Contacto
Líneas de investigación
Mecanismos de muerte neuronal programada.
Papel de las especies reactivas de oxígeno en la muerte y diferenciación neuronal.
Papel de la NADPH-oxidasa en la muerte y desarrollo neuronal.
Publicaciones
Benítez-Rangel E., Olguín-Albuerne M., López-Méndez M.C., Domínguez-Macouzet G., Guerrero-Hernández A. and Morán J. Caspase-3 activation correlates with the initial mitochondrial membrane depolarization in neonatal cerebellar granule neurons. Frontiers in Cell and Developmental Biology 8:544. doi: 10.3389/fcell.2020.00544 (2020).
Altamirano-Bustamante NF, Garrido-Magaña E, Morán E, Calderón A, Pasten-Hidalgo K,
Castillo-Rodríguez RA, Rojas G, Lara-Martínez R., Leyva-García E., Larralde-Laborde M.,
Domínguez-Macouzet G., Murata Ch., Margarita-Vázquez Y., Payro R., Barbosa M., Valderrama A., Montesinos H., Domínguez-Camacho A., García-Olmos V., Ferrer R., Medina-Bravo P., Santoscoy F., Revilla-Monsalve C., Jiménez-García L.F., Morán J., Vilalobos-Alva J., Villalobos M.J., Calzada-León R., Altamirano P., Altamirano-Bustamante M. Protein-conformational diseases in childhood: Naturally occurring hIAPP amyloid-oligomers and early β-
cell damage in obesity and diabetes. PLoS ONE 15(8): e0237667. https://doi.org/10.1371/journal.pone.0237667 (2020).
Rodriguez-Chavez V, Gladys Molina-Salinas, Wendy Andrea Zepeda-Ruiz, Maria Carmen Rodriguez, Julio Moran, Ofir Picazo, Marco Cerbon. Participation of glutamatergic ionotropic receptors in excitotoxicity: the neuroprotective role of prolactin. Neuroscience. 2021 May 1;461:180-193. doi: 10.1016/j.neuroscience.2021.02.027
Cid-Castro C. and Morán J. Differential ROS-mediated phosphorylation of Drp1 in mitochondrial fragmentation induced by distinct apoptotic stimuli in cerebellar granule neurons. Oxidative Medicine and Cellular Longevity. 2021 Apr 13;2021:8832863. doi: 10.1155/2021/8832863. eCollection 2021.
Morales-Rosales SL, Santín-Márquez R, Posadas-Rodríguez P, Rincon-Heredia R, Montiel T, Librado-Osorio R, Luna-López A, Rivero-Segura NA, Torres C, Cano-Martínez A, Silva-Palacios A, Cortés-Hernández P, Morán J, Massieu L, Konigsberg M. Senescence in primary rat astrocytes induces loss of the 1 mitochondrial membrane potential and alters mitochondrial dynamics in cortical neurons. Frontiers in Aging Neuroscience. 13:766306 doi.org/10.3389/fnagi.2021.766306. 2021.
García- Hernández B and J. Moran. Txnip expression promotes JNK-mediated neuronal death in response to reactive oxygen species. Frontiers in Molecular Neuroscience. Vol. 16, 2023 https://doi.org/10.3389/fnmol.2023.1210962 (2023).
Sánchez-Torres, S., Orozco-Barrios, C., Salgado-Ceballos, H., Segura-Uribe, J., Guerra-Araiza, C. Morán, J. and Coyoy-Salgado, A. Tibolone improves locomotor function in a rat spinal cord injury model by modulating apoptosis and autophagy. International Journal of Molecular Sciences, 24(20), 15285. https://doi.org/10.3390/ijms242015285 (2023).
Mora-Zenil J and Morán J. ROS produced by NOX promote the neurite growth in a PI3K/Akt independent manner. J. Neurosci. Res. 00, 1–19. https://doi.org/10.1002/jnr.25259 (2023)
Jimenez-Vazquez, I.N., Espitia-Pinzon C.I, Negrete-Abasca, l. E., Benítez-Guzmán A., Morán, J. and Gutierrez-Pabello J. Á. Mycobacterium bovis CFE proteins induces apoptosis in a caspase independent manner. Veterinaria México OA, 10. https://doi.org/10.22201/fmvz.24486760e.2023.1195 (2023).
Martínez-Torres A and Moran J. Aquaporin 4 and the Endocannabinoid System: A potential therapeutic target in brain injury. Experimental Brain Research. https://doi.org/10.1007/s00221-024-06896-7 (2024).
Medina-Ruíz, G. I., Medina-Ruiz, A. I. y Morán, J. Fraping: A computational tool for detecting slight differences in fluorescence recovery after photobleaching (FRAP) data for actin polymerization analysis. Microscopy Research and Technique 87(7): 1541-1551. https://doi.org/10.1002/jemt.24533 (2024).
Martínez-Torres A. and Moran J. CB1 receptor activation provides neuroprotection in an animal model of glutamate-induced excitotoxicity through a reduction of NOX-2 activity and oxidative stress. CNS Neuroscience & Therapeutics 30:e70099 (11): 1-17 https://doi.org/10.1111/cns.70099 (2024).
