1.- Desarrollo de biosensores fluorescentes utilizando el sistema calmodulina.
2.- Estudios básicos de las interacciones del sistema Calmodulina-péptidos para el desarrollo de nuevos biofármacos.
3.- Estudios teóricos de las interacciones proteína-péptido utilizando dinámica molecular.
4.- Estudio teórico-pactico de las interacciones proteína-fármaco.
5.- Desarrollo de nuevos biosensores para la identificación y desarrollo de fármacos antidiabéticos utilizando la proteína alfa-glucosidasa.

Publicaciones

1. Andrea Coronell-Tovar, Juan P. Pardo-Vázquez, Adela Rodríguez-Romero, Alejandro Sosa-Peinado, Luz Vasquez-Bochm, Patricia Cano-Sánchez, L.I. Álvarez-Añorve, and Martin González-Andrade. Protein Tyrosine Phosphatase 1B (PTP1B): an Update About its Function, Structure, and Inhibition Strategies to Development of Antidiabetic Drugs. FEBS Letters. 2024, 598, 1811-1838. https://doi.org/10.1002/1873-3468.14901

2. Río IM, González-Andrade M, Portillo FV and Olvera-Carranza C. Exploring the role of the residues into catalytic cavity of inulosucrase from Leuconostoc citreum CW28. (2024) Int J Biol Macromol. 135159 https://doi.org/10.1016/j.ijbiomac.2024.135159

3. Navarrete-Mondragón RDC, Cortés-Benítez F, Mendieta-Wejebe JE, González-Andrade M and Pérez-Villanueva J. Virtual and in vitro Screening Employing a Repurposing Approach Reveal 13-Cis-retinoic acid is a PTP1B Inhibitor. (2024) ChemMedChem. e202400452 https://doi.org/10.1002/cmdc.202400452

4. Mendoza-Jasso ME, Pérez-Villanueva J, Alvarado-Rodríguez JG, González-Andrade M and Cortés-Benítez F. 3-Benzylaminomethyl Lithocholic Acid Derivatives Exhibited Potent and Selective Uncompetitive Inhibitory Activity Against Protein Tyrosine Phosphatase 1B (PTP1B). (2024) ACS Omega. 9, 33224-33238 https://pubs.acs.org/doi/10.1021/acsomega.4c04948

5. Padilla-Mayne S, Ovalle-Magallanes B, Figueroa M, Linares E, Bye R, Rivero-Cruz I, González-Andrade M, Aguayo-Ortiz R and Mata R. Chemical Analysis and Antidiabetic Potential of a Decoction from Roots. (2024) J Nat Prod. 87, 501-513 https://doi.org/10.1021/acs.jnatprod.3c00711

6. José A. Gutiérrez-González, Araceli Pérez-Vásquez, Martín González-Andrade, Annia Galano, José L. Villaseñor, and Rachel Mata. Calmodulin-Targeting Molecules from Ageratina grandifolia. J. Nat. Prod. 2023, 86, 2562−2570. https://doi.org/10.1021/acs.jnatprod.3c00794

7. Miriam Díaz-Rojas, Martin González-Andrade, Rodrigo Aguayo-Ortiz, Rogelio Rodríguez-Sotres, Araceli Pérez-Vásquez, Abraham Madariaga-Mazón, Rachel Mata. Discovery of inhibitors of protein tyrosine phosphatase 1B contained in a natural products library from Mexican medicinal plants and fungi using a combination of enzymatic and in silico methods. Frontiers in Pharmacology, October 2023, https://doi.org/10.3389/fphar.2023.1281045

8. Álvarez-Almazán S, Solís-Domínguez LC, Duperou-Luna P, Fuerte-Gómez T, González-Andrade M, Aranda-Barradas ME, Palacios-Espinosa JF, Pérez-Villanueva J, Matadamas-Martínez F, Miranda-Castro SP, Mercado-Márquez C, Cortés-Benítez F. Anti-Diabetic Activity of Glycyrrhetinic Acid Derivatives FC-114 and FC-122: Scale-Up, In Silico, In Vitro, and In Vivo Studies. Int J Mol Sci. 2023 Aug 15;24(16):12812. doi: https://doi.org/10.3390/ijms241612812

9. Coronell-Tovar A, Cortés-Benítez F, González-Andrade M. The importance of including the C-terminal domain of PTP1B1-400 to identify potential antidiabetic inhibitors. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2170369. doi: https://doi.org/10.1080/14756366.2023.2170369 PMID: 36997321; PMCID: PMC10064822.

10. Trapala J, González-Andrade M, Olvera C, Cayetano M, Sanz-Aparicio J, Jimenez-Ortega E, Bustos-Jaimes I, Montiel C. Relevance of aromatic and polar amino acids in the specificity of Inulinase ISO3 from Kluyveromyces marxianus: A molecular dynamics approach with an experimental verification. Int J Biol Macromol. 2023 May 5:124734. doi: https://doi.org/10.1016/j.ijbiomac.2023.124734 Epub ahead of print. PMID: 37150366.

11. Sosa-Peinado, A.; Fructuoso-García, K.; Vásquez-Bochm, L.X.; González-Andrade, M. Bisindolylmaleimides New Ligands of CaM Protein. Molecules 2022, 27, 7161. https://doi.org/10.3390/molecules27217161

12. Araceli Pérez-Vásquez, Miriam Díaz-Rojas, Erika V.Castillejos-Ramírez, Alejandra Pérez-Esquivel, Yullet Montaño-Cruz, Isabel Rivero-Cruz, Rafael Torres-Colín, Martin González-Andrade, Rogelio Rodríguez-Sotres, José Alberto Gutiérrez-González, Abraham Madariaga-Mazón, and Rachel Mata. Protein tyrosine phosphatase 1B inhibitory activity of compounds from Justicia spicigera (Acanthaceae). Phytochemistry 2022. https://doi.org/10.1016/j.phytochem.2022.113410

13. Matuz-Mares, D.; González-Andrade, M.; Araiza-Villanueva, M.G.; Vilchis-Landeros, M.M.; Vázquez-Meza, H. Mitochondrial Calcium: Effects of Its Imbalance in Disease. Antioxidants 2022, 11, 801. https://doi.org/10.3390/antiox11050801

14. Ramírez-Silva L, Hernández-Alcántara G, Guerrero-Mendiola C, González-Andrade M, Rodríguez-Romero A, Rodríguez-Hernández A, Lugo-Munguía A, Gómez-Coronado PA, Rodríguez-Méndez C, Vega-Segura A. The K+-Dependent and -Independent Pyruvate Kinases Acquire the ActiveConformation by Different Mechanisms. Int J Mol Sci. 2022 Jan 23(3):1347 https://doi.org/10.3390/ijms23031347

15. Sosa-Peinado A, León-Cruz E, Velázquez-López I, Matuz-Mares D, Cano-Sánchez P, González-Andrade M. Theoretical-experimental studies of calmodulin-peptide interactions at different calcium equivalents. J Biomol Struct Dyn. 2022 Oct 30 40(6):2689-2700. doi: https://doi.org/10.1080/07391102.2020.1841679

16. Vásquez-Bochm, L.X.; Velázquez-López, I.; Mata, R.; Sosa-Peinado, A.; Cano-Sánchez, P.; González-Andrade, M. Application of a Fluorescent Biosensor in Determining the Binding of 5-HT to Calmodulin. Chemosensors 2021, 9, 250. https://doi.org/10.3390/chemosensors9090250

17. Rebollar-Ramos D, Ovalle-Magallanes B, Palacios-Espinosa JF, Macías-Rubalcava ML, Raja HA, González-Andrade M and Mata R. α-Glucosidase and PTP-1B Inhibitors from . (2021) ACS Omega. 6, 22969-22981 https://doi.org/10.1021/acsomega.1c03708

18. De-la-Cruz-Martínez, L.; Duran-Becerra, C.; González-Andrade, M.; Páez-Franco, J.C.; Germán-Acacio, J.M.; Espinosa-Chávez, J.; Torres-Valencia, J.M.; Pérez-Villanueva, J.; Palacios-Espinosa, J.F.; Soria-Arteche, O.; Cortés-Benítez, F. Indole- and Pyrazole-Glycyrrhetinic Acid Derivatives as PTP1B Inhibitors: Synthesis, In Vitro and In Silico Studies. Molecules 2021, 26, 4375. https://doi.org/10.3390/molecules26144375

19. Díaz-Rojas M, Raja H, González-Andrade M, Rivera-Chávez J, Rangel-Grimaldo M, Rivero-Cruz I and Mata R. Protein tyrosine phosphatase 1B inhibitors from the fungus Malbranchea albolutea. (2021) Phytochemistry. 184, 112664 https://doi.org/10.1016/j.phytochem.2021.112664

20. Turrubiartes-Martínez E, Bodega-Mayor I, Delgado-Wicke P, Molina-JiménezF, Casique-Aguirre D, González-Andrade M, Rapado I, Camós M,Díaz-de-Heredia C, Barragán E, Ramírez-Orellana M, Aguado B, Figuera Á, Martínez-López J, Fernández-Ruiz E.TYK2 Variants in B-Acute Lymphoblastic Leukaemia.2 Genes (Basel). 2020 Nov 2811(12). pii: E1434 https://doi.org/10.3390/genes11121434

21. Salinas-Arellano E, Pérez-Vásquez A, Rivero-Cruz I, Torres-Colin R, González-Andrade M, Rangel-Grimaldo M, Mata R.Flavonoids and Terpenoids with PTP-1B Inhibitory Properties from the Infusion of Salvia amarissima Ortega.4 Molecules. 2020 Aug 1 25(15). https://doi.org/10.3390/molecules25153530

22. Jiménez-Arreola BS, Aguilar-Ramírez E, Cano-Sánchez P, Morales-JiménezJ, González-Andrade M, Medina-Franco JL, Rivera-Chávez J.Dimeric phenalenones from Talaromyces sp. (IQ-313) inhibit hPTP1B1-400: Insights into mechanistic kinetics from in vitro and in silico studies.5 Bioorg Chem. 2020 Aug;101103893 https://doi.org/10.1016/j.bioorg.2020.103893

23. Rangel-Grimaldo M, Macías-Rubalcava ML, González-Andrade M, Raja H, FigueroaM, Mata R.α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors from Malbrancheacircinata.J Nat Prod. 2020 Jan 3 83, 3, 675–683 doi: 10.1021/acs.jnatprod.9b01108

24. Meléndez TA, Huanosta-Gutiérrez A, Barriga-Montoya C, González-Andrade M, Gómez-Lagunas F.Dronedarone blockage of the tumor-related Kv10.1 channel: a comparison withamiodarone.2 Pflugers Arch. 2020 Jan;4721:7587 doi: https://doi.org/101007s00424019023428

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx