Se centra en la inmunología y la biología del cáncer, estudiando los mecanismos moleculares a través de los cuales la sialomucina CD43 regula las funciones de los leucocitos y contribuye a la transformación de las células tumorales. Además, identificar y caracterizar péptidos de defensa del huésped con funciones inmunorreguladoras. Su investigación ha proporcionado información valiosa para la inmunoterapia y la biología del cáncer.

Publicaciones

81. José Ignacio Veytia-Bucheli JI, Jiménez-Vargas JM, Melchy-Pérez E, Sandoval-Hernández MA, Possani LD, & Rosenstein Y. Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation. Cell Communication and Signaling 2018; 16: 45. doi: 10.1186/s12964-018-0257-7, 2018 ISSN: 1478-811X

82. Cardon S, Sachon E, Carlier E, Drujon T, Walrant A, Aleman-Navarro E, Martinez-Osorio V, Guianvarc’h D, Sagan S, Fleury Y, Marquant R, Piesse C, Rosenstein Y, Auvynet C, Lacombe C: Peptidoglycan potentiates the membrane disrupting effect of the carboxyamidated form of DMS-DA6, a Gram-positive selective antimicrobial peptide isolated from Pachymedusa dacnicolor skin. PLoS ONE 13(10): e0205727. https://doi.org/ 10.1371/journal.pone.0205727, 2018. ISSN: 1932-6203

83. Uriostegui-Arcos M, Aguayo- Ortiz R, Valencia-Morales M del P, Melchy- Pérez E, Rosenstein Y, Dominguez L, Zurita M. 2020 Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer. Open Biol. 10:200050. http://dx.doi.org/10.1098/rsob.200050

84. Pérez-Morales D, Nava-Galeana J, Rosales-Reyes R, Teehan P, Yakhnin H,. Melchy-Pérez E, Rosenstein Y,. De la Cruz MA, Babitzke P & Bustamante VH: An incoherent feedforward loop formed by SirA/BarA, HilE and HilD is involved in controlling the growth cost of virulence factor expression by S. Typhimurium. PLOS Pathogens 2021 28;17(5):e1009630 doi: 10.1371/journal.ppat.1009630.

85. Vega-Mendoza D, Alicia Cañas-Linares A, Flores-Alcantar A, Espinosa-Neira R, Melchy-Perez E, Vera-Estrella R, Auvynet C & Rosenstein Y: CD43 (sialophorin) is involved in the induction of extracellular matrix remodeling and angiogenesis by lung cancer cells” J. Cellular Physiology 236(9):6643-6656, 2021. doi: 10.1002/jcp.30308

86. Ramírez-González A, Manzo-Merino J, Contreras-Ochoa CO, Bahena-Román M, Manasés Aguilar-Villaseñor J, Lagunas-Martínez A, Rosenstein Y, Madrid Marina V & Torres-Poveda K. Functional role of AKNA: A scoping review. Biomolecules (MDPI) 2021, 11(11), 1709; https://doi.org/10.3390/biom11111709

87. Lozano JJ, Mendoza E, Pérez López A, Rosenstein Y & Prieto A: Secuelas: el síndrome post-COVID. ¿ Cómoves? Revista de Divulgación de la Ciencia-UNAM, n0 275, pags 1-6, Octubre 2021 (portada)

88. Diethelm-Varela B, Reyes A, Rosenstein Y, Kalil J, Hill M, Docena G, Anegon I, González PA, Kalergis AM. Federation of Clinical Immunology Societies Goes South 2021: advanced course on molecular and cellular translational immunology. Immunotherapy. 2022 Aug;14(11):839-842. doi: 10.2217/imt-2022-0075. Epub 2022 Jun 27. PMID: 35757836.

89. Veytia-Bucheli JI, Alvarado-Velázquez DA, Possani LD, González-Amaro R, Rosenstein Y. The Ca2+ Channel Blocker Verapamil Inhibits the In Vitro Activation and Function of T Lymphocytes: A 2022 Reappraisal. Pharmaceutics. 2022 Jul 15;14(7):1478. doi: 10.3390/pharmaceutics14071478. PMID: 35890372; PMCID: PMC9324055.

90. Auvynet C, Rosenstein Y, Chemtob S. Use of small peptides in the treatment of inflammatory diseases. Front. Pharmacol., Sec. Inflammation Pharmacology, doi: 10.3389/fphar.2022.1090014, 2022

91. Rosenstein Y., Auvynet C.: Las ranas: de la medicina tradicional a nuevos fármacos, Biotecmov 31:3, www.biotecmov.ibt.unam.mx/numeros/31/3.html, 2022, 2022

92. Mendoza-Portillo E, Aleman-Navarro E, Prieto GA, Rosenstein Y, Lozano-Nuevo JJ, Perez-Lopez A Neurological manifestations with jugular vein thrombosis linked to an inflammatory profile may be a sequela of long COVID Neuroprotection;1‐6. https://doi.org/10.1002/nep3.24, 2023

93. Lacombe C, Aleman-Navaro E, Drujon T, Martinez-Osorio V, Sachon E, Melchy-Perez E, Carlier L, Fajardo Brigido LE, Fleury Y, Piesse C, Gutierrez-Escobedo G, De las Peñas A, Castaño I, Desriac F, Beristain-Hernandez JL, Combadiere C, Rosenstein Y, and Auvynet C. Characterization of a New Immunosuppressive and Antimicrobial Peptide, DRS-DA2, Isolated from the Mexican Frog, Pachymedusa dacnicolor," International Journal of Inflammation, vol. 2024, Article ID 2205864, 18 pages, 2024. https://doi.org/10.1155/2024/2205864

94. Sandoval-Hernández MA, Fierro NA, Veytia-Bucheli JI, Alvarado-Velázquez DA, Alemán-Navarro E, Melchy-Pérez E, Auvynet C, Imaz-Rosshandler I, Carneiro J, Perez-Rueda E & Rosenstein Y. Differential Impact of CD43 and CD28 on T-Cell Differentiation Depending on the Order of Engagement with the TCR, , International Journal of Molecular Sciences, 25: 3135, 2024 https://doi.org/10.3390/ ijms25063135

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx