Contacto
Campos de conocimiento
Biofísica
Bioquímica
Reconocimiento Molecular y Bioestructura
Líneas de investigación
Bases biofísico-estructurales del reconocimiento proteínas alergénicas-anticuerpo y receptor-anticuerpo.
Caracterización bioquímico-estructural de proteínas y enzimas que unen e hidrolizan carbohidratos.
Cristalografía de proteínas y complejos proteína-proteína, proteína-ligando.
Publicaciones
- Sarmiento-Pavía PD, Rodríguez-Hernández A, Rodríguez-Romero A, Sosa-Torres ME. The structure of a novel membrane-associated 6-phosphogluconate dehydrogenase from Gluconacetobacter diazotrophicus (Gd6PGD) reveals a subfamily of short-chain 6PGDs. FEBS J. 2020 Jul 4. doi: 10.1111/febs.15472. F.I. 4.1
- Mares-Mejía I, García-Ramírez B, Torres-Larios A, Rodríguez-Hernández A, Osornio-Hernández AI, Terán-Olvera G, Ortega E, Rodríguez-Romero A. Novel murine mAbs define specific and cross-reactive epitopes on the latex profilin panallergen Hev b 8. Mol Immunol. 2020 Dec;128:10-21. doi: 10.1016/j.molimm.2020.09.017. F.I. 4.4
- Energetic and structural effects of the Tanford transition on ligand recognition of bovine β-lactoglobulin. Labra-Núñez A., Cofas-Vargas, L.F. Gutiérrez-Magdaleno, G., Gómez-Velasco, H., Rodríguez-Hernández, A., Rodríguez-Romero A., García-Henrnández E. Arch. Biochem. Biophys., 699, 108750 January 2021. doi.org/10.1016/j.abb.2020.108750. F.I 4.01
- Romero-Romero, S.; Costas, M; Silva D. A.; Kordes, S.; Rojas-Ortega, E.; Tapia, C.; Guerra, Y.; Shanmugaratnam, S.; Rodríguez-Romero, A.; Baker, D; Hocker, B.; Fernandez-Velasco, D. A. The stability landscape of de novo TIM barrels explored by a modular design approach. Journal of Molecular Biology 433,167153, 2021, doi.org/10.1016/j.jmb.2021.167153. F.I 5.47
- Ramírez-Silva L, Hernández-Alcántara G, Guerrero-Mendiola C, González-Andrade M, Rodríguez-Romero A, Rodríguez-Hernández A, Lugo-Munguía A, Gómez-Coronado PA, Rodríguez-Méndez C, Vega-Segura A. The K+-Dependent and -Independent Pyruvate Kinases Acquire the Active Conformation by Different Mechanisms. Int J Mol Sci. 2022 Jan 25;23(3):1347. doi: 10.3390/ijms23031347. F.I. 6.2
- García-Ramírez B, Mares-Mejía I, Rodríguez-Hernández A, Cano-Sánchez P, Torres-Larios A, Ortega E, Rodríguez-Romero A. A native IgE in complex with profilin provides insights into allergen recognition and cross-reactivity. Commun Biol. 2022 Jul 27;5(1):748. doi: 10.1038/s42003-022-03718-w. F.I. 5.49
- Toiber-Estrella AL, Quintero-Martínez A, Rodríguez-Romero A, Riveros-Rosas H, Hernández-Santoyo A. Structural and evolutionary insights into the multidomain galectin from the red abalone Haliotis rufescens with specificity for sulfated glycans. Fish Shellfish Immunol. 2022 Dec;131:1264-1274. doi: 10.1016/j.fsi.2022.11.015. F.I 4.59
-Terán MG, García-Ramírez B, Mares-Mejía I, Ortega E, O'Malley A, Chruszcz M, Rodríguez-
Romero A. Molecular Basis of Plant Profilins' Cross-Reactivity. Biomolecules. 2023 Mar
28;13(4):608. doi: 10.3390/biom13040608.
-Marcos-Viquez J, Rodríguez-Hernández A, Álvarez-Añorve LI, Medina-García A, Plumbridge J,
Calcagno ML, Rodríguez-Romero A, Bustos-Jaimes I. Substrate binding in the allosteric site
mimics homotropic cooperativity in the SIS-fold glucosamine-6-phosphate deaminases.
Protein Sci. 2023 Jun;32(6):e4651. doi: 10.1002/pro.4651.
-Pérez-Niño JA, Guerra Y, Díaz-Salazar AJ, Costas M, Rodríguez-Romero A, Fernández-Velasco DA. Stable monomers in the ancestral sequence reconstruction of the last opisthokont common ancestor of dimeric triosephosphate isomerase. Protein Sci. 2024 Sep;33(9):e5134. doi: 10.1002/pro.5134.
-Hernández-Benítez LJ, Ramírez-Rodríguez MA, Hernández-Santoyo A, Rodríguez-Romero A. A trimeric glycosylated GH45 cellulase from the red abalone (Haliotis rufescens) exhibits endo and exoactivity. PLoS One. 2024 Apr 18;19(4):e0301604. doi: 10.1371/journal.pone.0301604.
