Acceso a usuarios
Bienvenid@

Tutores

LOURIVAL DOMINGOS POSSANI POSTAY

Instituto de Biotecnología (IBT)

Contacto

Teléfono: 777 3171209
Email: possani@ibt.unam.mx
Sitio web: Visitar sitio web

Campos de conocimiento

Biofísica
Bioquímica
Farmacología
Reconocimiento Molecular y Bioestructura

Líneas de investigación

Caracterización química y funcional de toxinas del veneno de alacranes. Canales iónicos y sus funciones en células excitables y no excitables

Publicaciones

343. Carcamo-Noriega, E. N., Olamendi-Portugal, T., Restano-Cassulini, R., Rowe, A., Uribe-Romero, S. J., Becerril, B., & Possani, L. D. (2018). Intraspecific variation of Centruroides sculpturatus scorpion venom from two regions of Arizona. Archives of Biochemistry and Biophysics, 638, 52-57. doi:10.1016/j.abb.2017.12.012
344. Batista, C. V. F., Martins, J. G., Restano-Cassulini, R., Coronas, F. I. V., Zamudio, F. Z., Procopio, R., & Possani, L. D. (2018). Venom characterization of the Amazonian scorpion Tityus metuendus. Toxicon, 143, 51-58. doi:10.1016/j.toxicon.2018.01.006
345. Ortiz, E., & Possani, L. D. (2018). Scorpion toxins to unravel the conundrum of ion channel structure and functioning. Toxicon, 150, 17-27. doi:10.1016/j.toxicon.2018.04.032
346. Valdez-Velazquez, L. L., Olamendi-Portugal, T., Restano-Cassulini, R., Zamudio, F. Z., & Possani, L. D. (2018). Mass fingerprinting and electrophysiological analysis of the venom from the scorpion Centruroides hirsutipalpus (Scorpiones: Buthidae). Journal of Venomous Animals and Toxins Including Tropical Diseases, 24, 17. doi:10.1186/s40409-018-0154-y
347. Cid-Uribe, J. I., Santibanez-Lopez, C. E., Meneses, E. P., Batista, C. V. F., Jimenez-Vargas, J. M., Ortiz, E., & Possani, L. D. (2018). The diversity of venom components of the scorpion species Paravaejovis schwenkmeyeri (Scorpiones: Vaejovidae) revealed by transcriptome and proteome analyses. Toxicon, 151, 47-62. doi:10.1016/j.toxicon.2018.06.085
348. Banerjee, S., Gnanamani, E., Lynch, S. R., Zuniga, F. Z., Jimenez-Vargas, J. M., Possani, L. D., & Zare, R. N. (2018). An Alkaloid from Scorpion Venom: Chemical Structure and Synthesis. Journal of Natural Products, 81(8), 1899-1904. doi:10.1021/acs.jnatprod.8b00527
349. Veytia-Bucheli, J. I., Jimenez-Vargas, J. M., Melchy-Perez, E. I., Sandoval-Hernandez, M. A., Possani, L. D., & Rosenstein, Y. (2018). Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4(+) effector memory T cell response to TCR stimulation. Cell Commun Signal, 16(1), 45. doi:10.1186/s12964-018-0257-7
350. Arora, A. K., Pesko, K. N., Quintero-Hernandez, V., Possani, L. D., Miller, T. A., & Durvasula, R. V. (2018). A paratransgenic strategy to block transmission of Xylella fastidiosa from the glassy-winged sharpshooter Homalodisca vitripennis. BMC Biotechnology, 18(1), 50. doi:10.1186/s12896-018-0460-z
351. Gonzalez-Santillan, E., & Possani, L. D. (2018). North American scorpion species of public health importance with a reappraisal of historical epidemiology. Acta Tropica, 187, 264-274. doi:10.1016/j.actatropica.2018.08.002
352. Olamendi-Portugal, T., Batista, C. V. F., Pedraza-Escalona, M., Restano-Cassulini, R., Zamudio, F. Z., Benard-Valle, M., de Roodt, A. R., & Possani, L. D. (2018). New insights into the proteomic characterization of the coral snake Micrurus pyrrhocryptus venom. Toxicon, 153, 23-31. doi:10.1016/j.toxicon.2018.08.003
353. Romero-Gutierrez, M. T., Santibáñez-López, C. E., Jiménez-Vargas, J. M., Batista, C. V. F., Ortiz, E., & Possani, L. D. (2018). Transcriptomic and proteomic analyses reveal the diversity of venom components from the vaejovid scorpion Serradigitus gertschi. Toxins, 10(9), 359. doi:10.3390/toxins10090359
