El interés de nuestro laboratorio es investigar los mecanismos que conducen a la muerte neuronal en condiciones que mimetizan la isquemia cerebral y la hipoglucemia, con énfasis en la participación del estrés oxidante, el estrés del retículo endoplásmico y la autofagia. Utilizamos modelos in vivo e in vitro (cultivos de neuronas y astrocitos) de privación de glucosa/hipoglucemia y de privación de oxígeno y glucosa. También estudiamos el papel protector de los cuerpos cetónicos ante estas respues

Publicaciones

63. Rivero-Segura, N., Coronado-Mares, Ma. I., Rincón-Heredia, R., Pérez–Torres, I., Montiel, T., Pavón, N., Cabrera-Reyes, E.A., Massieu, L., Cerbón, M. (2019). Prolactin prevents mitochondrial dysfunction induced by glutamate excitotoxicity in hippocampal neurons. Neurosci. Lett. 70, 58-64. Impacto 3.04
64. Hernández-Espinosa, D.R., Massieu, L., Montiel, T., Morán, J. (2019). Role of NADPH oxidase-2 in the progression of the inflammatory response secondary to striatum excitotoxic damage. J. Neuroinflammation, 16: 91. https://doi.org/10.1186/s12974-019-1478-4 ISSN: 1742-2094. Impacto 8.32
65. Languren, G., Montiel, T., Ramírez-Lugo, L., Balderas, I., Sánchez-Chávez, G., Sotres-Bayón, F., Bermúdez-Rattoni, F., Massieu, L. (2019). Recurrent moderate hypoglycemia exacerbates oxidative damage and neuronal death leading to cognitive dysfunction after the hypoglycemic coma. J. Cereb. Blood Flow and Metab. 39, 808-821. DOI: 10.1177/0271678X17733640. Impacto 6.2
66. Moreno-Blas, D., Gorostieta-Salas, E., Pommer-Alba, A., Muciño-Hernández, G., Gerónimo-Olvera, G., Maciel-Barón, L.A., Konigsberg, M., Massieu, L., Castro-Obregón, S. (2019). Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy. Aging, 11, 16. 116175-6198 doi: 10.18632/aging.102181. Impacto 5.95
67. Gerónimo-Olvera, C., Massieu, L. (2019). Autophagy as a homeostatic mechanism in response to stress conditions in the central nervous system. Mol Neurobiol. doi.org/10.1007/s12035-019-1546-x. Impacto 5.57
68. Camberos-Luna, L., Massieu, L. (2020). Therapeutic strategies for ketosis induction and their potential efficacy for the treatment of acute brain injury and neurodegenerative diseases. Neurochem. Int. 133. 104614 DOI: 10.1016/j.neuint.2019.104614 Impacto 4.29
69. Montiel, T., Montes-Ortega, L., Massieu, L. (2020). Treatment with the ketone body D-β-hydroxybutyrate attenuates autophagy activated by NMDA and reduces excitotoxic neuronal damage in the rat striatum in vivo. Current Pharmaceutical Design, 26, 1-11. DOI: 10.2174/1381612826666200115103646. Impacto 3.11
70. Torres-Esquivel, C., Montiel, T., Flores-Méndez, Massieu, L. (2020). Effect of β-hydroxybutyrate on autophagy dynamics during severe hypoglycemia and the hypoglycemic coma. Front Cell Neurosci. 23, 14:547215. doi: 10.3389/fncel.2020.547215. Impacto 5.78
71. Peláez Coyotl, E.A., Barrios, Palacios J., Muciño, G., Moreno-Blas, D., Costas, M., Montiel, T., Diener, C., Uribe-Carvajal, S., Massieu, L., Castro-Obregón, S., Ramos Espinosa, O., Mata Espinosa, D., Barrios-Payán, J., León Contreras, J.C., Corzo, G., Hernández-Pando, R., Del Río, G (2020). Antimicrobial peptide against mycobacterium tuberculosis that activates autophagy is an effective treatment for tuberculosis. Pharmaceutics, 12, 1071; doi:10.3390/pharmaceutics12111071. Impacto 4.8
