi-Portugal, Muhammad Umair Naseem , Baltazar Becerril, Fernando Z. Zamudio, Gustavo Delgado-Prudencio, Lourival Domingos Possani,and Gyorgy Panyi. Of Seven New K+ Channel Inhibitor Peptides of Centruroides bonito, α-KTx 2.24 Has a Picomolar Affinity for Kv1.2. Toxins 2023, 15, 506. https://doi.org/10.3390/toxins15080506
94. Olivares-Hernandez,R., Riano-Umbarila,L., Becerril,B., Alagon-Cano,A., Vazquez-Lopez,H. (2024). Pharmacokinetic evaluation of a single chain antibody fragment against scorpion toxins in sheep. Toxicon, 242, 107691.
95. Restano-Cassulini,R., Olamendi-Portugal,T., Riano-Umbarila,L., Zamudio,F.Z., Delgado-Prudencio,G., Becerril,B., Possani,L.D. (2024). Characterization of Sodium Channel Peptides Obtained from the Venom of the Scorpion Centruroides bonito. Toxins (Basel), 16 (3), 125.
96. Lidia Riaño-Umbarila,Timoteo Olamendi-Portugal,José Alberto Romero-Moreno,Gustavo Delgado-Prudencio,Fernando Z. Zamudio,Baltazar Becerril andLourival D. Possani. Toxic Peptides from the Mexican Scorpion Centruroides villegasi: Chemical Structure and Evaluation of Recognition by Human Single-Chain Antibodies. Toxins 2024, 16(7), 301; https://doi.org/10.3390/toxins16070301.
