Contacto
Campos de conocimiento
Bioinformática
Bioquímica
Microbiología Molecular
Reconocimiento Molecular y Bioestructura
Líneas de investigación
Evolución y manipulación de la relación estructura-función de proteínas. Ingeniería de Proteínas y Bioinformática
Bioprospección del metabolismo secundario en metagenomas marinos.
Publicaciones
1. Vazquez-Hernandez C., Loza A., Peguero-Sanchez E., Segovia L., and Gutierrez-Rios RM. (2018). Identification of reaction organization patterns that naturally cluster enzymatic transformations. BMC Systems Biology Accepted.
2. García-Guevara F., Bravo I., Martínez-Anaya C., and Segovia L. (2017). Cofactor specificity switch in Shikimate dehydrogenase by rational design and consensus engineering. Protein Eng Des Sel 1-9 DOI: 10.1093/protein/gzx031
3. García-Guevara F., Avelar M., Ayala M., and Segovia L. (2016). Computational Tools Applied to Enzyme design- a review. Biocatalysis. 1:1. DOI: 10.1515/boca-2015-0009.
4. Bedoya-Lopez,A., Estrada,K., Sanchez-Flores,A., Ramirez,O.T., Altamirano,C., Segovia,L. ,Miranda-Rios,J., Trujillo-Roldan,M.A., and Valdez-Cruz,N.A. (2016). Effect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human Tissue Plasminogen Activator Production Culture PLoS ONE, 11, e0151529.
5. Ayala M., Segovia L., and Torres E. (2016). Halogenases: A Biotechnological Alternative for the Synthesis of Halogenated Pharmaceuticals. Mini-Reviews in Medicinal Chemistry.16(14):1100-11.
6.Pastor N., Dávila S., Pérez-Rueda E., Segovia L., and Martínez-Anaya
C. (2015) Electrostatic analysis of bacterial expansins. PROTEINS: Structure, Function, and Bioinformatics. 83:215-223
7. Armenta-Medina D., Segovia L., and Perez-Rueda E. (2014) Comparative genomics of nucleotide metabolism: a tour to the past of the three cellular domains of life. BMC Genomics 15:800
8. Olarte-Lozano M., Mendoza-Nuñez M.A., Pastor N., Segovia L., Folch- Mallol J., and Martinez-Anaya C. (2014) PcExl1 a Novel Acid Expansin- Like Protein from the Plant Pathogen Pectobacterium carotovorum, Binds Cell Walls Differently to BsEXLX1. PLoS ONE 9:e95638
9. Peimbert M., Alcaraz LD., Bonilla-Rosso G., Olmedo-Alvarez G., García-Oliva F., Segovia L., Eguiarte L.E., and Souza V. (2012) Comparative metagenomics of two microbial mats at Cuatro Ciénegas Basin I: Ancient lessons on how to cope with an environment under severe nutrient stress. Astrobiology -12,648-658.
10. Rivera-Gomez N., Segovia L., and Perez-Rueda E., (2011) The diversity and distribution of TFs and their partner domains play an important role in the regulatory plasticity in bacteria. Microbiology, 157, 2308-2318.
11. Quiroz-Castañeda R.E., Martínez-Anaya C., Cuervo-Soto L.I., Segovia L., and Folch-Mallol J.L. (2011) Loosenin, a novel protein with cellulose- disrupting activity from Bjerkandera adusta. Microbial Cell Factories , 10, 8