72. Gómora-García, J,C., Gerómino-Olvera, C., Massieu, L. (2021). IRE1α RIDD activity induced under ER stress drives neuronal death by the degradation of 14-3-3 θ mRNA in cortical neurons during glucose deprivation. Cell Death Discovery, 7, 131. Impacto 6.54
73. Klionsky, D.J., Abdel-Aziz, A.K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel S., Abeliovich, H., Abildgaard, M.H., Abudu, Y.P., Acevedo-Arozena, A., Adamopoulos L.E., Adeli, K., Adolph, T.E., Adornetto, A., Aflaki, E., Agam, G., Agarwal, A., Aggarwal, B.B., Agnello, M Tong, C.K. et al. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17:1, 1-382, DOI: 10.1080/15548627.2020.1797280. Impacto 16.06.
74. Morales-Rosales, S.L., Santín-Márquez, R., Posadas-Rodríguez, P., Rincón-Heredia, R., Montiel, T., Librado-Osorio, R., Luna-López, A., Rivero-Segura, N.A., Torres, C., Cano-Martínez, A., Silva-Palacios, A., Cortés-Hernández, P., Morán, J., Massieu, L., Konigsberg M. (2021). Senescence in primary rat astrocytes induces loss of the mitochondrial membrane potential and alters mitochondrial dynamics in cortical neurons. Front. Aging. Neurosci. 766-306. https://doi.org/10.3389/fnagi.2021.766306. Impacto 4.5
75. Tovar y Romo, L., Massieu, L., Arias, C. (2021). Ricardo Tapia (1940-1921). Obituary. J. Neurochem. DOI: 10.1111/jnc.15526. Impacto 5.54
76. Monterrubio‐Ledezma, F., Navarro‐García, F., Massieu, L., Mondragón‐Flores, R., Soto‐Ponce, L.A., Magaña, J.J., Cisneros, B. (2023). Rescue of mitochondrial function in Hutchinson‐Gilford progeria syndrome by the pharmacological modulation of exportin CRM1. Cells, 12, 275. https://doi.org/10.3390/cells12020275. Impacto 7.66
77. Gómora-García, JC., Montiel, T., Hüttenrauch, M., Salcido-Gómez, A., García-Velázquez, L., Ramiro-Cortés, Y., Castro-Obregón, S., Massieu, L. (2023). Effect of the ketone body, D-b-hydroxybutyrate on sirtuin2-mediated regulation of mitochondrial quality control and the autophagy–lysosomal pathway. Cells, 12, 486, https://doi.org/10.3390/cells12030486. Impacto 7.66
78. Montiel, T., Gómora-García, J.C., Gerónimo-Olvera, C., Heras-Romero, Y., Bernal-Vicente, B.N., Pérez-Martínez, X., Tovar-y-Romo, L.B., Massieu, L. (2023). Modulation of the autophagy-lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke. J. Neurochem. 166, 87-106, https://doi.org/10.1111/jnc.15852. Impacto 5.54
79. García-Velázquez, L., Massieu L. (2023). The proteomic effects of ketone bodies: implications for proteostasis and brain proteinopathies. Front. Mol. Neurosci. 16, 1214092, https:/ /10.3389/fnmol.2023.1214092. Impacto 6.7
80. Castillo-Vazquez, SK., Massieu, L., Rincón-Heredia, R., García-delaTorre, P., Quiroz-Baez, R., Gomez-Verjan, JC., N Rivero-Segura, NA. Glutamatergic Neurotransmission in Aging and Neurodegenerative Diseases: A Potential Target to Improve Cognitive Impairment in Aging. (2024) Arch. Med. Res. 103039. Impacto 4.7

Circuito de Posgrado, Ciudad Universitaria
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mdcbq@posgrado.unam.mx