Estudio de los factores asociados a la resistencia y susceptibilidad a la cisticercosis: factores del
parásito, del hospedero y de la relación hospedero-parásito
Estudio de las propiedades inmunomoduladoras de moléculas de origen infeccioso y no infeccioso:
a) potenciación de la respuesta inmune para la optimización de vacunas
b) Control de la inflamación en procesos autoinmunes y en procesos inflamatorios de bajo grado
Control de la neuroinflamación

Publicaciones

Garfias S, Tamaya Domínguez B, Toledo Rojas A, Arroyo M, Rodríguez U, Boll C, Sosa AL, Sciutto E, Adalid-Peralta L, Martinez López Y, Fragoso G, Fleury A. Peripheral blood lymphocyte phenotypes in Alzheimer and Parkinson's diseases. Neurologia. 11.pii: S0213-4853(19)30013-1. 2019. DOI: 10.1016/j.nrl.2018.10.004. FI: 2.9

Cervantes-Torres J, Gracia-Mora I, Segura-Velazquez R, Montero-Montoya R, Espinosa-Aguirre J, E Gonsebatt M, Camacho-Carranza R, Rivera-Huerta M, Sanchez-Bartez F, Tinoco-Méndez M, Ostrosky-Wegman P, Fragoso G, Sciutto E. Preclinical evidences of safety of a new synthetic adjuvant to formulate with the influenza human vaccine: absence of subchronic toxicity and mutagenicity. Immunopharmacol Immunotoxicol. 4:1-10. 2019. DOI: 10.1080/08923973.2019.1566359. FI: 2.9

De la Rosa-Ruiz MDP, Álvarez-Pérez MA, Cortés-Morales VA, Monroy-García A, Mayani H, Fragoso-González G, Caballero-Chacón S, Diaz D, Candanedo-González F, Montesinos JJ. Mesenchymal Stem/Stromal Cells Derived from Dental Tissues: A Comparative In Vitro Evaluation of Their Immunoregulatory Properties Against T cells. Cells. 22;8(12):1491. 2019. DOI: 10.3390/cells8121491. FI: 5.1

Álvarez-Luquín DD, Arce-Sillas A, Leyva-Hernández J, Sevilla-Reyes E, Boll MC, Montes-Moratilla E, Vivas-Almazán V, Pérez-Correa C, Rodríguez-Ortiz U, Espinoza-Cárdenas R, Fragoso G, Sciutto E, Adalid-Peralta L. Regulatory impairment in untreated Parkinson's disease is not restricted to Tregs: other regulatory populations are also involved. J Neuroinflammation. 6(1):212. 2019. DOI: 10.1186/s12974-019-1606-1. FI: 9.3

Villegas M, Sciutto E, Rosetti M, Fleury A, Fragoso G. (Corresponding author) Association of TRAF1/C5 Locus Polymorphisms with Epilepsy and Clinical Traits in Mexican Patients with Neurocysticercosis. Infect Immun. 18;87(12):e00347-19. 2019. DOI: 10.1128/IAI.00347-19. FI: 2.9

Méndez-Martínez M, Trejo-Moreno C. Maldonado-Mejía L, Esquivel-Guadarrama F, Pedraza-Chaverri J, Zamilpa A, Medina-Campos O, Alarcón-Aguilar F, Almanza-Pérez JC, Contreras-Nuñez E, Santana-Calderón A, Fragoso G, Jiménez-Ferrer E, Rosas G. Effect of Cucumis sativus on Dysfunctional 3T3-L1 Adipocytes. Sci Rep. 16;9(1):13372. 2019. DOI: 10.1038/s41598-019-49458-6. FI: 3.8

Arce-Sillas A, Sevilla-Reyes E, Álvarez-Luquín DD, Guevara-Salinas A, Boll MC, Pérez-Correa CA, Vivas-Almazan AV, Rodríguez-Ortiz U, Castellanos Barba C, Hernandez M, Fragoso G, Sciutto E, Cárdenas G, Adalid-Peralta LV. Expression of Dopamine Receptors in Immune Regulatory Cells. Neuroimmunomodulation. 2019;26(3):159-166. 2019. DOI: 10.1159/000501187. FI: 2.2

Rodríguez-Rodríguez N, Madera-Salcedo IK, Bugarin-Estrada E, Sánchez-Miranda E, Torres-García D, Cervantes-Torres J, Fragoso G, Rosetti F, Crispín JC, Sciutto E. The helminth-derived peptide GK-1 induces an anti-tumoral CD8 T cell response associated with downregulation of the PD-1/PD-L1 pathway. Clin Immunol. 212:108240. 2020. DOI: 10.1016/j.clim.2019.07.006. FI: 4.5

Montero L, Cervantes-Torres J, Sciutto E, Fragoso G. (Corresponding author). Helminth-derived peptide GK-1 induces Myd88-dependent pro-inflammatory signaling events in bone marrow-derived antigen-presenting cells. Mol Immunol. 128:22-32. 2020. DOI: 10.1016/j.molimm.2020.09.015. FI: 3.2

Espinosa-Cárdenas R, Arce-Sillas A, Álvarez-Luquin D, Leyva-Hernández J, Montes-Moratilla E, González-Saavedra I, Boll MC, Garcia-Garcia E, Ángeles-Perea S, Fragoso G, Sciutto E, Adalid-Peralta L. Immunomodulatory effect and clinical outcome in Parkinson's disease patients on levodopa-pramipexole combo therapy: A two-year prospective study. J Neuroimmunol. 15;347:577328. 2020. DOI: 10.1016/j.jneuroim.2020.577328. FI: 2.9

Espinosa A, Meneses G, Chavarría A, Mancilla R, Pedraza-Chaverri J, Fleury A, Bárcena B, Pérez-Osorio IN, Besedovsky H, Arauz A, Fragoso G, Sciutto E. Intranasal Dexamethasone Reduces Mortality and Brain Damage in a Mouse Experimental Ischemic Stroke Model. Neurotherapeutics. 17(4):1907-1918. 2020. DOI: 10.1007/s13311-020-00884-9. FI: 5.6

Rassy D, Bárcena B, Pérez-Osorio IN, Espinosa A, Peón AN, Terrazas LI, Meneses G, Besedovsky HO, Fragoso G, Sciutto E. Intranasal Methylprednisolone Effectively Reduces Neuroinflammation in Mice With Experimental Autoimmune Encephalitis. J Neuropathol Exp Neurol. 79(2):226-237. 2020. DOI: 10.1093/jnen/nlz128. FI: 3.2

Trejo-Moreno C, Jiménez-Ferrer E, Castro-Martínez G, Méndez-Martínez M, Santana MA, Arrellín-Rosas G, Pedraza-Chaverri J, Medina-Campos ON, Hernández-Téllez B, Ramírez-Pliego O, Herrera-Ruiz M, Cervantes-Torres J, Alvarado-Ojeda ZA, Costet-Mejía A, Fragoso G, Rosas-Salgado G. Characterization of a murine model of endothelial dysfunction induced by chronic intraperitoneal administration of angiotensin II. Sci Rep. 27;11(1):21193. 2021. DOI: 10.1038/s41598-021-00676-x. FI: 3.8

Toledo A, Orozco-Suárez S, Rosetti M, Maldonado L, Bautista SI, Flores X, Arellano A, Moreno S, Alonso M, Martínez-Juárez IE, Fragoso G, Sciutto E, Fleury A. Temporal lobe epilepsy: Evaluation of central and systemic immune-inflammatory features associated with drug resistance. Seizure. 91:447-455. 2021. DOI: 10.1016/j.seizure.2021.07.028. FI: 2.7

Voutssas-Lara J, Cervantes-Torres J, Hernández M, Bobes RJ, Lamoyi E, Vázquez-Ramírez RA, Mendoza L, Reyes-Barrera KL, López-Martínez R, Alpuche-Solís ÁG, Rosales-Mendoza S, Huerta L, Fragoso G, Sciutto E. Influence of adjuvants on the amount, specificity and functional activity of antibody response to human influenza vaccine in mice. Mol Immunol. 135:398-407. 2021. DOI: 10.1016/j.molimm.2021.05.003. FI: 3.2

Adalid-Peralta L, Lopez-Roblero A, Camacho-Vázquez C, Nájera-Ocampo M, Guevara-Salinas A, Ruiz-Monroy N, Melo-Salas M, Morales-Ruiz V, López-Recinos D, Ortiz-Hernández E, Demengeot J, Vazquez-Perez JA, Arce-Sillas A, Gomez-Fuentes S, Parkhouse RME, Fragoso G, Sciutto E, Sevilla-Reyes EE. Regulatory T Cells as an Escape Mechanism to the Immune Response in Taenia crassiceps Infection. Front Cell Infect Microbiol. 11:630583. 2021. DOI: 10.3389/fcimb.2021.630583. FI: 4.6

Hamamoto Filho PT, Fragoso G, Sciutto E, Fleury A. Inflammation in neurocysticercosis: clinical relevance and impact on treatment decisions. Expert Rev Anti Infect Ther. 19(12):1503-1518. 2021. DOI: 10.1080/14787210.2021.1912592. FI: 4.2

Gomez-Fuentes S, Hernández-de la Fuente S, Morales-Ruiz V, López-Recinos D, Guevara-Salinas A, Parada-Colin MC, Espitia C, Ochoa-Leyva A, Sánchez F, Villalobos N, Arce-Sillas A, Hernández M, Mora SI, Fragoso G, Sciutto E, Adalid-Peralta L. A novel, sequencing-free strategy for the functional characterization of Taenia solium proteomic fingerprint. PLoS Negl Trop Dis. 15(2):e0009104. 2021. DOI: 10.1371/journal.pntd.0009104. FI: 3.4

Fragoso G, Sciutto E. GK1: An Alternative Treatment to Control the Respiratory Complications During COVID19. Arch Med Res. 52(3):354-355. 2021. DOI: 10.1016/j.arcmed.2020.10.019. FI: 4.7

Garfias S, Tamaya Domínguez B, Toledo Rojas A, Arroyo M, Rodríguez U, Boll C, Sosa AL, Sciutto E, Adalid-Peralta L, Martinez López Y, Fragoso G, Fleury A. Peripheral blood lymphocyte phenotypes in Alzheimer and Parkinson's diseases. Neurologia (Engl Ed). 37(2):110-121. 2022. DOI: 10.1016/j.nrleng.2018.10.022. FI: 2.9

Cárdenas G, Torres-García D, Cervantes-Torres J, Rosales-Mendoza S, Fleury A, Fragoso G, Laclette JP, Sciutto E. Role of Systemic and Nasal Glucocorticoid Treatment in the Regulation of the Inflammatory Response in Patients with SARS-Cov-2 Infection. Arch Med Res. 52(2):143-150. 2021. DOI: 10.1016/j.arcmed.2020.10.014. FI: 4.7

Cárdenas G, Chávez-Canales M, Espinosa AM, Jordán-Ríos A, Malagon DA, Murillo MFM, Araujo LVT, Campos RLB, Wong-Chew RM, González LER, Cresencio KI, Velázquez EG, de la Cerda MR, Leyva Y, Hernández-Ruiz J, Hernández-Medel ML, León-Hernández M, Quero KM, Monciváis AS, Díaz SH, Martínez IRZ, Martínez-Cuazitl A, Salazar INM, Sarmiento EB, Peña AF, Hernández PS, Reynoso RIA, Reyes DM, Del Río Ambriz LR, Bonilla RAA, Cruz J, Huerta L, Fierro NA, Hernández M, Pérez-Tapia M, Meneses G, Espíndola-Arriaga E, Rosas G, Chinney A, Mendoza SR, Hernández-Aceves JA, Cervantes-Torres J, Rodríguez AF, Alor RO, Francisco SO, Salazar EA, Besedovsky H, Romano MC, Bobes RJ, Jung H, Soldevila G, López-Alvarenga J, Fragoso G, Laclette JP, Sciutto E. Intranasal dexamethasone: a new clinical trial for the control of inflammation and neuroinflammation in COVID-19 patients. Trials. 23(1):148. 2022. DOI: 10.1186/s13063-022-06075-5. FI: 2.0

Cárdenas G, Fragoso G, Sciutto E. Neuroinflammation in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection: Pathogenesis and clinical manifestations, Curr Opin Pharmacol. 63:102181. 2022. DOI: 10.1016/j.coph.2021.12.008. FI: 4.0

Contreras-Luna MJ, Fragoso-González G, Segura-Velázquez RA, Cervantes-Torres JB, Alonso-Morales R, Ramírez-Martínez LA, Ayón-Núñez DA, Bobes RJ, Sánchez-Betancourt JI. Immunogenic and antigenic analysis of recombinant NSP1 and NSP11 of PRRS virus. Vet Med Sci. 8(2):610-618. 2022. DOI: 10.1002/vms3.699. FI: 1.8

Cervantes-Torres J, Rosales-Mendoza S, Cabello C, Montero L, Hernandez-Aceves J, Granados G, Calderón-Gallegos A, Zúñiga-Flores F, Ruiz-Rivera M, Abarca-Magaña JC, Ortega-Francisco S, Olguin-Alor R, Díaz G, Paczka-Garcia F, Zavala-Gaytan R, Vázquez-Ramírez R, Ayón-Nuñez DA, Carrero JC, Rios D, Jasso-Ramírez M, Vázquez-Hernández R, Venegas D, Garzón D, Cobos L, Segura-Velázquez R, Villalobos N, Meneses G, Zúñiga J, Gamba G, Cárdenas G, Hernández M, Parkhouse ME, Romano MC, Alonso Herrera L, Bobes RJ, Pérez-Tapia M, Huerta L, Fierro N, Gracia I, Soldevilla G, Fragoso G, Suárez-Güemes F, Laclette JP, Sciutto E. Towards the development of an epitope-focused vaccine for SARS-CoV-2. Vaccine. 40(45):6489-6498. 2022. DOI: 10.1016/j.vaccine.2022.09.059. FI: 4.5

Cruz-Gregorio A, Aranda-Rivera AK, Sciutto E, Fragoso G, (Co-corresponding author) Pedraza-Chaverri J. Redox state associated with antitumor and immunomodulatory peptides in cancer. Arch Biochem Biophys. 730:109414. 2022. DOI: 10.1016/j.abb.2022.109414. FI: 3.8

Ortiz Caltempa A, Hernández M, Pérez AL, Aguilar L, Guzmán C, Ayón-Núñez DA, Fragoso G, Bobes RJ, López ME, Sciutto E, Villareal ML. Improvement of cell suspension cultures of transformed and untransformed Carica papaya cell lines, towards the development of an antiparasitic product against the gastrointestinal nematode Haemonchus contortus. Front Cell Infect Microbiol. 8;12:958741. 2022. DOI: 10.3389/fcimb.2022.958741. FI: 4.6

Ayón-Núñez DA, Cervantes-Torres J, Cabello-Gutiérrez C, Rosales-Mendoza S, Rios-Valencia D, Huerta L, Bobes RJ, Carrero JC, Segura-Velázquez R, Fierro NA, Hernández M, Zúñiga-Ramos J, Gamba G, Cárdenas G, Frías-Jiménez E, Herrera LA, Fragoso G, Sciutto E, Suárez-Güemes F, Laclette JP. An RBD-Based Diagnostic Method Useful for the Surveillance of Protective Immunity against SARS-CoV-2 in the Population. Diagnostics (Basel). 12(7):1629. 2022. DOI: 10.3390/diagnostics12071629. FI: 3.0

Giraldo-Velásquez MF, Pérez-Osorio IN, Espinosa-Cerón A, Bárcena BM, Calderón-Gallegos A, Fragoso G, Torres-Ramos M, Páez-Martínez N, Sciutto E. Intranasal Methylprednisolone Ameliorates Neuroinflammation Induced by Chronic Toluene Exposure. Pharmaceutics. 14(6):1195. 2022. DOI: 10.3390/pharmaceutics14061195. FI: 4.9

Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Medina-Campos ON, Sciutto E, Fragoso G, (Co-corresponding author) Pedraza-Chaverri J. GK-1 Induces Oxidative Stress, Mitochondrial Dysfunction, Decreased Membrane Potential, and Impaired Autophagy Flux in a Mouse Model of Breast Cancer. Antioxidants (Basel). 12(1):56. 2022. DOI: 10.3390/antiox12010056 FI: 6.0

Cárdenas G, Bobes RJ, Fragoso G, Pérez-Osorio NI, Hernández M, Espinosa A, Fleury A, Flores J, The Revival Project Consortium, Laclette JP, Sciutto E, Jung-Cook H. Pharmacokinetic Study of Intranasal Dexamethasone and Methylprednisolone Compared with Intravenous Administration: Two Open-Label, Single-Dose, Two-Period, Two-Sequence, Cross-Over Study in Healthy Volunteers. Pharmaceutics. 15(1):105. 2022. DOI: 10.3390/pharmaceutics15010105. FI: 4.9

Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Medina-Campos ON, Sciutto E, Fragoso G, Pedraza-Chaverri J. α-Mangostin induces oxidative damage, mitochondrial dysfunction, and apoptosis in a triple-negative breast cancer model. Phytother Res. 37(8):3394-3407. 2023. DOI: 10.1002/ptr.7812. FI: 6.1

Guzmán C, Villalobos N, Ortiz Caltempa A, Hernández M, Núñez G, Salazar J, Bobes RJ, Fragoso G, Sciutto E, Villarreal ML. In Vitro and In Vivo Cysticidal Effects of Carica Papaya Cell Suspensions. Infect Immun. 91(7):e0051722. 2023. DOI: 10.1128/iai.00517-22. FI: 2.9

Romo ML, Osorio R, Toledo A, Carrillo-Mezo R, Valdez R, Romano MC, Sciutto E, Fragoso G, Fleury A. Low responsiveness of peripheral lymphocytes in extraparenchymal neurocysticercosis. PLoS Negl Trop Dis. 1;17(6):e0011386. 2023. DOI: 10.1371/journal.pntd.0011386. FI: 3.4

Espinosa-Cerón A, Méndez A, Hernández-Aceves J, Juárez-González JC, Villalobos N, Hernández M, Díaz G, Soto P, Concha L, Pérez-Osorio IN, Ortiz-Retana JJ, Bobes RJ, Parkhouse RM, Hamamoto Filho PT, Fragoso G, Sciutto E. Standardizing an Experimental Murine Model of Extraparenchymal Neurocysticercosis That Immunologically Resembles Human Infection. Brain Sci. 13(7):1021. 2023. DOI: 10.3390/brainsci13071021. FI: 2.7

Toledo, A.; Fragoso, G.; Carrillo-Mezo, R.; Romo, M.L.; Sciutto, E.; Fleury, A. Can sPD-1 and sPD-L1 Plasma Concentrations Predict Treatment Response among Patients with Extraparenchymal Neurocysticercosis? Pathogens 12(9):1116. 2023. DOI: 10.3390/pathogens12091116 FI: 3.3

Hernández-Aceves JA, Cervantes-Torres J, Torres-García D, Zuñiga-Flores FJ, Patiño-Chávez OJ, Peña Agudelo JA, Aguayo-Flores JE, Garfias Y, Montero-León L, Romero-Romero L, Pérez-Torres A, Fragoso G, (co-corresponding author), Sciutto E. GK-1 effectively reduces angiogenesis and prevents T cell exhaustion in a breast cancer murine experimental model. Cancer Immunol Immunother. 72(11):3825-38382023 DOI: 10.1007/s00262-023-03538-9 FI: 4.6

Trejo-Moreno C, Alvarado-Ojeda ZA, Méndez-Martínez M, Cruz-Muñoz ME, Castro-Martínez G, Arrellín-Rosas G, Zamilpa A, Jimenez-Ferrer JE, Baez Reyes JC, Fragoso G. (co-corresponding author), Salgado GR. Aqueous Fraction from Cucumis sativus Aerial Parts Attenuates Angiotensin II-Induced Endothelial Dysfunction In Vivo by Activating Akt. Nutrients. 15(21):4680. 2023. DOI: 10.3390/nu15214680. FI: 4.8

Cárdenas G, Chávez-Canales M, Espinosa AM, Jordán-Ríos A, Malagon DA, Murillo MFM, Araujo LVT, Campos RLB, Wong-Chew RM, González LER, Cresencio KI, Velázquez EG, de la Cerda MR, Leyva Y, Hernández-Ruiz J, Hernández-Medel ML, León-Hernández M, Quero KM, Monciváis AS, Sarmiento EB, Reynoso RIA, Reyes DM, Del Río Ambriz LR, Hernández JSG, Cruz J, Ferrer SIV, Huerta L, Fierro NA, Hernández M, Pérez-Tapia M, Meneses G, Rosas G, Hernández-Aceves JA, Cervantes-Torres J, Valdez RA, Rodríguez AF, Espíndola-Arriaga E, Ortiz M, Salazar EA, Barba CC, Besedovsky H, Romano MC, Jung H, Bobes RJ, Soldevila G, López-Alvarenga JC, Fragoso G, Laclette JP, Sciutto E. Intranasal Versus Intravenous Dexamethasone to Treat Hospitalized COVID-19 Patients: A Randomized Multicenter Clinical Trial. Arch Med Res. 55(2):102960. 2024. DOI: 10.1016/j.arcmed.2024.102960. FI: 4.7

Aziel Alvarado-Ojeda Z, Zamilpa A, Costet-Mejia A, Méndez-Martínez M, Trejo-Moreno C, Jiménez-Ferrer JE, Salazar-Martínez AM, Cruz-Muñoz ME, Fragoso G, (co-corresponding author), Rosas-Salgado G. Hydroalcoholic extract from Sechium edule (Jacq.) S.w. root reverses oleic acid-induced steatosis and insulin resistance in vitro. Heliyon 10(2):e24567. 2024. DOI: 10.1016/j.heliyon.2024.e24567. FI: 3.4

Alvarado-Ojeda ZA, Trejo-Moreno C, Ferat-Osorio E, Méndez-Martínez M, Fragoso G, Rosas-Salgado G. Role of Angiotensin II in Non-Alcoholic Steatosis Development. Arch Med Res. 55(3):102986. 2024. DOI: 10.1016/j.arcmed.2024.102986. FI: 4.7

Cervantes-Torres J, Cabello-Gutiérrez C, Ayón-Núñez DA, Soldevila G, Olguin-Alor R, Diaz G, Acero G, Segura-Velázquez R, Huerta L, Gracia-Mora I, Cobos L, Pérez-Tapia M, Almagro JC, Suárez-Güemes F, Bobes RJ, Fragoso G, Sciutto E, Laclette JP. Caveats of chimpanzee ChAdOx1 adenovirus-vectored vaccines to boost anti-SARS-CoV-2 protective immunity in mice. Appl Microbiol Biotechnol. 108(1):179. 2024. DOI: 10.1007/s00253-023-12927-0. FI: 3.9

Arce-Sillas A, Álvarez-Luquín DD, Leyva-Hernández J, Montes-Moratilla E, Vivas-Almazán V, Pérez-Correa C, Rodríguez-Ortiz U, Espinosa-Cárdenas R, Fragoso G, Sciutto E, Adalid-Peralta L. Increased levels of regulatory T cells and IL-10-producing regulatory B cells are linked to improved clinical outcome in Parkinson's disease: a 1-year observational study. J Neural Transm (Vienna). 131(8):901-916. 2024. DOI: 10.1007/s00702-024-02790-2. FI: 3.2

Méndez-Martínez M, Zamilpa A, Zavala-Sánchez MA, Almanza-Pérez JC, Jiménez-Ferrer JE, Herrera-Ruiz M, González-Cortázar M, Cervantes-Torres J, Fragoso G, (Co-corresponding author), Rosas-Salgado G. Anti-adipogenic effect of Malva parviflora on 3T3-L1 adipocytes. PLoS One. 8;19(8):e0306903. 2024. DOI: 10.1371/journal.pone.0306903. FI: 2.9

Poblano-Pérez, L.I.; Monroy-García, A.; Fragoso-González, G.; Mora-García, M.d.L.; Castell-Rodríguez, A.; Mayani, H.; Álvarez-Pérez, M.A.; Pérez-Tapia, S.M.; Macías-Palacios, Z.; Vallejo-Castillo, L.; Montesinos, J.J. Mesenchymal Stem/Stromal Cells Derived from Dental Tissues Mediate the Immunoregulation of T Cells through the Purinergic Pathway. Int. J. Mol. Sci.. 25(17):9578. 2024. DOI: 10.3390/ijms25179578. FI 4.9

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx