Estudios bioquímicos, moleculares y omicos, sobre la regulación de la síntesis de proteínas recombinantes terapéuticas, producidas en sistemas procariotas o eucariotas.
Diseño, desarrollo y producción de nanoparticulas bioactivas para el tratamiento de contaminantes.

Publicaciones

1. Reynoso-Cereceda GI, Valdez-Cruz NA, Pérez NO, Trujillo-Roldán MA * (2024) A comprehensive study of glucose and oxygen gradients in a scaled-down model of recombinant HuGM-CSF production in thermoinduced Escherichia coli fed-batch cultures. Preparative Biochemistry & Biotechnology. https://doi.org/10.1080/10826068.2024.2347403 [IF 2.0]. Q3
2. Muñoz-Echeverri LM, Benavides-López S, Geiger O, Trujillo-Roldán MA, Valdez-Cruz NA* (2024) Bacterial extracellular vesicles: biotechnological perspective for enhanced productivity. World Journal of Microbiology and Biotechnology. World J Microbiol Biotechnol 40, 174 (2024). https://doi.org/10.1007/s11274-024-03963-7 [IF 4.0]. Q2.
3. ⁠González-Hernández RA, Valdez-Cruz NA, Trujillo-Roldán MA *. (2024) Factors that influence the extraction methods of terpenes from natural sources. Chem. Pap. https://doi.org/10.1007/s11696-024-03339-z. [IF 2.1]. Q3.
4. ⁠Valdez‑Cruz NA *, Rosiles-Becerril D, Martínez-Olivares CE, García‑Hernández E, Cobos-Marín L, Garzón D, López-Salas FE, Zavala G, Luviano A, Olvera A, Alagón A, Ramírez OT, Trujillo‑Roldán MA*. Oral administration of a recombinant modified RBD antigen of SARS-CoV-2 as a possible immunostimulant for the care of COVID-19. Microbial cell factories (2024). 23, 41. https://doi.org/10.1186/s12934-024-02320-5. ISSN 1475-2859. [IF 4.3]. Q1
5. González‑Hernández RA, Valdez‑Cruz NA, Macías‑Rubalcava ML, Trujillo‑Roldán MA*. Overview of fungal terpene synthases and their regulation. World Journal of Microbiology and Biotechnology. (2023) https://doi.org/10.1007/s11274-023-03635-y. [IF 4.0]. Q2.
6. Avello V., Torres M., Vergara M., Berrios, J., Valdez-Cruz, NA, Acevedo, C, Maria Molina Sampayo, Alan J. Dickson, Claudia Altamirano (2022). Enhanced recombinant protein production in CHO cell continuous cultures under growth-inhibiting conditions is associated with an arrested cell cycle in G1/G0 phase. Plos one, 17(11), e0277620; 10.1371/journal.pone.0277620. I.F. 2.9 Q1
7. Restrepo-Pineda, S., Rosiles-Becerril, D., Vargas-Castillo, A. B., Ávila-Barrientos, L. P., Luviano, A., Sánchez-Puig, N., García-Hernández E, Pérez NO, Trujillo-Roldán M. A., Valdez-Cruz, N. A.* (2022). Induction temperature impacts the structure of recombinant HuGM-CSF inclusion bodies in thermoinducible E. coli. Electronic Journal of Biotechnology, 59, 94-106. https://doi.org/10.1016/j.ejbt.2022.08.004 IF 2.3 Q3
8. Serrano-Carreón L, Aranda-Ocampo S, Balderas-Ruíz KA, Juárez AM, Leyva E, Trujillo-Roldán MA, Valdez-Cruz NA, Galindo E, (2022) A case study of a profitable mid-tech greenhouse for the sustainable production of tomato, using a biofertilizer and a biofungicide. Electronic Journal of Biotechnology, 59, 13-24. 10.1016/j.ejbt.2022.06.003 IF 2.3. Q3
9. Restrepo-Pineda S, Sánchez-Puig N, Pérez NO, García-Hernández E, Valdez-Cruz NA, Trujillo-Roldán MA*. (2022) The pre-induction temperature affects recombinant HuGM-CSF aggregation in thermoinducible Escherichia coli. Applied Microbiology and Biotechnology. ISSN: 0175-7598 (print); 1432-0614 (web). 10.1007/s00253-022-11908-z [IF 3.9]. Q2
10. Avila-Barrientos LP, Cofas-Vargas LF, Agüero-Chapin G, Hernández-García E, Ruiz-Carmona S, Valdez-Cruz NA, Trujillo-Roldán MA, Weber J, Ruiz-Blanco YB, Barril X, Garcia-Hernandez E*. (2022) Computational design of inhibitors targeting the catalytic subunit of Escherichia coli FOF1-ATP synthase. Antibiotics. 10.3390/antibiotics11050557; [IF 4.3]. Online ISSN: 2079-6382. Q1
11. Pérez-Rodriguez, S., Reynoso-Cereceda, G. I., Valdez-Cruz, N. A., & Trujillo-Roldán, M. A. (2022). A comprehensive comparison of mixing and mass transfer in shake flasks and their relationship with MAb productivity of CHO cells. Bioprocess and Biosystems Engineering, 1-13. 5:1033–1045. 10.1007/s00449-022-02722-y IF 3.5. Q2
12. Valdez-Cruz NA, Orozco-Sánchez F, Rodríguez-Monroy M, Busto VD, Trujillo-Roldán MA *. Enseñanza de la operación en biorreactores y el escalamiento de bioprocesos: capacitación multidisciplinaria en un curso teórico-práctico. Revista Educación en Ingeniería. 2022. 17(33), pp. 79-85. ISSN 1900-8260. https://educacioneningenieria.org/index.php/edi/article/view/1153/1037. [2021 JCI: 0.04] Q4.
13. López-Taborda, J. D., Vargas-Zapata, A., Ramírez-Vargas, J. F., Valdez-Cruz, N. A., Trujillo-Roldán, M. A., & Orozco-Sanchez, F.* (2022). Development and characterization of an alternative control system to study separately oxygen and momentum transfer effects in stirred tank bioreactors. Revista Mexicana De Ingeniería Química, 21(1), Proc2607-Proc2607. 10.24275/rmiq/Proc2607. IF 1.06 Q3
14. Campos-López, A., Uribe-López, J. A., Cázares-Ordoñez, V., Garibay-Orijel, R., Valdez-Cruz, N. A., & Trujillo-Roldán, M. A.* (2022). Quercetin and 1-methyl-2-oxindole mimic root signaling that promotes spore germination and mycelial growth of Gigaspora margarita. Mycorrhiza, 32(2), 177-191.10.1007/s00572-022-01074-5 IF 3.3 Q1
15. Balderas-Ruíz KA, Gómez-Guerrero CI, Trujillo-Roldán MA, Valdez-Cruz NA, Aranda-Ocampo S, Juárez AM, Leyva E, Galindo E, Serrano-Carreón L*. Bacillus velezensis 83 increases productivity and quality of tomato (Solanum lycopersicum L.): pre and postharvest assessment. Current Research in Microbial Sciences, 2121. 2: 100076. https://doi.org/10.1016/j.crmicr.2021.100076. F.I 4.8 Q1.
16. García-Cabrera RI, Valdez-Cruz NA, Daniel-Vázquez A, Blancas-Cabrera A, Trujillo-Roldán MA* (2021). Roles of culture media and oxygen transfer in the scale-up from shake flasks to pneumatic bioreactor of the plant growth-promoting bacterium Rhizobium phaseoli. 2021. Revista Mexicana de Ingeniería Química, 20(2), 1093-1111. 10.24275/rmiq/Bio2297 I.F.: 1.063. Q4
17. Restrepo-Pineda S, Pérez NO, Valdez-Cruz NA, Trujillo-Roldán MA. Thermoinducible expression system for producing recombinant proteins in Escherichia coli: advances and insights. (2021). FEMS Microbiology Reviews, 10.1093/femsre/fuab023. I.F. 10.1 Online ISSN 1574-6976. Print ISSN 0168-6445 Q1
18. Valdez-Cruz NA*, García-Hernández E, Espitia C, Cobos-Marín L, Altamirano C, Bando-Campos CG, Cofas-Vargas LF, Coronado-Aceves EW, González-Hernández RA, Hernández-Peralta P, Juárez-López D, Ortega-Portilla PA, Restrepo-Pineda S, Zelada-Cordero P, Trujillo-Roldán MA*. Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatment. (2021). Microbial Cell Factories. I.F. 4.3. Q1
19. Pérez-Rodriguez S, Wulff T, Gunnar Voldbor B, Altamirano C, Trujillo-Roldán MA, Valdez-Cruz NA*. Compartmentalized proteomic profiling outlines the crucial role of the Classical Secretory Pathway during recombinant protein production in Chinese hamster ovary cells. ACS Omega (2021). 10.1021/acsomega.0c06030. I.F. 3.7. ISSN: 2470-1343 (print); 2470-1343 (web). Q2
20. Pérez-Rodriguez S, Ramírez-Lira MJ, Wulff T, Gunnar Voldbor B, Ramírez OT, Trujillo-Roldán MA, Valdez-Cruz NA* (2020) Enrichment of microsomes from Chinese hamster ovary cells by subcellular fractionation for its use in proteomic analysis. PLoS ONE 15(8): e0237930. 10.1371/journal.pone.0237930 . I.F. 2.9 Q1
21. Pérez-Rodriguez S, Ramírez OT, Trujillo-Roldán MA, Valdez-Cruz NA*. Comparison of protein precipitation methods for sample preparation prior to proteomic analysis of Chinese hamster ovary cell homogenates. Electronic Journal of Biotechnology. (2020) 10.1016/j.ejbt.2020.09.006. I.F.: 2.3 Q3
22. García-Cabrera RI, Valdez-Cruz NA, Blancas-Cabrera A, Trujillo-Roldán MA. Oxygen transfer affect polyhydroxybutyrate production and oxidative stress response in submerged cultures of Rhizobium phaseoli. Biochemical Engineering Journal. (2020) 162:107721. doi: 10.1016/j.bej.2020.107721 I.F. 3.7 Q2
23. Pérez-Rodriguez S, Ramírez-Lira MJ, Trujillo-Roldán MA, Valdez-Cruz NA*. Nutrient supplementation stimulates culture longevity, monoclonal antibody production and oxidative metabolism of Chinese hamster ovary cells. Bioengineered (2020) 11(1):463-471. 10.1080/21655979.2020.1744266. I.F. 4.2 Print ISSN: 2165-5979 Online ISSN: 2165-5987. I.F. 4.9. Q1
24. Ángeles-Argáiz, R. E., Carmona-Reyes, I. A., Quintero-Corrales, C. A., Medina-Macías, F. J., Blancas-Cabrera, A., Valdez-Cruz, N. A., ... & Garibay-Orijel, R. (2020). From field sampling to pneumatic bioreactor mycelia production of the ectomycorrhizal mushroom Laccaria trichodermophora. Fungal biology, 124(3-4), 205-218. 10.1016/j.funbio.2020.02.003 . IF. 2.91 Q2

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx