Aplicaciones del DNA sintético. Ingeniería de Proteínas por evolución dirigida. Genómica de poblaciones humanas, farmacogenómica. Microbioma humano infeccioso.

Publicaciones

Ayon-Nunez,D.A. Fragoso,G. Espitia,C. Garcia-Varela,M. Soberon,X. Rosas,G. Laclette,J.P. Bobes,R.J. 2018. Identification and characterization of Taenia solium enolase as a plasminogen-binding protein Acta Tropica, 182, 69-79.

Gonzalez-Covarrubias,V. Urena-Carrion,J. Villegas-Torres,B. Cossio-Aranda,J.E. Trevethan-Cravioto,S. Izaguirre-Avila,R. Fiscal-Lopez,O.J. Soberon,X. 2017. Pharmacogenetic Variation in Over 100 Genes in Patients Receiving Acenocumarol Frontiers in Pharmacology, 8, 863

Bikel,S. Jacobo-Albavera,L. Sanchez-Munoz,F. Cornejo-Granados,F. Canizales-Quinteros,S. Soberon,X. Sotelo-Mundo,R.R. Del Rio-Navarro,B.E. Mendoza-Vargas,A. Sanchez,F. Ochoa-Leyva,A. 2017. A novel approach for human whole transcriptome analysis based on absolute gene expression of microarray data PeerJ., 5, e4133.

Romero-Hidalgo,S. Ochoa-Leyva,A. Garciarrubio,A. Acuna-Alonzo,V. Antunez-Arguelles,E. Balcazar-Quintero,M. Barquera-Lozano,R. Carnevale,A. Cornejo-Granados,F. Fernandez-Lopez,J.C. Garcia-Herrera,R. Garcia-Ortiz,H. Granados-Silvestre,A. Granados,J. Guerrero-Romero,F. Hernandez-Lemus,E. Leon-Mimila,P. Macin-Perez,G. Martinez-Hernandez,A. Menjivar,M. Morett,E. Orozco,L. Ortiz-Lopez,G. Perez-Villatoro,F. Rivera-Morales,J. Riveros-McKay,F. Villalobos-Comparan,M. Villamil-Ramirez,H. Villarreal-Molina,T. Canizales-Quinteros,S. Soberon,X. 2017. Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing Nature Communications, 8, 1005.

Navarrete-Perea,J. Isasa,M. Paulo,J.A. Corral-Corral,R. Flores-Bautista,J. Hernandez-Tellez,B. Bobes,R.J. Fragoso,G. Sciutto,E. Soberon,X. Gygi,S.P. Laclette,J.P. 2017. Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs PLoS Neglected Tropical Diseases, 11, e0005962.

Bobes,R.J. Navarrete-Perea,J. Ochoa-Leyva,A. Anaya,V.H. Hernandez,M. Cervantes-Torres,J. Estrada,K. Sanchez-Lopez,F. Soberon,X. Rosas,G. Maroni-Nunes C. Garcia-Varela,M. Sotelo-Mundo,R.R. Lopez-Zavala,A.A. Gevorkian,G. Acero,G. Laclette,J.P. Fragoso,G. Sciutto,E. 2017. Experimental and theoretical approaches to investigate the immunogenicity of Taenia solium-derived KE7 antigen Infection and Immunity, 85, e00395-17.

Mercader,J.M. Liao,R.G. Davis,A. Dymek,Z. Estrada,K. Tukiainen,T. Huerta-Chagoya,A. Moreno-Macias,H. Jablonski,K.A. Hanson,R.L. Walford,G.A. Moran,I. Chen,L. Agarwala,V. Ordonez-Sanchez,M.L. Rodriguez-Guillen,R. Rodriguez-Torres,M. Segura-Kato,Y. Garcia-Ortiz,H. Centeno-Cruz,F. Barajas-Olmos,F. Caulkins,L. Puppala,S. Fontanillas,P. Williams,A. Bonas-Guarch,S. Hartl,C. Ripke,S. Tooley,K. Lane,J. Zerrweck,C. Martinez-Hernandez,A. Cordova,E.J. Mendoza-Caamal,E. Contreras-Cubas,C. Gonzalez-Villalpando,M.E. Cruz-Bautista,I. Munoz-Hernandez,L. Gomez-Velasco,D. Alvirde,U. Henderson,B.E. Wilkens,L.R. Le,M.L. Arellano-Campos,O. Riba,L. Harden,M. Platform,B.G. Gabriel,S. Abboud,H.E. Cortes,M.L. Revilla-Monsalve,C. Islas-Andrade,S. Soberon,X. Curran,J.E. Jenkinson,C.P. Defronzo,R.A. Lehman,D.M. Hanis,C.L. Bell,G.I. Boehnke,M. Blangero,J. Duggirala,R. Saxena,R. MacArthur,D. Ferrer,J. McCarroll,S.A. Torrents,D. Knowler,W.C. Baier,L.J. Burtt,N. Gonzalez-Villalpando,C. Haiman,C.A. Aguilar-Salinas,C.A. Tusie-Luna,T. Flannick,J. Jacobs,S.B.R. Orozco,L. Altshuler,D. Florez,J.C. 2017. A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes Diabetes, 66, 2903-2914

Cruz-Correa,O.F. Leon-Cachon,R.B. Barrera-Saldana,H.A. Soberon,X. 2017. Prediction of atorvastatin plasmatic concentrations in healthy volunteers using integrated pharmacogenetics sequencing Pharmacogenomics, 18, 121-131.

Navarrete-Perea,J. Moguel,B.A. Bobes,R.J. Villalobos,N. Carrero,J.C. Sciutto,E. Soberon,X. Laclette,J.P. 2017. Protein profiles of Taenia solium cysts obtained from skeletal muscles and the central nervous system of pigs: Search for tissue-specific proteins Experimental Parasitology, 172, 23-29.

Gonzalez-Covarrubias,V. Martinez-Magana,J.J. Coronado-Sosa,R. Villegas-Torres,B. Genis-Mendoza,A.D. Canales-Herrerias,P. Nicolini,H. Soberon,X. 2016. Exploring Variation in Known Pharmacogenetic Variants and its Association with Drug Response in Different Mexican Populations Pharmaceutical Research, 33, 2644-2652

Navarrete-Perea,J. Toledano-Magana,Y. Torre,P. Sciutto,E. Bobes,R.J. Soberon,X. Laclette,J.P. 2016. Role of porcine serum haptoglobin in the host-parasite relationship of Taenia solium cysticercosis Molecular and Biochemical Parasitology, 207, 61-67.

Bikel,S. Valdez-Lara,A. Cornejo-Granados,F. Rico,K. Canizales-Quinteros,S. Soberon,X. Del Pozo-Yauner,L. Ochoa-Leyva,A. 2015. Combining metagenomics, metatranscriptomics and viromics to explore novel microbial interactions: towards a systems-level understanding of human microbiome Computational and Structural Biotechnology Journal, 13, 390-401.

Gomez,S. Adalid-Peralta,L. Palafox-Fonseca,H. Cantu-Robles,V.A. Soberon,X. Sciutto,E. Fragoso,G. Bobes,R.J. Laclette,J.P. Yauner,L.D. Ochoa-Leyva,A. 2015. Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR) Scientific Reports, 5, 9683 [erratum en vol 5 (12385) ]

Villegas-Torres,B. Sanchez-Giron,F. Jaramillo-Villafuerte,K. Soberon,X. Gonzalez-Covarrubias,V. 2015. Genotype frequencies of VKORC1 and CYP2C9 in Native and Mestizo populations from Mexico, potential impact for coumarin dosing Gene, 558, 235-240

Moreno-Estrada,A. Gignoux,C.R. Fernandez-Lopez,J.C. Zakharia,F. Sikora,M. Contreras,A.V. Acuna-Alonzo,V. Sandoval,K. Eng,C. Romero-Hidalgo,S. Ortiz-Tello,P. Robles,V. Kenny,E.E. Nuno-Arana,I. Barquera-Lozano,R. Macin-Perez,G. Granados-Arriola,J. Huntsman,S. Galanter,J.M. Via,M. Ford,J.G. Chapela,R. Rodriguez-Cintron,W. Rodriguez-Santana,J.R. Romieu,I. Sienra-Monge,J.J. del Rio-Navarro,B. London,S.J. Ruiz-Linares,A. Garcia-Herrera,R. Estrada,K. Hidalgo-Miranda,A. Jimenez-Sanchez,G. Carnevale,A. Soberon,X. Canizales-Quinteros,S. Rangel-Villalobos,H. Silva-Zolezzi,I. Burchard,E.G. Bustamante,C.D. 2014. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits Science, 344, 1280-1285

Estrada,K. Aukrust,I. Bjorkhaug,L. Burtt,N.P. Mercader,J.M. Garcia-Ortiz,H. Huerta-Chagoya,A. Moreno-Macias,H. Walford,G. Flannick,J. Williams,A.L. Gomez-Vazquez,M.J. Fernandez-Lopez,J.C. Martinez-Hernandez,A. Centeno-Cruz,F. Mendoza-Caamal,E. Revilla-Monsalve,C. Islas-Andrade,S. Cordova,E.J. Soberon,X. Gonzalez-Villalpando,M.E. Henderson,E. Wilkens,L.R. Le Marchand,L. Arellano-Campos,O. Ordonez-Sanchez,M.L. Rodriguez-Torres,M. Rodriguez-Guillen,R. Riba,L. Najmi,L.A. Jacobs,S.B. Fennell,T. Gabriel,S. Fontanillas,P. Hanis,C.L. Lehman,D.M. Jenkinson,C.P. Abboud,H.E. Bell,G.I. Cortes,M.L. Boehnke,M. Gonzalez-Villalpando,C. Orozco,L. Haiman,C.A. Tusie-Luna,T. Aguilar-Salinas,C.A. Altshuler,D. Njolstad,P.R. Florez,J.C. Macarthur,D.G. 2014. Association of a Low-Frequency Variant in HNF1A With Type 2 Diabetes in a Latino Population JAMA, 311, 2305-2314

Williams,A.L. Jacobs,S.B. Moreno-Macias,H. Huerta-Chagoya,A. Churchhouse,C. Marquez-Luna,C. Garcia-Ortiz,H. Gomez-Vazquez,M.J. Burtt,N.P. Aguilar-Salinas,C.A. Gonzalez-Villalpando,C. Florez,J.C. Orozco,L. Haiman,C.A. Tusie-Luna,T. Altshuler,D. Williams,A.L. Marquez-Luna,C. Huerta-Chagoya,A. Ripke,S. Gomez-Vazquez,M.J. Manning,A.K. Moreno-Macias,H. Garcia-Ortiz,H. Neale,B. Burtt,N.P. Aguilar-Salinas,C.A. Reich,D. Stram,D.O. Fernandez-Lopez,J.C. Romero-Hidalgo,S. Altshuler,D. Florez,J.C. Tusie-Luna,T. Patterson,N. Haiman,C.A. Aguilar-Delfin,I. Martinez-Hernandez,A. Centeno-Cruz,F. Mendoza-Caamal,E. Revilla-Monsalve,C. Islas-Andrade,S. Cordova,E. Rodriguez-Arellano,E. Soberon,X. Orozco,L. Florez,J.C. Gonzalez-Villalpando,C. Gonzalez-Villalpando,M.E. Haiman,C.A. Henderson,B.E. Monroe,K. Wilkens,L. Kolonel,L.N. Le Marchand,L. Riba,L. Ordonez-Sanchez,M.L. Rodriguez-Guillen,R. Cruz-Bautista,I. Rodriguez-Torres,M. Munoz-Hernandez,L.L. Saenz,T. Gomez,D. Alvirde,U. Burtt,N.P. Onofrio,R.C. Brodeur,W.M. Gage,D. Murphy,J. Franklin,J. Mahan,S. Ardlie,K. Crenshaw,A.T. Winckler,W. Prufer,K. Shunkov,M.V. Sawyer,S. Stenzel,U. Kelso,J. Lek,M. Sankararaman,S. Williams,A.L. Patterson,N. Macarthur,D.G. Reich,D. Derevianko,A.P. Paabo,S. Jacobs,S.B. Churchhouse,C. Gopal,S. Grammatikos,J.A. Smith,I.C. Bullock,K.H. Deik,A.A. Souza,A.L. Pierce,K.A. Clish,C.B. Altshuler,D. Fennell,T. Farjoun,Y. Genomics,P.B. Gabriel,S. Stram,D.O. Gross,M.D. Pereira,M.A. Seielstad,M. Koh,W.P. Tai,E.S. Flannick,J. Fontanillas,P. Morris,A. Teslovich,T.M. Burtt,N.P. Atzmon,G. Blangero,J. Bowden,D.W. Chambers,J. Shin,C.Y. Duggirala,R. Glaser,B. Hanis,C. Kooner,J. Laakso,M. Lee,J.Y. Tai,E.S. Ying,T.Y. Wilson,J.G. Haiman,C.A. Henderson,B.E. Monroe,K. Wilkens,L. Kolonel,L.N. Le Marchand,L. Puppala,S. Farook,V.S. Thameem,F. Abboud,H.E. Defronzo,R.A. Jenkinson,C.P. Lehman,D.M. Curran,J.E. Blangero,J. Duggirala,R. Burtt,N.P. Cortes,M.L. Altshuler,D. Florez,J.C. Haiman,C.A. Henderson,B.E. Aguilar-Salinas,C.A. Gonzalez-Villalpando,C. Orozco,L. Tusie-Luna,T. 2014. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico Nature, 506, 97-101

Ochoa-Leyva,A. Montero-Moran,G. Saab-Rincon,G. Brieba,L.G. Soberon,X. 2013. Alternative Splice Variants in TIM Barrel Proteins from Human Genome Correlate with the Structural and Evolutionary Modularity of this Versatile Protein Fold PLoS ONE, 8, e70582.

Tsai,I.J. Zarowiecki,M. Holroyd,N. Garciarrubio,A. Sanchez-Flores,A. Brooks,K.L. Tracey,A. Bobes,R.J. Fragoso,G. Sciutto,E. Aslett,M. Beasley,H. Bennett,H.M. Cai,J. Camicia,F. Clark,R. Cucher,M. De Silva,N. Day,T.A. Deplazes,P. Estrada,K. Fernandez,C. Holland,P.W.H. Hou,J. Hu,S. Huckvale,T. Hung,S.S. Kamenetzky,L. Keane,J.A. Kiss,F. Koziol,U. Lambert,O. Liu,K. Luo,X. Luo,Y. Macchiaroli,N. Nichol,S. Paps,J. Parkinson,J. Pouchkina-Stantcheva,N. Riddiford,N. Rosenzvit,M. Salinas,G. Wasmuth,J.D. Zamanian,M. Zheng,Y. Cai,X. Soberon,X. Olson,P.D. Laclette,J.P. Brehm,K. Berriman,M. Ochoa-Leyva,A. 2013. The genomes of four tapeworm species reveal adaptations to parasitism Nature, 496, 57-63.

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx