Contacto
Campos de conocimiento
Biotecnología
Farmacología
Reconocimiento Molecular y Bioestructura
Líneas de investigación
1.- Desarrollo de biosensores fluorescentes utilizando el sistema calmodulina.
2.- Estudios básicos de las interacciones del sistema Calmodulina-péptidos para el desarrollo de nuevos biofármacos.
3.- Estudios teóricos de las interacciones proteína-péptido utilizando dinámica molecular.
4.- Estudio teórico-pactico de las interacciones proteína-fármaco.
5.- Desarrollo de nuevos biosensores para la identificación y desarrollo de fármacos antidiabéticos utilizando la proteína alfa-glucosidasa.
Publicaciones
Andrea Coronell-Tovar,a Francisco Cortés-Benítez,b and Martin González-Andrade. The importance of including the C-terminal domain of PTP1B1-400 to identify potential antidiabetic inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 38:1, DOI: 10.1080/14756366.2023.2170369
Matuz-Mares, D.; González-Andrade, M.; Araiza-Villanueva, M.G.; Vilchis-Landeros, M.M.; Vázquez-Meza, H. Mitochondrial Calcium: Effects of Its Imbalance in Disease. Antioxidants 2022, 11, 801. https://doi.org/10.3390/antiox11050801
Ramírez-Silva L, Hernández-Alcántara G, Guerrero-Mendiola C, González-Andrade M, Rodríguez-Romero A, Rodríguez-Hernández A, Lugo-Munguía A, Gómez-Coronado PA, Rodríguez-Méndez C, Vega-Segura A. The K+-Dependent and -Independent Pyruvate Kinases Acquire the ActiveConformation by Different Mechanisms. Int J Mol Sci. 2022 Jan doi: 103390ijms23031347
Vasquez-Bochm L.X., Velazquez-Lopez I., Mata R., Sosa-Peinado A., Cano-Sanchez P., Gonzalez-Andrade M., Application of a fluorescent biosensor in determining the binding of 5-ht to calmodulin. Chemosensors 2021 09
Rebollar-Ramos D, Ovalle-Magallanes B, Palacios-Espinosa JF,Macías-Rubalcava ML, Raja HA, González-Andrade M, Mata R.α-Glucosidase and PTP-1B Inhibitors from Malbranchea dendritica.ACS Omega. 2021 Aug 25635:2296922981 doi: 101021acsomega.103708eCollection 2021 Sep 7
De-la-Cruz-Martínez, L.; Duran-Becerra, C.; González-Andrade, M.; Páez-Franco, J.C.; Germán-Acacio, J.M.; Espinosa-Chávez, J.; Torres-Valencia, J.M.; Pérez-Villanueva, J.; Palacios-Espinosa, J.F.; Soria-Arteche, O.; Cortés-Benítez, F. Indole- and Pyrazole-Glycyrrhetinic Acid Derivatives as PTP1B Inhibitors: Synthesis, In Vitro and In Silico Studies. Molecules 2021, 26, 4375. https://doi.org/10.3390/molecules26144375
Díaz-Rojas M, Raja H, González-Andrade M, Rivera-Chávez J,Rangel-Grimaldo M, Rivero-Cruz I, Mata R.Protein tyrosine phosphatase 1B inhibitors from the fungus Malbranchea albolutea.Phytochemistry. 2021 Apr;184112664 doi: 101016j.phytochem.2021 112664 Epub2021 Jan 29
Turrubiartes-Martínez E, Bodega-Mayor I, Delgado-Wicke P, Molina-JiménezF, Casique-Aguirre D, González-Andrade M, Rapado I, Camós M,Díaz-de-Heredia C, Barragán E, Ramírez-Orellana M, Aguado B, Figuera Á, Martínez-López J, Fernández-Ruiz E.TYK2 Variants in B-Acute Lymphoblastic Leukaemia.2 Genes (Basel). 2020 Nov 281112. pii: E1434 doi: 103390genes11121434
Sosa-Peinado A, León-Cruz E, Velázquez-López I, Matuz-Mares D, Cano-Sánchez P, González-Andrade M. Theoretical-experimental studies of calmodulin-peptide interactions at different calcium equivalents. J Biomol Struct Dyn. 2020 Oct 30:1-12. doi: 10.1080/07391102.2020.1841679. Epub ahead of print. PMID: 33124950.
Salinas-Arellano E, Pérez-Vásquez A, Rivero-Cruz I, Torres-Colin R, González-Andrade M, Rangel-Grimaldo M, Mata R.Flavonoids and Terpenoids with PTP-1B Inhibitory Properties from the Infusion of Salvia amarissima Ortega.4 Molecules. 2020 Aug 12515. pii: E3530 doi: 103390molecules25153530
Jiménez-Arreola BS, Aguilar-Ramírez E, Cano-Sánchez P, Morales-JiménezJ, González-Andrade M, Medina-Franco JL, Rivera-Chávez J.Dimeric phenalenones from Talaromyces sp. (IQ-313) inhibit hPTP1B1-400: Insights into mechanistic kinetics from in vitro and in silico studies.5 Bioorg Chem. 2020 Aug;101103893 doi: 101016j.bioorg.2020 103893 Epub 2020
Rangel-Grimaldo M, Macías-Rubalcava ML, González-Andrade M, Raja H, FigueroaM, Mata R.α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors from Malbrancheacircinata.J Nat Prod. 2020 Jan 3 doi: 101021acs.jnatprod.901108 [Epub ahead of print].
Meléndez TA, Huanosta-Gutiérrez A, Barriga-Montoya C, González-Andrade M, Gómez-Lagunas F.Dronedarone blockage of the tumor-related Kv10.1 channel: a comparison withamiodarone.2 Pflugers Arch. 2020 Jan;4721:7587 doi: 101007s00424019023428 Epub 2020 Jan 2.
Guevara-Flores A, Martínez-González JJ, Herrera-Juárez ÁM, Rendón JL, González-Andrade M, Torres Durán PV, Enríquez-Habib RG, Del Arenal Mena IP. Effect of curcuminoids and curcumin derivate products on thioredoxin-glutathione reductase from Taenia crassiceps cysticerci. Evidence suggesting a curcuminoxidation product as a suitable inhibitor. PLoS One. 2019 Jul 22 147:e0220098 doi: 101371journal.pone.0220098eCollection 2019.
Flores-Bocanegra L., Torres-Colin R., Gonzalez-Andrade M., Calderon J.S., Mata R., In Vivo and In Vitro α-Glucosidase Inhibitory Activity of Perfoliatin A from Melampodium perfoliatum. Natural Product Communications 2019.