354. Carcamo-Noriega, E. N., Possani, L. D., & Ortiz, E. (2019). Venom content and toxicity regeneration after venom gland depletion by electrostimulation in the scorpion Centruroides limpidus. Toxicon, 157, 87-92. doi:10.1016/j.toxicon.2018.11.305
355. Riaño-Umbarila, L., Gómez-Ramírez, I. V., Ledezma-Candanoza, L. M., Olamendi-Portugal, T., Rodríguez-Rodríguez, E. R., Fernández-Taboada, G., Possani, L. D., & Becerril, B. (2019). Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms. Toxins, 11(1), 32. doi:10.3390/toxins11010032
356. Bernaldez-Sarabia, J., Figueroa-Montiel, A., Duenas, S., Cervantes-Luevano, K., Beltran, J. A., Ortiz, E., Jimenez, S., Possani, L. D., Paniagua-Solis, J. F., Gonzalez-Canudas, J., & Licea-Navarro, A. (2019). The Diversified O-Superfamily in Californiconus californicus Presents a Conotoxin with Antimycobacterial Activity. Toxins, 11(2), 128. doi:10.3390/toxins11020128
357. Okada, M., Ortiz, E., Corzo, G., & Possani, L. D. (2019). Pore-forming spider venom peptides show cytotoxicity to hyperpolarized cancer cells expressing K+ channels: A lentiviral vector approach. PloS One, 14(4), e0215391. doi:10.1371/journal.pone.0215391
358. Cid-Uribe, J. I., Meneses, E. P., Batista, C. V. F., Ortiz, E., & Possani, L. D. (2019). Dissecting toxicity: the venom gland transcriptome and the venom proteome of the highly venomous scorpion Centruroides limpidus (Karsch, 1879). Toxins, 11(5), 247. doi:10.3390/toxins11050247
359. Jauregui-Zuniga, D., Pedraza-Escalona, M., Merino-Guzman, R., & Possani, L. D. (2019). Construction and expression of a single-chain variable fragment antibody against chicken DEC 205 for targeting the bacterial expressed hemagglutinin-neuraminidase of Newcastle disease virus. Veterinary Immunology and Immunopathology, 212, 9-14. doi:10.1016/j.vetimm.2019.05.001
360. Carcamo-Noriega, E. N., Sathyamoorthi, S., Banerjee, S., Gnanamani, E., Mendoza-Trujillo, M., Mata-Espinosa, D., Hernandez-Pando, R., Veytia-Bucheli, J. I., Possani, L. D., & Zare, R. N. (2019). 1,4-Benzoquinone antimicrobial agents against Staphylococcus aureus and Mycobacterium tuberculosis derived from scorpion venom. Proceedings of the National Academy of Sciences of the United States of America, 116(26), 12642-12647. doi:10.1073/pnas.1812334116
361. Gurrola, G. B., Guijarro, J. I., Delepierre, M., Mendoza, R. L. L., Cid-Uribe, J. I., Coronas, F. V., & Possani, L. D. (2019). Cn29, a novel orphan peptide found in the venom of the scorpion Centruroides noxius: Structure and function. Toxicon, 167, 184-191. doi:10.1016/j.toxicon.2019.06.013
362. Delgado-Prudencio, G., Possani, L. D., Becerril, B., & Ortiz, E. (2019). The dual alpha-amidation system in scorpion venom glands. Toxins, 11(7), 425. doi:10.3390/toxins11070425
363. Rincón-Cortés, C. A., Olamendi-Portugal, T., Carcamo-Noriega, E. N., Santillan, E. G., Zuniga, F. Z., Reyes-Montano, E. A., Vega Castro, N. A., & Possani, L. D. (2019). Structural and functional characterization of toxic peptides purified from the venom of the Colombian scorpion Tityus macrochirus. Toxicon, 169, 5-11. doi:10.1016/j.toxicon.2019.07.013
364. Santibáñez-López, C. E., Graham, M. R., Sharma, P. P., Ortiz, E., & Possani, L. D. (2019). Hadrurid scorpion toxins: evolutionary conservation and selective pressures. Toxins, 11(11), 637. doi:10.3390/toxins11110637
365. El-Bitar, A. M. H., Sarhan, M., Abdel-Rahman, M. A., Quintero-Hernandez, V., Aoki-Utsubo, C., Moustafa, M. A., Possani, L. D., & Hotta, H. (2020). Smp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus. International Journal of Peptide Research and Therapeutics, 26(2), 811-821. doi:10.1007/s10989-019-09888-2
366. Garcia-Guerrero, I. A., Carcamo-Noriega, E., Gomez-Lagunas, F., Gonzalez-Santillan, E., Zamudio, F. Z., Gurrola, G. B., & Possani, L. D. (2020). Biochemical characterization of the venom from the Mexican scorpion Centruroides ornatus, a dangerous species to humans. Toxicon, 173, 27-38. doi:10.1016/j.toxicon.2019.11.004
367. Cid-Uribe, J. I., Veytia-Bucheli, J. I., Romero-Gutierrez, T., Ortiz, E., & Possani, L. D. (2020). Scorpion venomics: a 2019 overview. Expert Review of Proteomics, 17(1), 67-83. doi:10.1080/14789450.2020.1705158
368. Luna-Ramirez, K., Csoti, A., McArthur, J. R., Chin, Y. K. Y., Anangi, R., Najera, R. D. C., Possani, L. D., King, G. F., Panyi, G., Yu, H., Adams, D. J., & Finol-Urdaneta, R. K. (2020). Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom. Biochemical Pharmacology, 174, 113782. doi:10.1016/j.bcp.2019.113782
369. Valdez-Velázquez, L. L., Cid-Uribe, J., Romero-Gutierrez, M. T., Olamendi-Portugal, T., Jimenez-Vargas, J. M., & Possani, L. D. (2020). Transcriptomic and proteomic analyses of the venom and venom glands of Centruroides hirsutipalpus, a dangerous scorpion from Mexico. Toxicon, 179, 21-32. doi:10.1016/j.toxicon.2020.02.021
370. Riaño-Umbarila, L., Rojas-Trejo, V. M., Romero-Moreno, J. A., Costas, M., Utrera-Espindola, I., Olamendi-Portugal, T., Possani, L. D., & Becerril, B. (2020). Comparative assessment of the VH-VL and VL-VH orientations of single-chain variable fragments of scorpion toxin-neutralizing antibodies. Molecular Immunology, 122, 141-147. doi:10.1016/j.molimm.2020.04.015
371. Cota-Arce, J. M., Zazueta-Favela, D., Diaz-Castillo, F., Jimenez, S., Bernaldez-Sarabia, J., Caram-Salas, N. L., Dan, K. W. L., Escobedo, G., Licea-Navarro, A. F., Possani, L. D., & De Leon-Nava, M. A. (2020). Venom components of the scorpion Centruroides limpidus modulate cytokine expression by T helper lymphocytes: Identification of ion channel-related toxins by mass spectrometry. International Immunopharmacology, 84, 106505. doi:10.1016/j.intimp.2020.106505
372. Gomez-Ramirez, I. V., Riano-Umbarila, L., Olamendi-Portugal, T., Restano-Cassulini, R., Possani, L. D., & Becerril, B. (2020). Biochemical, electrophysiological and immunological characterization of the venom from Centruroides baergi, a new scorpion species of medical importance in Mexico. Toxicon, 184, 10-18. doi:10.1016/j.toxicon.2020.05.021
373. Benard-Valle, M., Neri-Castro, E., Yanez-Mendoza, M. F., Lomonte, B., Olvera, A., Zamudio, F., Restano-Cassulini, R., Possani, L. D., Jimenez-Ferrer, E., & Alagon, A. (2020). Functional, proteomic and transcriptomic characterization of the venom from Micrurus browni browni: Identification of the first lethal multimeric neurotoxin in coral snake venom. Journal of Proteomics, 225, 103863. doi:10.1016/j.jprot.2020.103863
374. Lopez-Giraldo, A. E., Olamendi-Portugal, T., Riano-Umbarila, L., Becerril, B., Possani, L. D., Delepierre, M., & Del Rio-Portilla, F. (2020). The three-dimensional structure of the toxic peptide Cl13 from the scorpion Centruroides limpidus. Toxicon, 184, 158-166. doi:10.1016/j.toxicon.2020.06.011
375. Neri-Castro, E., Benard-Valle, M., Paniagua, D., Boyer, L. V., Possani, L. D., Lopez-Casillas, F., Olvera, A., Romero, C., Zamudio, F., & Alagon, A. (2020). Neotropical Rattlesnake (Crotalus simus) Venom Pharmacokinetics in Lymph and Blood Using an Ovine Model. Toxins, 12(7), 455. doi:10.3390/toxins12070455
376. Mourao, C. B. F., Brand, G. D., Fernandes, J. P. C., Prates, M. V., Bloch, C., Jr., Barbosa, J., Freitas, S. M., Restano-Cassulini, R., Possani, L. D., & Schwartz, E. F. (2020). Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides. Journal of Medicinal Chemistry, 63(17), 9500-9511. doi:10.1021/acs.jmedchem.0c00686
377. Vargas-Jaimes, L., Rodriguez, M. C., Argotte-Ramos, R., Juárez-González, V. R., Pastor, N., Cesa-Luna, C., Possani, L. D., & Quintero-Hernández, V. (2021). Recombinant C-Terminal Domains from Scorpine-like Peptides Inhibit the Plasmodium berghei Ookinete Development In Vitro. International Journal of Peptide Research and Therapeutics, 27(1), 817-829. doi:10.1007/s10989-020-10130-7
378. Rodriguez-Ravelo, R., Ruiz-Urquiola, A., Possani-Postay, L. D., Morris-Quevedo, H. J., Rodriguez-Ravelo, M., & Espinosa-Lopez, G. (2021). Variation of cytochrome oxidase-I gene and venom proteins of Rhopalurus junceus populations in the Moanicum sector: Pharmacological implications. Journal of Pharmacy & Pharmacognosy Research, 9(1), 1-12.
379. Lopes, K. S., Quintanilha, M. V. T., de Souza, A. C. B., Zamudio-Zuniga, F., Possani, L. D., & Mortari, M. R. (2021). Antiseizure potential of peptides from the venom of social wasp Chartergellus communis against chemically-induced seizures. Toxicon, 194, 23-36. doi:10.1016/j.toxicon.2021.02.009
380. Jimenez-Vargas, J. M., Ramirez-Carreto, S., Corzo, G., Possani, L. D., Becerril, B., & Ortiz, E. (2021). Structural and functional characterization of NDBP-4 family antimicrobial peptides from the scorpion Mesomexovis variegatus. Peptides, 141, 170553. doi:10.1016/j.peptides.2021.170553
381. Alamilla, J., Jimenez-Vargas, J. M., Galvan-Hernandez, A. R., Reyes-Mendez, M. E., Bermudez-Guzman, M. J., Restano-Cassulini, R., Olamendi-Portugal, T., Zamudio, F. Z., Possani, L. D., & Valdez-Velazquez, L. L. (2021). Toxin Ct1a, from venom of Centruroides tecomanus, modifies the spontaneous firing frequency of neurons in the suprachiasmatic nucleus. Toxicon, 197, 114-125. doi:10.1016/j.toxicon.2021.04.015
382. Beltran-Vidal, J., Carcamo-Noriega, E., Pastor, N., Zamudio-Zuniga, F., Guerrero-Vargas, J. A., Castano, S., Possani, L. D., & Restano-Cassulini, R. (2021). Colombian Scorpion Centruroides margaritatus: Purification and Characterization of a Gamma Potassium Toxin with Full-Block Activity on the hERG1 Channel. Toxins, 13(6), 407. doi:10.3390/toxins13060407
383. Riano-Umbarila, L., Romero-Moreno, J. A., Ledezma-Candanoza, L. M., Olamendi-Portugal, T., Possani, L. D., & Becerril, B. (2021). Full Neutralization of Centruroides sculpturatus Scorpion Venom by Combining Two Human Antibody Fragments. Toxins, 13(10), 708. doi:10.3390/toxins13100708
384. Salazar, M. H., Clement, H., Corrales-Garcia, L. L., Sanchez, J., Cleghorn, J., Zamudio, F., Possani, L. D., Acosta, H., & Corzo, G. (2022). Heterologous expression of four recombinant toxins from Panamanian scorpions of the genus Tityus and Centruroides for production of antivenom. Toxicon X, 13, 100090. doi:10.1016/j.toxcx.2021.100090
385. Bermudez-Guzman, M. J., Jimenez-Vargas, J. M., Possani, L. D., Zamudio, F., Orozco-Gutierrez, G., Oceguera-Contreras, E., Enriquez-Vara, J. N., Vazquez-Vuelvas, O. F., Garcia-Villalvazo, P. E., & Valdez-Velazquez, L. L. (2022). Biochemical characterization and insecticidal activity of isolated peptides from the venom of the scorpion Centruroides tecomanus. Toxicon, 206, 90-102. doi:10.1016/j.toxicon.2021.12.015
386. Csoti,A., Nájera-Meza, R.C., Bogár, F., Tajti, G., Szanto, R.G., Varga, Z., Gurrola, B.G., Tóth,G.K., Possani, L.D., Panyi, G. (2022). sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity. Biochemical Pharmacology 199:115023.
387. Delgado-Prudencio, G., Cid-Uribe J.I., Morales, A.J., Possani, L.D., Ortiz, E., Romero-Gutiérrez, T. (2022). The enzymatic core of Scorpion venoms. Toxins, 14 (4), 248
Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx
UNAM Posgrado