1) Papel de las inhibinas y el betaglicano en la regulación del sistema inmune
2) Papel de CD5 en la regulación de la diferenciación y activación de los linfocitos T.
3) Generación de células T reguladoras alospecíficas con potencial terapéutico en trasplante renal.
4) Papel de los exosomas tumorales y los adiposomas en la regulación del microambiente inflamatorio en cancer de mama en obesidad.
5) Papel de los exosomas tumorales en la regulación del microambiente tumoral en cáncer de colon

Publicaciones

1. Antonio-Herrera L, Badillo-Godinez O, Medina-Contreras O, Tepale-Segura A, García-Lozano A, Gutierrez-Xicotencatl L, Soldevila G, Esquivel-Guadarrama FR, Idoyaga J, Bonifaz LC. The Nontoxic Cholera B Subunit Is a Potent Adjuvant for Intradermal DC-Targeted Vaccination.Front Immunol. 2018 Sep 27;9:2212. F. I.6.
2. de la Fuente-Granada M, Olguin-Alor R, Ortega-Francisco S, Bonifaz LC and Soldevila G1. , Inhibins regulate peripheral regulatory T cell induction through modulation of dendritic cell function. FEBS Open Bio. 2018 Dec 11;9(1):137-147. Soldevila corresponding autor. F.I:2.1
3. Burgueno-Bucio E, Mier-Aguilar C and Soldevila G. The multiple faces of CD5. J Leuk Biol. 2019 Jan 24. doi: 10.1002/JLB.MR0618-226R G. Soldevila corresponding author.FI: 4.289
4. Martínez-Cortés I, Acevedo-Domínguez NA, Olguin-Alor R, Cortés-Hernández A, Álvarez-Jiménez V, Campillo-Navarro M, Sumano-López HS, Gutiérrez-Olvera L, Martínez-Gómez D, Maravillas-Montero JL, Loor JJ, García-Zepeda EA, Soldevila G. Tilmicosin modulates the innate immune response and preserves casein production in bovine mammary alveolar cells during Staphylococcus aureus infection. J Anim Sci. 2019 Feb 1;97(2):644-656 Soldevila corresponding autor. F.I:1.714
5. Saint-Martin A, Martínez-Ríos J, Castañeda-Patlán MC, Sarabia-Sánchez MA, Tejeda-Muñoz N, Chinney-Herrera A, Soldevila G, Benelli R, Santoyo-Ramos P, Poggi A, Robles-Flores M. Functional Interaction of Hypoxia-Inducible Factor 2-Alpha and Autophagy Mediates Drug Resistance in Colon Cancer Cells. Cancers (Basel). 2019 May 30;11(6). pii: E755. doi: 10.3390/cancers11060755.
6. Li H, Burgueño-Bucio E, Xu S, Das S, Olguin-Alor R, Elmets CA, Athar M, Raman C, Soldevila G, Xu H. CD5 on dendritic cells regulates CD4+ and CD8+ T cell activation and induction of immune responses. PLoS One. 2019 Sep 6;14(9):e0222301. doi: 10.1371/journal.pone.0222301.
7. Large Scale Generation of Human allospecific induced T regs with functional stability of use in immunotherapy in Transplantation. Evelyn K Alvarez-Salazar, Cortes Hernandez, Arteaga Cruz, Alberu-Gomez and Soldevila G. Front. Immunol., 02 April 2020 | https://doi.org/10.3389/fimmu.2020.00375. G. Soldevila corresponding author
8. Ex vivo expansion of regulatory T cells from long-term Belatacept-treated kidney transplant patients restores their phenotype and suppressive function but not their FOXP3 TSDR demethylation status. Cortés-Hernández A, Alvarez-Salazar E, Arteaga-Cruz S, Alberu-Gómez J, Soldevila G. Cell Immunol. 2020 Feb;348:104044. doi: 10.1016/j.cellimm.2020.104044. Epub 2020 Jan 14. PMID: 32005344. G. Soldevila corresponding author.
9. Cortés-Hernández A, Alvarez-Salazar EK, Arteaga-Cruz S, Rosas-Cortina K, Linares N, Alberú Gómez JM, Soldevila G. Highly Purified Alloantigen-Specific Tregs From Healthy and Chronic Kidney Disease Patients Can Be Long-Term Expanded, Maintaining a Suppressive Phenotype and Function in the Presence of Inflammatory Cytokines. Front Immunol. 2021 Oct 28;12:686530. doi: 10.3389/fimmu.2021.686530. eCollection 2021.PMID: 34777330. G. Soldevila corresponding author
10. Aleida Nuñez-Ruiz, Flor Sánchez-Brena, Cynthia López-Pacheco, Naray Acevedo-Domínguez and Gloria Soldevila. Obesity modulates the immune macroenvironment associated with breast cancer development. PLoS One. 2022 Apr 26;17(4):e0266827. doi: 10.1371/journal.pone.0266827. eCollection 2022.PMID: 35472214. G. Soldevila corresponding author.
11. Cárdenas G, Chávez-Canales M, Espinosa AM, et al. Intranasal dexamethasone: a new clinical trial for the control of inflammation and neuroinflammation in COVID-19 patients. Trials. 2022 Feb 14;23(1):148. doi: 10.1186/s13063-022-06075-5.
12. Tereso J Guzmán, Martina Düfer, Mats Wiedemann, Roxana Olguín-Alor, Gloria Soldevila, Carmen M Gurrola-Díaz. Lupin γ-conglutin protects against cell death induced by oxidative stress and lipotoxicity, but transiently inhibits in vitro insulin secretion by increasing K ATP channel currents. International Journal of Biological Macromolecules. 2021 https://doi.org/10.1016/j.ijbiomac.2021.07.088
13. Jacquelynne Cervantes-Torres, Sergio Rosales-Mendoza, Carlos Cabello, Laura Montero et al. Towards the development of an epitope-focused vaccine for SARS-CoV 2. Vaccine (2022) https://doi.org/10.1016/j.vaccine.2022.09.059.
14. Duesman SJ, Ortega-Francisco S, Olguin-Alor R, Acevedo-Dominguez NA, Sestero CM, Chellappan R, De Sarno P, Yusuf N, Salgado-Lopez A, Segundo-Liberato M, de Oca-Lagunas SM, Raman C, Soldevila G Transforming growth factor receptor III (Betaglycan) regulates the generation of pathogenic Th17 cells in EAE.. Front Immunol. 2023 Feb 6;14:1088039. doi: 10.3389/fimmu.2023.1088039. eCollection 2023.PMID: 36855628
15. Sau l Arteaga-Cruz, Arimelek Cortes-Hernandez, Evelyn Katy Alvarez-Salazar, Katya Rosas-Cortina , Christian Aguilera-Sandoval , Luis E. Morales-Buenrostro , Josefina M. Alberú-Gómez and Gloria Soldevila. Highly purified and functionally stable in vitro expanded allospecific Tr1 cells expressing immunosuppressive graft-homing receptors as new candidates for cell therapy in solid organ transplantation. Front. Immunol. 14:1062456. doi: 10.3389/fimmu.2023.1062456

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx