1. Vanessa Ramírez-Delgado, Luis Felipe Hernández-Ayala, Juan Carlos García-Ramos, Marcos Flores-Alamo, Rodrigo Galindo-Murillo, Lena Ruiz-Azuara* and Luis Ortiz-Frade *. "Versatile nitrato coordination modes in Ni(II) complexes with the ligand 1,8-bis-(2-pyridyl)-3,6-dithiaoctane: Structural, spectroscopic, electrochemical and theoretical studies" Eur. J. Inorg. Chem. (2015) , 3307–3316 INDICE DE IMPACTO 2.941

2. Rodrigo Galindo-Murillo, Juan Carlos García-Ramos, Lena Ruiz-Azuara, Thomas E. Cheatham III and Fernando Cortés-Guzmán, Intercalation processes of copper complexes in DNA. Nucleic Acids Research (2015) Vol. 43, No. 11, 5364-5376 INDICE DE IMPACTO 7.479

3. Yanis Toledano-Magaña, Juan Carlos García-Ramos, Marcos Flores-Alamo, Mayra Manzanera-Estrada, Marisol Navarro-Olivarria, Luis Ortiz-Frade, Rodrigo Galindo-Murillo, Lena Ruiz-Azuara, Blanca Cabrera-Vivas, Potential amoebicidal activity of hydrazone derivatives: Synthesis, characterization, electrochemical behavior, theoretical study and evaluation of the biological activity.Molecules (2015), 20, 9929-9948; doi:10.3390/molecules20069929 INDICE DE IMPACTO 1.738

4. Toledano-Magana, Yanis; Melendrez-Luevano, Ruth; Navarro-Olivarria, Marisol; Garcia-Ramos, Juan Carlos; Flores-Alamo, Marcos; Ortiz-Frade, Luis; Ruiz-Azuara, Lena; Cabrera-Vivas, Blanca. Synthesis, characterization and evaluation of the substituent effect on the amoebicide activity of new hydrazone derivatives M. Med. Chem. Comm. (2015) V5 N7 p. 989-996. INDICE DE IMPACTO

5. Juan Carlos García-Ramos, Rodrigo Galindo-Murillo, Araceli Tovar-Tovar, Ana Luisa Alonso-Saenz, Virginia Gómez-Vidales, Marcos Flores-Alamo, Luis Ortiz-Frade, Fernando Cortes-Guzmán, Rafael Moreno-Esparza,Antonio Campero, and Lena Ruiz-Azuara. The p-Back-Bonding Modulation and Its Impact in the Electronic Properties of CuII Antineoplastic Compounds: An Experimental and Theoretical Study. Chemistry a European Journal (2014), v20 n42,13730-13741. INDICE DE IMPACTO

6. Lorena Becco, Juan Carlos García-Ramos, Lena Ruiz Azuara, Dinorah Gambino, Beatriz Garat. Analysis of the DNA Interaction of Copper Compounds Belonging to the Casiopeínas ® Antitumoral Series. Biol Trace Elem Res (2014) 161:210-215 DOI 10.1007/s 12011-014-0098-1 v161 n2 p210-215 INDICE DE IMPACTO 1.127

7. Sarniguet, Cynthia; Toloza, Jeannette; Cipriani, Micaella; Lapier, Michel; Vieites, Marisol; Toledano-Magana, Yanis; Garcia-Ramos, Juan Carlos; Ruiz-Azuara, Lena; Moreno, Virtudes; Diego Maya, Juan; Olea Azar, Claudio; Gambino, Dinorah; Otero, Lucia.Water-Soluble Ruthenium Complexes Bearing Activity Against Protozoan Parasites. Biological Trace Element Research (2014) V159 N1-3 p 379-392 (JUN 2014) INDICE DE IMPACTO 1.127

8. Ramirez-Delgado, Vanessa; Morales Leon, Ricardo Emmanuel; Hernandez-Ayala, Luis Felipe; Ramirez Coutino, Victor Angel; Javier Rodriguez, Francisco; Osorio-Monreal, Guadalupe; Garcia-Ramos, Juan Carlos; Flores-Alamo, Marcos; Ruiz-Azuara, Lena; Ortiz-Frade, Luis. First example of bridge mono-coordination mode for the ligand 1,8-bis-(2-pyridyl)-3,6-dithiaoctane (pdto) in a Co(II) tetrahedral complex. POLYHEDRON (2014) V74 p72-78 (MAY 28 2014) INDICE DE IMPACTO 2.207

9. Juan Carlos García-Ramos, Rodrigo Galindo-Murillo, Fernando Cortés-Guzmán and Lena Ruiz Azuara. Metal-Based Drug-DNA Interactions. J. Mex. Chem. Soc. 2013 57(3), 245-259. (Review) INDICE DE IMPACTO 0.380

10. Anllely Grizett Gutiérrez , Adriana Vázquez-Aguirre , Juan Carlos García-Ramos , Marcos Flores-Alamo ,Enrique Hernández-Lemus , Lena Ruiz-Azuara , Carmen Mejía. Copper(II) mixed chelate compounds induce apoptosis through reactive oxygen species in neuroblastoma cell line CHP-212. Journal of Inorganic Biochemistry 126 (2013) 17–25 INDICE DE IMPACTO 3.252

11. Cañas-Alonso, Roberto Carlos; Fuentes-Noriega, Ines; Ruiz-Azuara, Lena. Blood to Plasma Ratio, Short-Term Stability and Plasma Protein Binding of Casiopeina IIgly, a Copper (II) Based Compound with Antineoplastic Activity. Journal of the Mexican Chemical Society (2013)V57-3, 239-244. JUL-SEP 2013 INDICE DE IMPACTO 0.382

12. Alejandra Idan Valencia-Cruz, Laura I. Uribe-Figueroa, Rodrigo Galindo-Murillo, Karol Baca-López, Anllely G. Gutiérrez, Adriana Vázquez-Aguirre, Lena Ruiz-Azuara, Enrique Hernández-Lemus, Carmen Mejía. “Whole genome gene expression analysis reveals casiopeína-induced apoptosis pathways. Plos One (2013) 8(1), e54664. (18 p). INDICE DE IMPACTO 4.351

13. M. Flores-Alamo, B. M. Cabrera-Vivas, R. Meléndez-Luevano, J.M. Hernández P. and L. Ruiz-Azuara. 1-{(E)-[5-(2-Nitrophenyl) furan-2-yl]methylidene}-2,2-diphenylhydrazine. Acta Crystllographyca Section E (2013) 69, 90 INDICE DE IMPACTO 0.411

14. Y. Toledano-Magaña, J. C. García-Ramos, C. García-Manrique, M. Flores-Alamo and L. Ruiz-Azuara. Tris(5,6-dimethyl-1.10-phenanthroline-n2N,N)copper(II) bis(hexafluoridophosphate) acetonitrile monosolvate. Acta Crystallographica Section E (2012) 68, m987-m988. INDICE DE IMPACTO 0.411

15. Guadalupe Vértiz, Luis Enrique García-Ortuño, Juan Pablo Bernal, María Elena Bravo-Gómez, Elena Lounejeva, Amada Huerta and Lena Ruiz-Azuara. Pharmacokinetics and hematotoxicity of a novel copper-baser anticancer agent: Casiopeína III-Ea, after a single intravenous dose in rats. Fundamental & Clinical Pharmacology. 07/08/2012. (doi: 10.1111/j.1472-8206.2012.01075.x) V28 N1 p 78-87 INDICE DE IMPACTO 2.372

16. Galindo –Murillo, Rodrigo; Ruiz, Lena; Moreno-Esparza, Rafael; Cortes-Guzman, Fernando. “Molecular recognition between DNA and copper-based anticancer complexes”. Physical Chemistry Chemical Physics (2012) 14, 15539-15546.INDICE DE IMPACTO 4.116

17. Cristina Trejo-Solís, Dolores Jimenez-Farfan, Sara Rodriguez-Enriquez, Francisca Fernandez-Valverde, Arturo Cruz-Salgado, Lena Ruiz-Azuara and Julio Sotelo. Copper compound induces autophagy and apoptosis of glioma cells by reactive oxygen species and jnk activation, BMC Cancer (2012), 12,156. doi:10.1186/1471-2407-12-156. INDICE DE IMPACTO 2.736

18. Alvaro Marín-Hernández, Juan Carlos Gallardo-Pérez, Sayra Y. López-Ramírez, Jorge Donato García-García, José Salud Rodríguez-Zavala, Lena Ruiz-Ramírez, Sabel Gracia-Mora, Alejandro Zentella-Dehesa, Marcela Sosa-Garrocho, Marina Macías-Silva, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez. Casiopeína II-gly and bromo-pyruvate inhibition of tumor hexokinase, glycolysis, and oxidative phosphorylation. Archives of Toxicology (2012) 86, 753-763. INDICE DE IMPACTO 1.909

19. Lorena Becco, Alejandra Rodríguez, María Elena Bravo, Ma. José Prieto, Lena Ruiz Azuara, Beatriz Garat, Virtudes Moreno, Dinorah Gambino. New achievements on biological aspects of copper complexes Casiopeínas ®; interaction with DNA and proteins and anti-Trypanosoma cruzi activity. Journal of Inorganic Biochemistry. (2012), 109, 49-56. INDICE DE IMPACTO 3.252

20. Manzanera-Estrada, M.; Flores-Alamo, M.; Grevy M,J.-M.; Ruiz-Azuara,L.; Ortiz-Frade, L. Aqua [1,8-bis(pyridin-2-yl)-3,6-dithiaoctane-K4N,S,S’,N’]copper(II) dinitrate acetonitrile monosolvate. Acta Crystallographica Section E. (2012), 68, m135-m136.INDICE DE IMPACTO 0.411

21. García-Ramos, Juan Carlos; Toledo-Magaña, Yanis; Talavera-Contreras, Luis Gabriel; Flores-Alamo, Marcos; Ramírez-Delgaado, Vanessa; Morales-León, Emmanuel; Ortiz-Frade, Luis Antonio; Vázquez-Aguirre, Adriana; Gutiérrez, Anllely; Mejía, Carmen; Carrero, Julio Cesar; Laclette San Román, Juan Pedro; Ruiz-Azuara, Lena. Potential antitumor and amoebicide activity of first row transition metals compounds with 2, 9-Bis-(2’, 5’-diazahexanyl)-1. 10-phenanthroline (L1). Dalton Transactions (2012) 31(34), 10164-10174 INDICE DE IMPACTO 4.081

22. María Elena Bravo-Gómez, Silvia Dávila-Manzanilla, Jessica Flood-Garibay, Miguel Ángel Muciño-Hernández, Angel Mendoza, Juan Carlos García-Ramos, Rafael Moreno-Esparza, Lena Ruiz-Azuara. Secondary ligand effects on the cytotoxicity of several Casiopeína’s group II compounds. Journal of the Mexican Chemical Society. (2012), 56(1), 85-92. INDICE DE IMPACTO 0.380

23. Araceli Tovar-Tovar, Juan-Carlos García-Ramos, Marcos Flores-Alamo* and Lena Ruiz-Azuara Aqua(1,10-phenanthroline-κ-N,N’)(valinate-κ-N,O)Cu(II) nitrate dehydrate. Acta Crystallographica Section E (2011) 67, m1796-m1797 INDICE DE IMPACTO 0.411

24. Juan Carlos García-Ramos, Araceli Tovar-Tovar, Joseelyne Hernández-Lima, Fernando Cortés-Guzmán, Rafael Moreno-Esparza, Lena Ruiz-Azuara. A new kind of intermolecular stacking interaction between copper (II) mixed chelate complex (Casiopeína III-ia) and adenine. Polyhedron (2011) 30, 2697-2703. INDICE DE IMPACTO 2.207

25. Rodrigo Galindo-Murillo, Josselyne Hernandez-Lima, Mayra González-Rendón, Fernando Cortés-Guzmán, Lena Ruiz-Azuara and Rafael Moreno-Esparza. Stacking between Casiopeinas ® and DNA bases. Physical Chemistry Chemical Physics (2011), 13, 14510-14515. INDICE DE IMPACTO 4.116

26. J. Serment-Guerrero, P. Cano-Sanchez, E. Reyes-Perez, F. Velazquez-Garcia, M.E. Bravo-Gomez and L. Ruiz-Azuara. Genotoxicity of the copper antineoplastic coordination complexes casiopeinas®. Toxicology in vitro. (2011), 25(7), 1376-1384. INDICE DE IMPACTO 2.060

27. Angélica López-Rodríguez, Alfonso Carabez-Trejo, Fernando Rosas-Sánchez, Carmen Mejía, Lena Ruiz-Azuara, Ricardo Miledi, Ataúlfo Martínez-Torres. The metal-coordinated Casiopeína IIIEa induces the petite-like phenotype in Saccharomyces cerevisiar. BioMetals. (2011), 24, 1189-1196. INDICE DE IMPACTO 3.172

28. Radamés Alemón-Medina, María Elena Bravo-Gómez, María Isabel Gracia-Mora, Lena Ruiz-Azuara. Comparison between the antiproliferative effect and intracelular glutathione depletion induced by Casiopeína IIgly and cisplatin in murine melanoma B16 cells. Toxicology in Vitro (2011), 25(4), 868-873. INDICE DE IMPACTO 2.060

29. J.E. Miranda-Calderon, L. Medina-Torres, M. Tinoco-Mendez, R. Moreno-Esparza, L. Ruiz-Ramirez.Characterization of physical interaction between Casiopeina III-ia and chitosan. Toward a Cas III-ia drug delivery system. Carbohydrate Research (2011), 346(1), 121-126 INDICE DE IMPACTO 2.025

30. Lena Ruiz Azuara and Ma Elena Bravo, Copper Compounds in Cancer Chemotherapy, Current Medicinal Chemistry (2010), 17(31), 3606-3615, 31/12/10. INDICE DE IMPACTO 4.708

31. Cañas-Alonso Roberto C., Fuentes-Noriega Inés and Ruiz-Azuara Lena. Pharmacokinetics of Ca siopeína IIgly in beagle dog: A copper based compound with antineoplastic activity. Journal of Bioanalysis & Biomedicine (2010), 2(1), 228-34. INDICE DE IMPACTO

32. Remy Kachadourian, Heather M. Brechbuhl, Lena Ruiz-Azuara, Isabel Gracia-Mora and Brian J. Day, Casiopeína IIgly-induced oxidative stress and mitochondrial dysfunction in human lung cancer A549 and H157 cells. Toxicology (2010), 268, 176–183 INDICE DE IMPACTO 0.816

33. Luis Ortiz Frade, Rene Antaño, Juan Manriquez, Ignacio González, Lena Ruiz Azuara and Rafael Moreno Esparza. Chronoamperometric study and x-ray analysis of Ru(II)-pdto (1,8-bis-(2-pyridyl)-3,6-dithiaoctane) complexes with substituted 1,10-phenanthrolines. Polyhedron (2010), 29(6), 328-332. INDICE DE IMPACTO 2.207

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx