-Identificación de antígenos y epítopes protectores contra la cisticercosis

-Diagnóstico de la cisticercosis humana y porcina

-Relevancia de los factores genéticos e inmunológicos en un modelo experimental de cisticercosis

-Desarrollo de adyuvantes

-Hacia el control de la cisticercosis a través del desarrollo de vacunas, métodos diagnósticos y estudios epidemiológicos

-Epidemiología de las enfermedades neurológicas de medio rural

-Relevancia de factores genéticos, inmunológicos y sexuales en la neurocisticercosis humana

Publicaciones

1. Arce-Sillas A, Álvarez-Luquín DD, Cárdenas G, Casanova-Hernández D, Fragoso G, Hernández M, Proaño Narváez JV, García-Vázquez F, Fleury A, Sciutto E, Adalid-Peralta L. IL-10 and dendritic cells are the main suppression mediators of regulatory T cells in human neurocysticercosis. Clin Exp Immunol. 2016; 183(2): 271-9. doi: 10.1111/cei.12709. FI 3.532
2. Cárdenas G, Guevara-Silva E, Romero F, Ugalde Y, Bonnet C, Fleury A, Sciutto E, Nunes CM, Soto-Hernández JL, Shankar SK, Mahadevan A. Spinal Taenia solium cysticercosis in Mexican and Indian patients: a comparison of 30-year experience in two neurological referral centers and review of literature. Eur Spine J. 2016; 25(4): 1073-81. doi: 10.1007/s00586-015-4271-9. FI 2.620
3. Monreal-Escalante E, Govea-Alonso DO, Hernández M, Cervantes J, Salazar-González JA, Romero-Maldonado A, Rosas G, Garate T, Fragoso G, Sciutto E, Rosales-Mendoza S. Towards the development of an oral vaccine against porcine cysticercosis: expression of the protective HP6/TSOL18 antigen in transgenic carrots cells. Planta. 2016; 243(3): 675-85. doi: 10.1007/s00425-015-2431-0. FI 3.110.
4. Fleury A, Cardenas G, Adalid-Peralta L, Fragoso G, Sciutto E. Immunopathology in Taenia solium neurocysticercosis. Parasite Immunol. 2016;38(3):147-57. doi: 10.1111/pim.12299. FI 2.054
5. Domínguez-Roldan R, Hallal-Calleros C, Sciutto E, Hernandez M, Aguirre-Flores V, García-Jiménez S, Baez-Saldaña A, Flores-Perez FI. Behavioral and hormonal changes associated with the infective dose in experimental taeniasis in golden hamsters (Mesocricetus auratus). Exp Parasitol 2016; 166: 173-80. FI 1.730
6. Navarrete-Perea J, Toledano-Magaña Y, Torre P, Sciutto E, Bobes RJ, Soberón X, Laclette JP. Role of porcine serum haptoglobin in the host-parasite relationship of Taenia solium cysticercosis. Mol Biochem Parasitol 2016; pii: S0166-6851(16)30061-5. doi: 10.1016/j.molbiopara.2016.05.010. FI 1.571
7. Meneses G, Bautista M, Florentino A, Díaz G, Acero G, Besedovsky H, Meneses D, Fleury A, Del Rey A, Gevorkian G, Fragoso G, Sciutto E. Electric stimulation of the vagus nerve reduced mouse neuroinflammation induced by lipopolysaccharide. J Inflamm (Lond). 2016 Oct 29. FI 4.953
8. Fleury A, Sastre P, Sciutto E, Correia S, Monedero A, Toledo A, Hernandez Maricela, Harrison LJS, Parkhouse RME. A lateral flow assay (LFA) for the rapid detection of extraparenchymal neurocysticercosis using cerebrospinal fluid. Exp Parasitol. 2016; 171: 67-70. FI 1.730
9. Navarrete-Perea J, Moguel B, Bobes RJ, Villalobos N, Carrero JC, Sciutto E, Soberón X, Laclette JP. Protein profiles of Taenia solium cysts obtained from skeletal muscles and the central nervous system of pigs: Search for tissue-specific proteins. Exp Parasitol. 2017 Jan; 172: 23-29. doi: 10.1016/j.exppara.2016.11.006. FI 1.730
10. Fragoso G, Hernández M, Cervantes-Torres J, Ramírez-Aquino R, Chapula H, Villalobos N, Segura-Velázquez R, Figueroa A, Flores I, Jiménez H, Adalid L, Rosas G, Galvez L, Pezzat E, Monreal-Escalante E, Rosales-Mendoza S, Vazquez LG, Sciutto E. Transgenic papaya: a useful platform for oral vaccines. Planta. 2017; 245(5): 1037-1048. doi: 10.1007/s00425-017-2658-z. FI 3.110
11. Marcin Sierra M, Arroyo M, Cadena Torres M, Ramírez Cruz N, García Hernández F, Taboada D, Galicia Martínez Á, Govezensky T, Sciutto E, Toledo A, Fleury A. Extraparenchymal neurocysticercosis: Demographic, clinicoradiological, and inflammatory features. PLoS Negl Trop Dis. 2017; 11(6): e0005646. doi: 10.1371/journal.pntd.0005646. FI 4.400
12. Cervantes-Torres J, Segura-Velázquez R, Padilla P, Sciutto E, Fragoso G. High stability of the immunomodulatory GK-1 synthetic peptide measured by a reversed phase high-performance liquid chromatography method. J Chromatogr B Analyt Technol Biomed Life Sci. 2017; 1060: 97-102. doi: 10.1016/j.jchromb.2017.05.027. FI 3.004
13. Peón AN, Ledesma-Soto Y, Olguín JE, Bautista-Donis M, Sciutto E, Terrazas LI. Helminth Products Potently Modulate Experimental Autoimmune Encephalomyelitis by Downregulating Neuroinflammation and Promoting a Suppressive Microenvironment. Mediators Inflamm. 2017;2017: 8494572. doi: 10.1155/2017/ 8494572. FI 3.360
14. Meneses G, Gevorkian G, Florentino A, Bautista MA, Espinosa A, Acero G, Díaz G, Fleury A, Pérez Osorio IN, Del Rey A, Fragoso G, Sciutto E, Besedovsky H. Intranasal delivery of dexamethasone efficiently controls LPS-induced murine neuroinflammation. Clin Exp Immunol. 2017;190(3):304-314. doi: 10.1111/ cei.13018. FI 3.532
15. Torres-García D, Pérez-Torres A, Manoutcharian K, Orbe U, Servín-Blanco R, Fragoso G, Sciutto E. GK-1 peptide reduces tumor growth, decreases metastatic burden, and increases survival in a murine breast cancer model. Vaccine. 2017;35(42):5653-5661. doi: 10.1016/j. vaccine.2017.08.060. FI 3.310
16. Bobes RJ, Navarrete-Perea J, Ochoa-Leyva A, Anaya VH, Hernández M, Cervantes-Torres J, Estrada K, Sánchez-Lopez F, Soberón X, Rosas G, Nunes CM, García-Varela M, Sotelo-Mundo RR, López-Zavala AA, Gevorkian G, Acero G, Laclette JP, Fragoso G, Sciutto E. Experimental and Theoretical Approaches to Investigate the Immunogenicity of Taenia solium-Derived KE7 Antigen. Infect Immun. 2017; 85(12). pii: e00395-17. doi: 10.1128/IAI.00395-17. FI 2.970
17. Navarrete-Perea J, Isasa M, Paulo JA, Corral-Corral R, Flores-Bautista J, Hernández-Téllez B, Bobes RJ, Fragoso G, Sciutto E, Soberón X, Gygi SP, Laclette JP. Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs. PLoS Negl Trop Dis. 2017; 11(9): e0005962. doi: 10.1371/journal.pntd.0005962. FI 3.885
18. Adalid-Peralta L, Rosas G, Arce-Sillas A, Bobes RJ, Cárdenas G, Hernández M, Trejo C, Meneses G, Hernández B, Estrada K, Fleury A, Laclette JP, Larralde C, Sciutto E, Fragoso G. Effect of Transforming Growth Factor-β upon Taenia solium and Taenia crassiceps Cysticerci. Sci Rep. 2017; 7(1):12345. doi: 10.1038/s41598-017-12202-z. FI 3.998
19. Rosales-Mendoza S, Monreal-Escalante E, González-Ortega O, Hernández M, Fragoso G, Garate T, Sciutto E. Transplastomic plants yield a multicomponent vaccine against cysticercosis. J Biotechnol. 2017; 266:124-132. doi: 10.1016/ j.jbiotec.2017.12.012. FI 3.503.
20. Fleury A, Alaez C, Dessein A, Rosetti M, Saenz B, Hernández M, Bobes RJ, Ramírez-Aquino R, Sciutto E, C, Gorodezky, Fragoso G. No association of IL2, IL4, IL6, TNF, and IFNG gene polymorphisms was found with Taenia solium human infection or neurocysticercosis severity in a family-based study. Hum Immunol. 2018; 79 (7): 578-582. doi: 10.1016/j.humimm.2018.04.011. FI 2.412
21. Núñez G, Villalobos N, Herrera CP, Navarrete-Perea J, Méndez A, Martinez-Maya JJ, Bobes RJ, Fragoso G, Sciutto E, Aguilar L, Del Arenal IP. Anti-GK1 antibodies damage Taenia crassiceps cysticerci through complement activation. Parasitol Res. 2018; Jun 6. doi: 10.1007/s00436-018-5943-2. FI 2.260
22. Morales J, Martínez JJ, Villalobos N, Hernandez M, Ramírez R, B Salgado Estrada, Jiménez H, A, Sánchez LM, Lazcano E, Fleury A, S de Aluja A, Sciutto E. Persistent Taenia solium cysticercosis in the state of Morelos, Mexico: Human and porcine seroprevalence. J Parasitol. 2018 Jul 18. doi: 10.1645/18-2. FI 3.288
23. Sánchez-Hernández L, Montero L, Mojica-Espinosa R, Reyes-Grajeda JP, Cervantes-Torres J, Parkhouse RM, Fragoso G, Sciutto E. Impact of the GK-1 adjuvant on peritoneal macrophages gene expression and phagocytosis. Immunol Lett. 2018 Sep;201:20-30. doi: 10.1016/j.imlet.2018.10.010. Epub 2018 Nov 14.
24. Arce-Sillas A, Cárdenas G, Álvarez-Luquín D, Hernandez M, Del Rey A, Besedovsky H, Gómez-Fuentes S G, Fragoso, Fleury A, Sciutto E, Adalid-Peralta L. Treatment-Resistant Human Extraparenchymal Neurocysticercosis: An Immune-Inflammatory Approach to Cysticidal Treatment Outcome. Neuroimmuno-modulation. 2018 Jul 24:1-7. doi: 10.1159/000491394 FI 1.685
25. Meneses G, Rosetti M, Espinosa A, Florentino A, Bautista M, Díaz G, Olvera G, Bárcena B, Fleury A, Adalid-Peralta L, Lamoyi E, Fragoso G, Sciutto E. Recovery from an acute systemic and central LPS-inflammation challenge is affected by mouse sex and genetic background. PLoS One. 2018; 13(8): e0201375. doi: 10.1371/journal.pone.0201375. FI 2.942
26. Martínez-Bautista NR, Sciutto-Conde E, Cervantes-Torres J, Segura-Velázquez R, Mercado García MC, Ramírez-Mendoza H, Trujillo Ortega ME, Delgadillo Alvarez J, Castillo-Juárez H, Sanchez-Betancourt JI. Phylogenetic analysis of ORF5 and ORF7 of porcine reproductive and respiratory syndrome (PRRS) virus and the frequency of wild-type PRRS virus in México. Transbound Emerg Dis. 2018 Aug;65(4):993-1008. doi: 10.1111/tbed.12831. Epub 2018 MarPMID:29504285 FI 4.188
27. Toledo A, Osorio R, Matus C, Martinez Lopez Y, Ramirez Cruz N, Sciutto E, Fragoso G, Arauz A, Carrillo-Mezo R, Fleury A. Human Extraparenchymal Neurocysticercosis: The Control of Inflammation Favors the Host…but Also the Parasite. Front Immunol. 2018 Nov 16;9:2652.. FI 5.085
28. Herrera-Aco DR, Medina-Campos ON, Pedraza-Chaverri J, Sciutto-Conde E, Rosas-Salgado G, Fragoso-González G. Alpha-mangostin: Anti-inflammatory and antioxidant effects on established collagen-induced arthritis in DBA/1J mice. Food Chem Toxicol. 2019 Feb;124: 300-315. doi: 0.1016/j.fct.2018.12.018. Epub 2018 Dec 14. PMID: 30557668. FI 4.679
29. Garfias S, Tamaya Domínguez B, Toledo Rojas A, Arroyo M, Rodríguez U, Boll C, Sosa AL, Sciutto E, Adalid-Peralta L, Martinez López Y, Fragoso G, Fleury A. Peripheral blood lymphocyte phenotypes in Alzheimer and Parkinson's diseases. Neurologia. 2019 Mar 11. pii: S0213-4853(19)30013-1. doi: 10.1016/.nrl.2018.10.004. [Epub ahead of print] English, Spanish. PMID: 30871733. FI 2.283
30. Cervantes-Torres J, Gracia-Mora I, Segura-Velazquez R, Montero-Montoya R, Espinosa-Aguirre J, E Gonsebatt M, Camacho-Carranza R, Rivera-Huerta M, Sanchez-Bartez F, Tinoco-Méndez M, Ostrosky-Wegman P, Fragoso G, Sciutto E. Preclinical evidences of safety of a new synthetic adjuvant to formulate with the influenza human vaccine: absence of subchronic toxicity and mutagenicity. Immunopharmacol Immunotoxicol. 2019 Feb 4:1-10. doi: 10.1080/ 08923973.2019.1566359. [Epub ahead of print] PMID: 30714433. FI 2.38
31. Meneses G, Cárdenas G, Espinosa A, Rassy D, Pérez-Osorio IN, Bárcena B, Fleury A, Besedovsky H, Fragoso G, Sciutto E. Sepsis: developing new alternatives to reduce neuroinflammation and attenuate brain injury. Ann N Y Acad Sci. 2019 Feb;1437(1):43-56. FI 4.728.
Portada en la revista ANNALS of the New York Academy of Sciences, Vol. 1437, 2019.

32. Arce-Sillas A, Sevilla-Reyes E, Álvarez-Luquín DD, Guevara-Salinas A, Boll MC, Pérez-Correa CA, Vivas-Almazan AV, Rodríguez-Ortiz U, Castellanos Barba C, Hernandez M, Fragoso G, Sciutto E, Cárdenas G, Adalid-Peralta LV. Expression of Dopamine Receptors in Immune Regulatory Cells. Neuroimmunomodulation. 2019;26(3):159-166. doi: 10.1159/000501187. Epub 2019 Jul 16, PMID: 31311029. FI 1.685
33. Rodríguez-Rodríguez N, Madera-Salcedo IK, Bugarin-Estrada E, Sánchez-Miranda E, Torres-García D, Cervantes-Torres J, Fragoso G, Rosetti F, Crispín JC, Sciutto E. The helminth-derived peptide GK-1 induces an anti-tumoral CD8 T cell response associated with downregulation of the PD-1/PD-L1 pathway. Clin Immunol. 2020 Mar; 212:108240. doi: 10.1016/j.clim.2019.07.006. Epub 2019 Jul 9. PMID: 31299381. FI 3.368
34. Villegas M, Sciutto E, Rosetti M, Fleury A, Fragoso G. Association of TRAF1/C5 Locus Polymorphisms with Epilepsy and Clinical Traits in Mexican Patients with Neurocysticercosis. Infect Immun. 2019 Nov 18; 87(12):e00347-19. doi: 10.1128/IAI.00347-19. PMID: 31570557; PMCID: PMC6867841. FI 3.201
35. Álvarez-Luquín DD, Arce-Sillas A, Leyva-Hernández J, Sevilla-Reyes E, Boll MC, Montes-Moratilla E, Vivas-Almazán V, Pérez-Correa C, Rodríguez-Ortiz U, Espinoza-Cárdenas R, Fragoso G, Sciutto E, Adalid-Peralta L. Regulatory impairment in untreated Parkinson's disease is not restricted to Tregs: other regulatory populations are also involved. Neuroinflammation. 2019 Nov 11;16(1):212. doi: 10.1186/s12974-019-1606-1. FI 5.700
36. Hernández M, Astudillo OG, Diego G, de-la-Rosa-Arana JL, Meza-Lucas A, García-Rodea R, Romo ML, Toledo A, Parkhouse RM, Garate T, Sciutto E, Fleury A. Immunodiagnosis of human neurocysticercosis: comparative performance of serum diagnostic tests in Mexico. Parasitol Res. 2019 Oct;118(10):2891-2899. doi: 10.1007/s00436-019-06425-4. Epub 2019 Aug. FI 2.260
37. RassyD, Barcena B, Perez-Osorio IN, Espinosa A, Peon AN, Terrazas LI, Meneses G, Besedovsky HO, Fragoso G, and Sciutto E. Intranasal Methylprednisolone Effectively Reduces Neuroinflammation in Mice with Experimental Autoimmune Encephalitis. J Neuropathol Exp Neurol Vol. 0, No. 0, 2020, pp. 1–12 doi: 10.1093/jnen/nlz128. FI 3.714
38. Romo, ML; Hernandez, M; Astudillo, OG; Diego, G; De-la-Rosa-Arana, JL; Meza-Lucas, A; Garcia-Rodea, R; Toledo, A; Parkhouse, RME; Garate, T; Sciutto, E; Fleury, A, Diagnostic value of glycoprotein band patterns of three serologic enzyme-linked immunoelectrotransfer blot assays for neurocysticercosis, Parasitology Research, 119(8):2521-2529, 10.1007/s00436-020-06750-z, 2020, Internacional. FI 1.641.
39. Parkhouse RME, Sciutto E, Hernández M, Cortez MM, Carpio A, Fleury A. Extraparenchymal human neurocysticercosis induces autoantibodies against brain tubulin and MOG35-55 in cerebral spinal fluid. J Neuroimmunol. 2020 Dec 15;349:577389. doi: 10.1016/j.jneuroim.2020.577389. Epub 2020 Sep 12. PMID: 32977250. FI 3.125.
40. Bolaños-Martínez OC, Govea-Alonso DO, Cervantes-Torres J, Hernández M, Fragoso G, Sciutto-Conde E, Rosales-Mendoza S. Expression of immunogenic poliovirus Sabin type 1 VP proteins in transgenic tobacco. J Biotechnol. 2020 Oct 10;322:10-20. doi: 10.1016/j.jbiotec.2020.07.007. Epub 2020 Jul 10. PMID: 32659239. FI 3.503
41. Montero L, Cervantes-Torres J, Sciutto E, Fragoso G, Helminth-derived GK-1 induces Myd88, dependent pro-inlammatory signaling events in bone marrow-derived antigen-presenting cells. Molecular Immunology. 128: 22-32, 2020. 10.1016/j.molimm.2020.09.015. FI 3.641.
42. Espinosa-Cárdenas R, Arce-Sillas A, Alvarez-Saavedra D, Catheine Boll M, García-García E, Angeles-Perea S, Fragoso G, Sciutto E, Adalid-Peralta L. Immunomodulatory effect and clinical outcome in Parkinson’s disease patients on levodopa-pramipexole combo therapy: a two-year prospective study. Journal of Neuroimmunology, 10.1016/j.jneuroim.2020.577328 347: ppm00-00, 2020. ….FI 2.880
43. Espinosa A, Meneses G, Chavarría A, Mancilla R, Pedraza-Chaverri J, Fleury A, Barcena B, Pérez-Osorio IN, Besedovsky H, Arauz A, Fragoso G, Sciutto E. Intranasal dexamethasone reduces mortality and brain damage in a mouse experimental ischemic stroke model. Neurotherapeutics. 2020 Jul 6. doi: 10.1007/s13311-020-00884-9. FI 6.035
44. Fragoso G, Sciutto E. GK1: An Alternative Treatment to Control the Respiratory Complications During COVID19. Arch Med Res. 2021 Apr;52(3):354-355. doi: 10.1016/j.arcmed.2020.10.019. Epub 2020 Nov 2. PMID: 33168195; PMCID: PMC7605854. FI: 2.09
45. Choreño-Parra JA, Jiménez-Álvarez LA, Cruz-Lagunas A, Rodríguez-Reyna TS, Ramírez-Martínez G, Sandoval-Vega M, Hernández-García DL, Choreño-Parra EM, Balderas-Martínez YI, Martinez-Sánchez ME, Márquez-García E, Sciutto E, Moreno-Rodríguez J, Barreto-Rodríguez JO, Vázquez-Rojas H, Centeno-Sáenz GI, Alvarado-Peña N, Salinas-Lara C, Sánchez-Garibay C, Galeana-Cadena D, Hernández G, Mendoza-Milla C, Domínguez A, Granados J, Mena-Hernández L, Pérez-Buenfil LÁ, Domínguez-Cheritt G, Cabello-Gutiérrez C, Luna-Rivero C, Salas-Hernández J, Santillán-Doherty P, Regalado J, Hernández-Martínez A, Orozco L, Ávila-Moreno F, García-Latorre EA, Hernández-Cárdenas CM, Khader SA, Zlotnik A, Zúñiga J. "Clinical and immunological factors that distinguish COVID-19 from pandemic influenza A(H1N1)" Front Immunol. 2021 Apr 21;12:593595. doi: 10.3389/fimmu.2021.593595. eCollection 2021. PMID: 33995342. FI 5.08
46. Adalid-Peralta L, Lopez-Roblero A, Camacho-Vázquez C, Nájera-Ocampo M, Guevara-Salinas A, Ruiz-Monroy N, Melo-Salas M, Morales-Ruiz V, López-Recinos D, Ortiz-Hernández E, Demengeot J, Vazquez-Perez JA, Arce-Sillas A, Gomez-Fuentes S, Parkhouse RME, Fragoso G, Sciutto E, Sevilla-Reyes EE. Regulatory T Cells as an Escape Mechanism to the Immune Response in Taenia crassiceps Infection. Frontiers in Cellular and Infection Microbiology April 2021, Volume 11 Article 630583 doi: 10.3389/fcimb.2021.630583. FI: 4.3
47. Cárdenas G, Torres-García D, Cervantes-Torres J, Rosales-Mendoza S, Fleury A, Fragoso G, Laclette JP, Sciutto E. Role of Systemic and Nasal Glucocorticoid Treatment in the Regulation of the Inflammatory Response in Patients with SARS-Cov-2 Infection. Arch Med Res. 2021 Feb;52(2):143-150. doi: 10.1016/j.arcmed.2020.10.014. Epub 2020 Oct 26. PMID: 33160751; PMCID: PMC7586926. FI:2.2
48. Gomez-Fuentes, Hernández-de la Fuente S, Morales-Ruiz V, López-Recinos D, Guevara-Salinas A, Parada-Colin MC, Espitia C, Ochoa-Leyva A, Sánchez F, Villalobos N, Arce-Sillas A, Hernández M, Mora SI, Fragoso G, Sciutto E, Adalid-Peralta L. A novel, sequencing-free strategy for the functional characterization of Taenia solium proteomic fingerprint. PLoS Negl Trop Dis. 2021 Feb 18;15(2):e0009104. doi: 10.1371/journal.pntd.0009104. PMID: 33600419; PMCID: PMC7924735. FI: 3.88
49. Hamamoto Filho PT, Fragoso G, Sciutto E, Fleury A. Inflammation in neurocysticercosis: clinical relevance and impact on treatment decisions. Expert Rev Anti Infect Ther. 2021 Apr 9:1-16. doi: 10.1080/14787210.2021.1912592. Epub ahead of print. PMID: 33794119. FI: 4.04
50. Voutssas-Lara J, Cervantes-Torres J, Hernández M, Bobes RJ, Lamoyi E, Vázquez-Ramírez RA, Mendoza L, Reyes-Barrera KL, López-Martínez R, Alpuche-Solís ÁG, Rosales-Mendoza S, Huerta L, Fragoso G, Sciutto E. Influence of adjuvants on the amount, specificity and functional activity of antibody response to human influenza vaccine in mice. Mol Immunol. 2021 Jul;135:398-407. doi: 10.1016/j.molimm.2021.05.003. Epub 2021 May 20. PMID: 34022515. FI: 3.64
51. *Toledo A, Orozco-Suárez S, Rosetti M, Maldonado L, Bautista SI, Flores X, Arellano A, Moreno S, Alonso M, Martínez-Juárez IE, Fragoso G, Sciutto E, Fleury A. Temporal lobe epilepsy: Evaluation of central and systemic immune-inflammatory features associated with drug resistance. Seizure. 2021 Jul 26;91:447-455. doi: 10.1016/j.seizure.2021.07.028. Epub ahead of print. PMID: 34340190. FI: 3.1
52. Pérez-Osorio IN, Espinosa A, Giraldo Velázquez M, Padilla P, Bárcena B, Fragoso G, Jung-Cook H, Besedovsky H, Meneses G, Sciutto Conde EL. Nose-to-Brain Delivery of Dexamethasone: Biodistribution Studies in Mice. J Pharmacol Exp Ther. 2021 Sep;378(3):244-250. doi: 10.1124/jpet.121.000530. Epub 2021 Jun 16. PMID: 34531307. FI: 3.389.
53. Cárdenas G, Fragoso G, Sciutto E. Neuroinflammation in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection: Pathogenesis and clinical manifestations. Curr Opin Pharmacol. 2021 Dec 31;63:102181. doi: 10.1016/j.coph.2021.12.008. Epub ahead of print. PMID: 35074661; PMCID: PMC8782621. FI 5.47.

54. Manuel Giraldo Velázquez, Iván Nicolás Pérez-Osorio, Alejandro Espinosa-Cerón, Brandon Bárcena, A. Calderón-Gallegos, Gladis Fragoso, Mónica Torres, Nayeli Paez-Martínez, Edda Lydia Sciutto. Intranasal methylprednisolone ameliorate neuroinflammation induced bychronic toluene exposure. Pharmaceutics 2022, 13, x. https://doi.org/10.3390/. FI 6.321.

55. Graciela Cárdenas, María Chávez-Canales, Ana María Espinosa, Antonio Jordán-Ríos, Daniel Anica Malagon, Manlio Fabio Márquez Murillo, Laura Victoria Torres Araujo, Ricardo Leopoldo Barajas Campos,Rosa María Wong-Chew, Luis Esteban Ramirez González, Karent Ibet Cresencio, Enrique Garía Velázquez, Mariana Rodriguez de la Cerda, Yoana Leyva, Joselin Hernández-Ruiz, María Luisa Hernández-Medel, Mireya León-Hernández, Karen Medina Quero, Anahí Sánchez Monciváis, Sergio Hernández Díaz, Ignacia Rosalia Zeron Martínez, Adriana Martínez-Cuazitl, Iván Noé Martínez Salazar, Eduardo Beltrán Sarmiento, Aldo Figueroa Peña, Patricia Saraí Hernández Hernández, Rafel Ignacio Aguilar Reynoso, Daniela Murillo Reyes, Luis Rodrigo del Río Ambriz, Rogelio Antonio Alfaro Bonilla, Jocelyn Cruz, Leonor Huerta, Nora Alma Fierro, Marisela Hernández, Mayra Pérez-Tapia, Gabriela Meneses, Erick Espíndola-Arriaga, Gabriela Rosas, Alberto Chinney, Sergio Rosales Mendoza, Juan Alberto Hernández-Aceves Jaquelynne Cervantes-Torres, Anai Fuentes Rodríguez, Roxana Olguin Alor, Sandra Ortega Francisco, Evelyn Alvarez Salazar, Hugo Besedovsky, Marta C. Romano, Raúl J. Bobes, Helgi Jung, Gloria Soldevila, Juan López-Alvarenga, Gladis Fragoso, Juan Pedro Laclette, Edda Sciutto. Intranasal dexamethasone: a new clinical trial for the control of inflammation and neuroinflammation in COVID-19 patients. Trials. 2022 Feb 14;23(1):148. doi: 10.1186/s13063-022-06075-5. PMID: 35164840; PMCID: PMC8845269. FI 2.049

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

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mdcbq@posgrado.unam.mx