EL VIRUS DE EPSTEIN BARR Y HELICOBACTER PYLORI EN CÁNCER GÁSTRICO
El cáncer gástrico (CG) es el quinto tipo de cáncer más común y la tercera causa de muerte por cáncer en México y el mundo. El CG progresa a partir de una serie de lesiones inflamatorias de incrementada gravedad que inician con una gastritis no atrófica y terminan en cáncer. El daño a tejido inducido por la inflamación crónica en respuesta a la infección por la bacteria Helicobacter pylori (HP) se considera el principal factor de riesgo para desarrollar CG. Nuestros datos apoyan que EBV coopera importantemente con HP para aumentar el riesgo de una inflamación grave y daño tisular gástrico severo con un riesgo incrementado de progresión a cáncer gástrico. De hecho, las cepas de HP más patogénicas en ausencia de EBV inducen inflamación y daño moderado en la mucosa gástrica. Esto tiene varias implicaciones en salud pública: además del gasto económico al tratar a los pacientes de cáncer, la serie de lesiones inflamatorias tempranas como gastritis y úlceras también son causa de malestares serios que originan menor rendimiento académico y laboral, además de un gasto significativo en su tratamiento. Actualmente estamos estudiando los mecanismos moleculares a través de los cuales HP y EBV interactúan e incrementan el daño a la mucosa gástrica.

Publicaciones

1: Sánchez-Ponce Y, Fuentes-Pananá EM. Molecular and immune interactions between
β- and γ-herpesviruses in the immunocompromised host. J Leukoc Biol. 2022
Jul;112(1):79-95. doi: 10.1002/JLB.4MR1221-452R. Epub 2022 Jan 20. PMID:
35060655.

2: Sánchez-Ponce Y, Fuentes-Pananá EM. The Role of Coinfections in the EBV-Host
Broken Equilibrium. Viruses. 2021 Jul 19;13(7):1399. doi: 10.3390/v13071399.
PMID: 34372605; PMCID: PMC8310153.

3: Gajón JA, Juarez-Flores A, De León Rodríguez SG, Aguilar Flores C, Mantilla
A, Fuentes-Pananá EM, Bonifaz LC. Immunotherapy Options for Acral Melanoma, A
fast-growing but Neglected Malignancy. Arch Med Res. 2022 Dec;53(8):794-806.
doi: 10.1016/j.arcmed.2022.11.008. Epub 2022 Nov 30. PMID: 36460547.

4: Fontes-Lemus JI, Zhao I, Rabkin CS, Fuentes-Pananá EM. Antibodies Against
Epstein-Barr Virus as Disease Markers of Gastric Cancer: A Systematic Review.
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231169875. doi:
10.1177/15330338231169875. PMID: 37078150; PMCID: PMC10126687.

5: Vásquez-Echeverri E, Yamazaki-Nakashimada MA, Venegas Montoya E, Scheffler
Mendoza SC, Castano-Jaramillo LM, Medina-Torres EA, González-Serrano ME,
Espinosa-Navarro M, Bustamante Ogando JC, González-Villarreal MG, Ortega
Cisneros M, Valencia Mayoral PF, Consuelo Sanchez A, Varela-Fascinetto G,
Ramírez-Uribe RMN, Salazar Gálvez Y, Bonifaz Alonzo LC, Fuentes-Pananá EM, Gómez
Hernández N, Rojas Maruri CM, Casanova JL, Espinosa-Padilla SE, Staines Boone
AT, López-Velázquez G, Boisson B, Lugo Reyes SO. Is Your Kid Actin Out? A Series
of Six Patients With Inherited Actin-Related Protein 2/3 Complex Subunit 1B
Deficiency and Review of the Literature. J Allergy Clin Immunol Pract. 2023
Apr;11(4):1261-1280.e8. doi: 10.1016/j.jaip.2022.12.045. Epub 2023 Jan 25. PMID:
36708766; PMCID: PMC10085853.

6: León-Letelier RA, Bonifaz LC, Fuentes-Pananá EM. OMIC signatures to
understand cancer immunosurveillance and immunoediting: Melanoma and immune
cells interplay in immunotherapy. J Leukoc Biol. 2019 May;105(5):915-933. doi:
10.1002/JLB.MR0618-241RR. Epub 2019 Jan 30. PMID: 30698862.

7: Chabay P, Lens D, Hassan R, Rodríguez Pinilla SM, Valvert Gamboa F, Rivera I,
Huamán Garaicoa F, Ranuncolo SM, Barrionuevo C, Morales Sánchez A, Scholl V, De
Matteo E, Preciado MV, Fuentes-Pananá EM. Lymphotropic Viruses EBV, KSHV and
HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-
Based Study by the RIAL-CYTED. Cancers (Basel). 2020 Aug 4;12(8):2166. doi:
10.3390/cancers12082166. PMID: 32759793; PMCID: PMC7464376.

8: Duque X, Mendoza E, Morán S, Suárez-Arriaga MC, Morales-Sánchez A, Fontes-
Lemus JI, Domínguez-Martínez DA, Fuentes-Pananá EM. Epstein-Barr Virus Infection
Is Associated with Elevated Hepcidin Levels. Int J Mol Sci. 2023 Jan
13;24(2):1630. doi: 10.3390/ijms24021630. PMID: 36675141; PMCID: PMC9862144.

9: De León-Rodríguez SG, Aguilar-Flores C, Gajón JA, Juárez-Flores Á, Mantilla
A, Gerson-Cwilich R, Martínez-Herrera JF, Villegas-Osorno DA, Gutiérrez-Quiroz
CT, Buenaventura-Cisneros S, Sánchez-Prieto MA, Castelán-Maldonado E, Rivera
Rivera S, Fuentes-Pananá EM, Bonifaz LC. TCF1-positive and TCF1-negative TRM CD8
T cell subsets and cDC1s orchestrate melanoma protection and immunotherapy
response. J Immunother Cancer. 2024 Jul 5;12(7):e008739. doi:
10.1136/jitc-2023-008739. PMID: 38969523; PMCID: PMC11227852.

10: Rozmyslowicz T, Arévalo-Romero H, Conover DO, Fuentes-Pananá EM, León-Juárez
M, Gaulton GN. A Highly Sensitive Molecular Technique for RNA Virus Detection.
Cells. 2024 May 9;13(10):804. doi: 10.3390/cells13100804. PMID: 38786028; PMCID:
PMC11120490.

11: Suárez-Arriaga MC, Méndez-Tenorio A, Pérez-Koldenkova V, Fuentes-Pananá EM.
Claudin-Low Breast Cancer Inflammatory Signatures Support Polarization of
M1-Like Macrophages with Protumoral Activity. Cancers (Basel). 2021 May
7;13(9):2248. doi: 10.3390/cancers13092248. PMID: 34067089; PMCID: PMC8125772.

12: Carreón-Talavera R, Santana-Sánchez P, Fuentes-Pananá EM, Legorreta-Haquet
MV, Chávez-Sánchez L, Gorocica-Rosete PS, Chávez-Rueda AK. Prolactin promotes
proliferation of germinal center B cells, formation of plasma cells, and
elevated levels of IgG3 anti-dsDNA autoantibodies. Front Immunol. 2022 Oct
25;13:1017115. doi: 10.3389/fimmu.2022.1017115. PMID: 36389691; PMCID:
PMC9641231.

13: Domínguez-Martínez DA, Fontes-Lemus JI, García-Regalado A, Juárez-Flores Á,
Fuentes-Pananá EM. IL-8 Secreted by Gastric Epithelial Cells Infected with
Helicobacter pylori CagA Positive Strains Is a Chemoattractant for
Epstein-Barr Virus Infected B Lymphocytes. Viruses. 2023 Feb 28;15(3):651. doi:
10.3390/v15030651. PMID: 36992360; PMCID: PMC10054738.

14: Morales-Sánchez A, Torres J, Cardenas-Mondragón MG, Romo-González C,
Camorlinga-Ponce M, Flores-Luna L, Fuentes-Pananá EM. Detection of Epstein-Barr
Virus DNA in Gastric Biopsies of Pediatric Patients with Dyspepsia. Pathogens.
2020 Jul 30;9(8):623. doi: 10.3390/pathogens9080623. PMID: 32751557; PMCID:
PMC7459453.

15: López-Huerta E, Fuentes-Pananá EM. A Bioinformatic Pipeline Places STAT5A as
a miR-650 Target in Poorly Differentiated Aggressive Breast Cancer. Int J Mol
Sci. 2020 Oct 19;21(20):7720. doi: 10.3390/ijms21207720. PMID: 33086498; PMCID:
PMC7589888.

16: Alemán-García YP, Vaquero-García RM, Flores-Fernández R, Fuentes-Pananá EM,
Gorocica-Rosete P, Pizaña-Venegas A, Chávez-Sanchéz L, Blanco-Favela F,
Legorreta-Haquet MV, Chávez-Rueda AK. Prolactin Increases the Frequency of
Follicular T Helper Cells with Enhanced IL21 Secretion and OX40 Expression in
Lupus-Prone MRL/lpr Mice. J Immunol Res. 2021 Mar 8;2021:6630715. doi:
10.1155/2021/6630715. PMID: 33763492; PMCID: PMC7963914.

17: Aponte-López A, Enciso J, Muñoz-Cruz S, Fuentes-Pananá EM. An In Vitro Model
of Mast Cell Recruitment and Activation by Breast Cancer Cells Supports Anti-
Tumoral Responses. Int J Mol Sci. 2020 Jul 26;21(15):5293. doi:
10.3390/ijms21155293. PMID: 32722549; PMCID: PMC7432939.

18: De Leon-Rodríguez SG, Aguilar-Flores C, Gajón JA, Mantilla A, Gerson-Cwilich
R, Martínez-Herrera JF, Rodríguez-Soto BE, Gutiérrez-Quiroz CT, Pérez-Koldenkova
V, Muñoz-Cruz S, Bonifaz LC, Fuentes-Pananá EM. Acral Melanoma Is Infiltrated
with cDC1s and Functional Exhausted CD8 T Cells Similar to the Cutaneous
Melanoma of Sun-Exposed Skin. Int J Mol Sci. 2023 Mar 1;24(5):4786. doi:
10.3390/ijms24054786. PMID: 36902214; PMCID: PMC10003718.

19: De León Rodríguez SG, Hernández Herrera P, Aguilar Flores C, Pérez
Koldenkova V, Guerrero A, Mantilla A, Fuentes-Pananá EM, Wood C, Bonifaz LC. A
Machine Learning Workflow of Multiplexed Immunofluorescence Images to
Interrogate Activator and Tolerogenic Profiles of Conventional Type 1 Dendritic
Cells Infiltrating Melanomas of Disease-Free and Metastatic Patients. J Oncol.
2022 Oct 12;2022:9775736. doi: 10.1155/2022/9775736. PMID: 36276271; PMCID:
PMC9581597.

20: Rojas-Rechy MH, Gaytán-Morales F, Sánchez-Ponce Y, Castorena-Villa I, López-
Martínez B, Parra-Ortega I, Escamilla-Núñez MC, Méndez-Tenorio A, Pompa-Mera EN,
Martinez-Ruiz GU, Fuentes-Pananá EM, Morales-Sánchez A. Herpesvirus Screening in
Childhood Hematopoietic Transplant Reveals High Systemic Inflammation in
Episodes of Multiple Viral Detection and an EBV Association with Elevated IL-1β,
IL-8 and Graft-Versus-Host Disease. Microorganisms. 2022 Aug 22;10(8):1685. doi:
10.3390/microorganisms10081685. PMID: 36014102; PMCID: PMC9414306.

21: Flores-Fernández R, Aponte-López A, Suárez-Arriaga MC, Gorocica-Rosete P,
Pizaña-Venegas A, Chávez-Sanchéz L, Blanco-Favela F, Fuentes-Pananá EM, Chávez-
Rueda AK. Prolactin Rescues Immature B Cells from Apoptosis-Induced BCR-
Aggregation through STAT3, Bcl2a1a, Bcl2l2, and Birc5 in Lupus-Prone MRL/lpr
Mice. Cells. 2021 Feb 4;10(2):316. doi: 10.3390/cells10020316. PMID: 33557010;
PMCID: PMC7913714.

22: Pérez-Pérez D, Fuentes-Pananá EM, Flores-Hermenegildo JM, Romero-Ramirez H,
Santos-Argumedo L, Kilimann MW, Rodríguez-Alba JC, Lopez-Herrera G.
Lipopolysaccharide-responsive beige-like anchor is involved in regulating NF-κB
activation in B cells. Front Immunol. 2024 Jul 15;15:1409434. doi:
10.3389/fimmu.2024.1409434. PMID: 39076990; PMCID: PMC11284061.

23: Huanosta-Murillo E, Alcántara-Hernández M, Hernández-Rico B, Victoria-Acosta
G, Miranda-Cruz P, Domínguez-Gómez MA, Jurado-Santacruz F, Patiño-López G,
Pérez-Koldenkova V, Palma-Guzmán A, Licona-Limón P, Fuentes-Pananá EM, Lemini-
López A, Bonifaz LC. NLRP3 Regulates IL-4 Expression in TOX+
CD4+ T Cells of Cutaneous T Cell Lymphoma to Potentially Promote
Disease Progression. Front Immunol. 2021 Jun 16;12:668369. doi:
10.3389/fimmu.2021.668369. PMID: 34220814; PMCID: PMC8244903.

24: Ruiz-Rodríguez VM, Turiján-Espinoza E, Guel-Pañola JA, García-Hernández MH,
Zermeño-Nava JJ, López-López N, Bernal-Silva S, Layseca-Espinosa E, Fuentes-
Pananá EM, Estrada-Sánchez AM, Portales-Pérez DP. Chemoresistance in Breast
Cancer Patients Associated With Changes in P2X7 and A2A Purinergic Receptors in
CD8+ T Lymphocytes. Front Pharmacol. 2020 Nov 30;11:576955. doi:
10.3389/fphar.2020.576955. PMID: 33364951; PMCID: PMC7750810.

25: Sánchez-Ponce Y, Murillo-Eliosa JR, Morales-Sanchez A, Fuentes-Pananá EM.
Cytokine Dynamics and Herpesvirus Interactions in Pediatric Liver and Kidney
Transplant Recipients: The Distinct Behavior of HCMV, HHV6, HHV7 and EBV.
Viruses. 2024 Jul 2;16(7):1067. doi: 10.3390/v16071067. PMID: 39066229; PMCID:
PMC11281388.

26: Espinoza-Sánchez NA, Győrffy B, Fuentes-Pananá EM, Götte M. Differential
impact of classical and non-canonical NF-κB pathway-related gene expression on
the survival of breast cancer patients. J Cancer. 2019 Aug 28;10(21):5191-5211.
doi: 10.7150/jca.34302. PMID: 31602271; PMCID: PMC6775609.

27: León-Letelier RA, Castro-Medina DI, Badillo-Godinez O, Tepale-Segura A,
Huanosta-Murillo E, Aguilar-Flores C, De León-Rodríguez SG, Mantilla A, Fuentes-
Pananá EM, López-Macías C, Bonifaz LC. Induction of Progenitor Exhausted Tissue-
Resident Memory CD8+ T Cells Upon Salmonella Typhi Porins
Adjuvant Immunization Correlates With Melanoma Control and Anti-PD-1
Immunotherapy Cooperation. Front Immunol. 2020 Nov 6;11:583382. doi:
10.3389/fimmu.2020.583382. PMID: 33240271; PMCID: PMC7682137.

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx