1. Mechanisms involved in the development of chronic kidney disease (CKD) induced by a period of acute kidney injury (AKI).
2. Aldosterone and receptor mineralocorticoids in the pathophysiology of renal diseases.
3. Molecular Physiology and pathophysiology of renal heat shock proteins.
4. New biomarkers for detecting kidney damage.
5. Searching of the actions of serpina A3 in the kidney diseases of different
etiologies
5. Translational Research.

Publicaciones

1) Transient inhibition of Sodium-Glucose Cotransporter 2 after ischemia/reperfusion Injury Ameliorates Chronic Kidney Disease. Martínez-Rojas MA, Balcázar H, González-Soria I, González-Rivera JM, Rodríguez-Vergara ME, Velazquez-Villegas LA, León-Contreras JC, Pérez-Villalva R, Correa F, Rosetti F, and Bobadilla NA. (Autora Corresponsal). JCI insight 9(6):e173675 2024. FI 6.2
2) A short treatment with Resveratrol after a renal ischemia/reperfusion injury prevents maladaptive repair and long-term chronic kidney disease in rats. Martínez Rojas MA, Balcázar H, Ponce-Nava MS, González-Soria I, Marquina-Castillo B, Pérez-Villalva R, Bobadilla NA. (Autora Corresponsal). J of Physiol Apr;602(8):1835-1852 2024. FI 4.7
3) KS-WNK1 is Required for the Renal Response to Extreme Changes in Potassium Intake. Bahena-Lopez JP, Vergara L, de-la-Peña V, López-Ibargüen P, Gallardo-Gutiérrez MA, García JA, Contreras-Carbajal H, VázquezN, Rincón-Heredia R, Masso F, Bobadilla NA, Castañeda-Bueno M, Ellison DH, Gamba G, Chávez-Canales M. Am J Physiol Renal Physiol 326: F460–F476, 2024. FI 3.7
4) Is renal ischemic preconditioning an alternative to ameliorate the short and long consequences of acute kidney injury? Ortega-Trejo JA and Bobadilla NA. (Autora Corresponsal). Int. J. Mol. Sci. 24(9), 8345, 2023. FI 5.6
5) SerpinA3K deficiency reduces oxidative stress in acute kidney injury González-Soria I, Soto-Valadez AD, Martínez-Rojas MA, Ortega-Trejo JA, Pérez-Villalva R, Gamba G, Sánchez-Navarro A, and Bobadilla NA (Autora Corresponsal). Int. J. Mol. Sci. 24(9), 7815, 2023. FI 5.6
6) Zúñiga-Macías LP, Ramírez-Orozco RE, Avelar-González FJ, Pérez-Villalva R, Bobadilla NA, Arreola-Guerra JM. SerpinA3 is associated with persistent albuminuria in adolescents with secondary podocytopathy in a region with high prevalence or cronic kidney Disease of unknown origin. Rev. Inv. Clin and translational Res 75(2), 53-62, 2023. FI 1.4
7) Repeated episodes ischemia/reperfusion induce inflammation and protect against chronic kidney injury. Ortega-Trejo JA, Pérez-Villalva R, Sánchez-Navarro A, Marquina B, Rodríguez-Iturbe B, Bobadilla NA (Autora Corresponsal). Int J Mol Sci 23(23), 14573, 2022. FI 5.6
8) Martínez-Rojas MA, Sánchez-Navarro A, Mejia-Vilet JM, Pérez-Villalva R, Uribe N, and Bobadilla NA (Autora Corresponsal). Urinary Serpin-A3 is an early predictor of clinical response to therapy in patients with proliferative Lupus Nephritis. Am J Physiol-Renal Physiol 323(4):F425-F434, 2022. FI 4.2
9) Sánchez-Navarro A, Martínez-Rojas MA, Albarrán-Godinez A, Pérez-Villalva R, Auwerx J, de la Cruz A, Noriega LG, Rosetti F, and Bobadilla NA (Autora Corresponsal). Sirtuin 7 deficiency reduces inflammation and tubular damage induced by an episode of acute kidney injury. Int J Mol Sci 23(5), 2573, 2022. FI 5.6
10) Sánchez-Navarro A, Murillo-de-Ozores AR, Pérez-Villalva R, Linares N, Carbajal-Contreras H, Flores ME, Gamba G, Castañeda-Bueno M, and Bobadilla NA (Autora Corresponsal). Transient response of serpinA3 during cellular stress. FASEB J 36(3):e22190.2022. FI 4.8
11) Catalán R, Jiménez-Ceja JV, Rincón-Pedrero R, Olivas-Martínez A, Martínez-Rueda AJ, Bazúa-Valenti S, Carrillo-Pérez DL, Grajeda-Medina LI, García-Juárez I, Vilatobá M, Ortega-Trejo JA, Pérez-Villalva R, Bobadilla NA, Moreno E, Gamba G. Factors Associated with Development of Acute Kidney Injury After Liver Transplantation. Rev Invest Clin. 74(2), 90-96, 2022. FI 1.4
12) Sánchez-Navarro A, Martínez-Rojas MA, Caldiño-Bohn R.I. Pérez-Villalva R, Zambrano E,. Castro-Rodríguez DC, and Bobadilla NA (Autora Corresponsal). Early riggers of moderately high-fat diet-induced kidney damage. Physiol Rep 9:e14937, 1-13, 2021. FI 2.5
13) Sánchez-Navarro A, Pérez-Villalva R, Murillo-de-Ozores AR, Martínez MA, Rodríguez‐Aguilera JR, Ortega E, Castañeda-Bueno M, Gamba G, Recillas-Targa F, Bobadilla NA. (Autora Corresponsal). Vegfa promoter gene hypermethylation at HIF1α binding site is an early contributor to CKD progression after renal ischemia. Sci Rep 22;11(1):8769, 2021. FI 4.6
14) Sanchéz-Navarro A, González-Soria I, and Bobadilla NA (Autora Corresponsal). An integrative view of serpins in health and Disease: contribution of serpinA3. Am J Physiol – Cell Physiol 320: C106–C118, 2021. FI 5.5
15) Ostrosky-Frid M, Chavez-Canales M, Zhang J, Andrukova O, Argaiz E, Lerdo de Tejada F, Murillo-de-Ozores A, Sanchez-Navarro A, Rojas-Vega L, Bobadilla N.A, Vazquez N, Castaneda-Bueno M, Alessi D, Gerardo Gamba: Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression. Am J Physiol-Renal Physiol 1;320(5):F734-F747, 2021. FI 4.2
16) Lima-Posada I and Bobadilla NA. Understanding the opposite effects of sex hormones in mediating renal injury. (Autora Corresponsal). Nephrology (Carlton). 26:217-226, 2021. doi: 10.1111/nep.13806. FI 2.5
17) Díaz L, Zambrano E, Flores ME, Contreras M, Crispín JC, Alemán G, Bravo C, Armenta A, Valdés VJ, Tovar A, Gamba G, Barrios-Payán J , and Bobadilla NA (Autora Corresponsal). I. Ethical Considerations in Animal Research: The principle of 3R´s. Rev Inv Clin 73(4): 199-209, 2021. FI 1.4
18) Ortega-Trejo JA, Pérez-Villalva R, Arreola-Guerra JM, Ramírez V, Sifuentes-Osornio J, and Bobadilla NA (Autora Corresponsal). Effect of Fosfomycin on Cyclosporine Nephrotoxicity. Antibiotics, 9:720, 1-14, 2020. FI 4.8
19) Martínez-Rojas MA, Vega-Vega O, Bobadilla NA (Autora Corresponsal). Is the kidney a target of SARS-CoV-2?" Am J Physiol-Renal Physiol. 318(6): F454-F462, 2020. ISSN: 1522-1466. FI 4.2
20) García-Ortuño LE, Barrera-Chimal J, Pérez-Villalva R, Ortega-Trejo JA, Luna-Bolaños E, Lima-Posada I, Sánchez Navarro A, Reyes-Castro L, Gamba G, Zambrano E, and Bobadilla NA (Autora Corresponsal). Resilience to acute kidney injury in offspring of maternal protein restriction. Am J Physiol-Renal Physiol. 317(6):F1637-F1648, 2019. ISSN: 1522-1466. FI 4.2
21) Sánchez-Navarro A, Pérez-Villalva R, Mejía-Vilet JM, Carrillo-Pérez DL, Gamba G, Bobadilla NA (Autora Corresponsal). SerpinA3 in the Early Recognition of Acute Kidney Injury to Chronic Kidney Disease (CKD) transition in the rat and its Potentiality in the Recognition of Patients with CKD. Sci Rep. 9(1):10350, 2019. ISSN: 2045-2322. FI 4.6
22) Morales-Buenrostro LE, Ortega-Trejo JA, Pérez-Villalva R, Marino LA, González-Bobadilla Y, Juárez H, Zamora-Mejía FM, González N, Espinoza R, Barrera-Chimal J and Bobadilla NA (Autora Corresponsal). Spironolactone reduces oxidative stress in living donor kidney transplantation: a randomized controlled trial. Am J Physiol-Renal Physiol. 317(3): F519-F528, 2019. ISSN: 1522-1466 FI 4.2
23) Barrera-Chimal J, Rocha L., Amador-Martínez I, Pérez-Villalva R, Gonzalez R., Cortés-González C, Uribe N, Berman N, Gamba G, Bobadilla NA (Autora Corresponsal). Delayed spironolactone administration prevents the transition from acute kidney injury to chronic kidney disease through improving renal inflammation. Nephrol Dial Transpl 34(5):794-801, 2019. ISSN: 0931-0509, FI 6.1
24) Amador-Martínez I, Pérez-Villalva R, Uribe N, Cortés-González CC, Bobadilla NA, Barrrera-Chimal J. Reduced endothelial nitric oxide synthase activation contributes to cardiovascular injury during chronic kidney disease progression. Am J Physiol-Renal Physiol 317(2):F275-F285, 2019. ISSN: 1522-1466. ISSN: 1522-1466 FI 4.2
25) Lima-Posada I, Fontana F, Pérez-Villalva R, Berman-Parks N and Bobadilla NA (Autora Corresponsal). Pirfenidone prevents Acute Kidney Injury in the Rat. BMC Nephrol. 20(1):158, 2019. ISSN: 1471-2369. FI 2.3

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx