Contacto
Campos de conocimiento
Ciencias Genómicas
Líneas de investigación
Los principales intereses de investigación son la proteómica del cáncer, centrándose en el secretoma, la dinámica tumoral, la proteómica cuantitativa, la fosforilación de proteínas y la estequiometría de la ubiquitinación y la acetilación.
Publicaciones
1.- The Salmonella enterica Serovar Typhi ltrR Gene Encodes Two Proteins Whose Transcriptional Expression Is Upregulated by Alkaline pH and Repressed at Their Promoters and Coding Regions by H-NS and Lrp. Rebollar-Flores JE, Medina-Aparicio L, Osio-Becerro VE, Villarreal JM, Mayo S, Mendoza BD, Rodríguez-Gutierrez S, Olvera L, Dávila S, Encarnación S, Martínez-Batallar AG, Calva E, Hernández-Lucas I. J Bacteriol. 2020, 9;202(13):e00783-19. doi: 10.1128/JB.00783-19. Print 2020 Jun 9.
2.- Nitrogen fixation in pozol, a traditional fermented beverage. Rizo J, Rogel MA, Guillén D, Wacher C, Martinez-Romero E, Encarnación S, Sánchez S, Rodríguez-Sanoja R. Appl Environ Microbiol. 2020, 3:86 (16): e00588-20 doi: 10.1128/AEM.00588-20.
3.- Protein expression profile of Taenia crassiceps cysticerci related to Th1- and Th2-type responses in the mouse cysticercosis model. Díaz-Zaragoza M, Jiménez L, Hernández M, Hernández-Ávila R, Navarro L, Ochoa-Sánchez A, Encarnación-Guevara S, Ostoa-Saloma P, Landa. A. Acta Trop. 2020 Dec;212:105696. doi: 10.1016/j.actatropica.2020.105696. Epub 2020 Sep 19.
4.- Principal component analysis on LC‑MS/MS and 2DE‑MALDI‑TOF in glioblastoma cell lines reveals that mitochondria act as organelle sensors of the metabolic state in glioblastoma. Gómez-Caudillo L, Ortega-Lozano AJ, Martínez-Batallar ÁG, Rosas-Vargas H, Minauro-Sanmiguel F, Encarnación-Guevara S. Oncol Rep. 2020 44(2):661-673. doi: 10.3892/or.2020.7625.
5.- RhizoBindingSites, a Database of DNA-Binding Motifs in Nitrogen-Fixing Bacteria Inferred Using a Footprint Discovery Approach. Taboada-Castro H, Castro-Mondragón JA, Aguilar-Vera A, Hernández-Álvarez AJ, van Helden J, Encarnación-Guevara S. Front Microbiol. 2020 Nov 5;11:567471. doi: 10.3389/fmicb.2020.567471. eCollection 2020.
6.- Transcriptomic analysis of Burkholderia cenocepacia CEIB S5-2 during methyl parathion degradation. Ma. Laura Ortiz-Hernández, Yitzel Gama-Martínez, Maikel Fernández-López, María Luisa Castrejón-Godínez, Sergio Encarnación, Efraín Tovar-Sánchez, Emmanuel Salazar, Alexis Rodríguez, Patricia Mussali-Galante. Environ Sci Pollut Res Int. 2021 Apr 4. doi: 10.1007/s11356-021-13647-6.
7.- Effect of HPV 16 E6 Oncoprotein Variants on the Alterations of the Proteome of C33A Cells. Olga Lilia Garibay-Cerdenares, Luz Victoria Sánchez-Meza, Sergio Encarnación-Guevara, Magdalena Hernández-Ortíz, Gabriel Martínez-Batallar, Francisco Israel Torres-Rojas, Miguel Ángel Mendoza-Catalán, Oscar Del Moral-Hernández, Marco Antonio Leyva-Vázquez, Berenice Illades-Aguiar. Cancer Genomics Proteomics. May-Jun 2021;18(3):273-283. doi: 10.21873/cgp.20258. Epub 2021 Apr 23.
8.- Curcumin Reverts the Protein Differential Expression in the Liver of the Diabetic Obese db/db mice. Oscar Gerardo Silva-Gaona; Juan Manuel Guzmán-Flores; Magdalena Hernández-Ortiz; Katya Vargas-Ortiz; Joel Ramírez-Emiliano; Sergio Encarnación-Guevara; Victoriano Perez-Vazquez. Current Proteomics. 2021, 18: 1-12 DOI: 10.2174/1570164618666210114112642
9.- The CRISPR-Cas System Is Involved in OmpR Genetic Regulation for Outer Membrane Protein Synthesis in Salmonella Typhi.
Medina-Aparicio L, Rodriguez-Gutierrez S, Rebollar-Flores JE, Martínez-Batallar ÁG, Mendoza-Mejía BD, Aguirre-Partida ED, Vázquez A, Encarnación S, Calva E, Hernández-Lucas I. Front Microbiol. 2021 Mar 29;12:657404. doi: 10.3389/fmicb.2021.657404. eCollection 2021. PMID: 33854491
10.- Analysis of the immunomodulatory activity of excreted and secreted products from Haemonchus placei transition infective larvae (xL3). Maza-Lopez J, Contreras-Ochoa CO, Reyes-Guerrero DE, Encarnación-Guevara S, Hernández-Ortíz M, Olmedo-Juárez A, López-Arellano ME. Vet Parasitol. 2021 Jul 8;298:109512. doi: 10.1016/j.vetpar.2021.109512. PMID: 34271321
11.- Metaproteomic Insights Into the Microbial Community in Pozol.
Rizo J, Guillén D, Díaz-Ruiz G, Wacher C, Encarnación S, Sánchez S, Rodríguez-Sanoja R.
Frontiers Nutrition. 2021 Aug 20;8:714814. doi: 10.3389/fnut.2021.714814. eCollection 2021. Online ISSN: 2296-861X , PMID: 34490328
12.- Phenotypic plasticity and a new small molecule are involved in a fungal-bacterial interaction.
Andrade-Domínguez A, Trejo-Hernández A, Vargas-Lagunas C, Encarnación-Guevara S.
Scientific Reports. 2021 Sep 28;11(1):19219. doi: 10.1038/s41598-021-98474-y.
PMID: 34584120, ISSN 2045-2322 (online).
13.- Interaction of the human intestinal microbiota with the release of bound phenolic compounds in chickpea (Cicer arietinum L.). Liliana Maribel Perez-Perez, José Ángel Huerta-Ocampo, José Rogelio Ramos-Enríquez, Saúl Ruiz-Cruz, Francisco Javier Wong-Corral, Ema Carina Rosas-Burgos, Magdalena Hernández-Ortíz, Sergio Encarnación-Guevara, Miguel Ángel Robles-García, Rey David Iturralde-García, Jesús Borboa-Flores, Carmen Lizette Del-Toro-Sánchez. International Journal of Food Science and Technology 2021, 56, 6497–6506. https://doi.org/10.1111/ijfs.15351. Online ISSN:1365-2621
14.- Protein lysine acetylation and its role in different human pathologies: a proteomic approach.
Morales-Tarré O, Alonso-Bastida R, Arcos-Encarnación B, Pérez-Martínez L, Encarnación-Guevara S. Expert Rev Proteomics. 2021 Nov 18. doi: 10.1080/14789450.2021.2007766. PMID: 34791964. Print ISSN: 1478-9450 Online ISSN: 1744-8387
15.-Quantitative Proteomic Analysis of Cervical Cancer Tissues Identifies Proteins Associated with Cancer Progression
Alberto Ramírez-Torres, Jeovanis Gil, Sandra Contreras, Graciela Ramírez, Heriberto A Valencia-González, Emmanuel Salazar-Bustamante, Leopoldo Gómez-Caudillo, Alejandro García-Carranca, Sergio Encarnación-Guevara. Cancer Genomics Proteomics 2022;19(2):241-258. doi: 10.21873/cgp.20317.
16.- Curcumin Prevents the Glycation of Tricarboxylic Acid Cycle and Cell Respiration Proteins in the Heart of Mice Fed with a High-Fructose Diet
María Cristina León-García, Oscar Gerardo Silva-Gaona, Magdalena Hernández-Ortiz, Katya Vargas-Ortiz, Joel Ramírez-Emiliano, Ma Eugenia Garay-Sevilla, Sergio Encarnación-Guevara, Victoriano Pérez-Vázquez. Curr Pharm Des. 2022 Mar 31. doi: 10.2174/1381612828666220331160501.
17.- Proteomic analysis reveals the metabolic versatility of Amycolatopsis sp. BX17: A strain native from milpa agroecosystem soil. Michel Palafox-Félix, José Ángel Huerta-Ocampo, Magdalena Hernández-Ortíz, Sergio Encarnación-Guevara, Luz Vázquez-Moreno, Ana María Guzmán-Partida, Rosina Cabrera. J Proteomics. 2022, 253:104461. doi: 10.1016/j.jprot.2021.104461.
18.- A Tar aspartate receptor and Rubisco-like protein substitute biotin in the growth of rhizobial strains. Vargas-Lagunas C, Mora Y, Aguilar A, Reyes-González AR, Arteaga-Ide A, Dunn MF, Encarnación S, Girard L, Peralta H, Mora J. Microbiology (Reading). 2022 Jan;168(1):001130. doi: 10.1099/mic.0.001130.
19.- The human bile salt sodium deoxycholate induces metabolic and cell envelope changes in Salmonella Typhi leading to bile resistance. Olivar-Casique IB, Medina-Aparicio L, Mayo S, Gama-Martínez Y, Rebollar-Flores JE, Martínez-Batallar G, Encarnación S, Calva E, Hernández-Lucas I. J Med Microbiol. 2022 Jan;71(1). doi: 10.1099/jmm.0.001461. PMID: 35006066
20.- Curcumin Prevents Proteins Expression Changes of Oxidative Phosphorylation, Cellular Stress Response, and Lipid Metabolism Proteins in liver of Mice Fed a High-Fructose Diet. Silva-Gaona OG, Hernández-Ortiz M, Vargas-Ortiz K, Ramírez-Emiliano J, Garay-Sevilla ME, Encarnación-Guevara S, Pérez-Vázquez V. J Proteomics. 2022. 15;263:104595. doi: 10.1016/j.jprot.2022.104595. Epub 2022 Apr 29.
21.- Specialized acyl carrier protein used by serine palmitoyltransferase to synthesize sphingolipids in Rhodobacteria. Padilla-Gómez J, Olea-Ozuna RJ, Contreras-Martínez S, Morales-Tarré O, García-Soriano DA, Sahonero-Canavesi DX, Poggio S, Encarnación-Guevara S, López-Lara IM, Geiger O. Front Microbiol. 2022 4;13:961041. doi: 10.3389/fmicb.2022.961041. eCollection 2022.
22.- Curcumin Prevents the Glycation of Tricarboxylic Acid Cycle and Cell Respiration Proteins in the Heart of Mice Fed with a High-fructose Diet. León-García MC, Silva-Gaona OG, Hernández-Ortiz M, Vargas-Ortiz K, Ramírez-Emiliano J, Garay-Sevilla ME, Encarnación-Guevara S, Pérez-Vázquez V. Curr Pharm Des. 2022. 28(21):1769-1778. doi: 10.2174/1381612828666220331160501.
23.- R. etli CFN42 proteomes showed isoenzymes in free-living and symbiosis with a different transcriptional regulation inferred from a transcriptional regulatory network... Hermenegildo Taboada Castro,Jeovanis Gil, Leopoldo Gómez Caudillo,Juan Miguel Escorcia-Rodríguez,Julio Augusto Freyre-Gonzalez,Sergio Encarnacion-Guevara. Front. Microbiol. DOI: 10.3389/fmicb.2022.947678
24.- Impact of c-di-GMP on the Extracellular Proteome of Rhizobium etli. María J Lorite 1, Ariana Casas-Román 1, Lourdes Girard 2, Sergio Encarnación 2, Natalia Díaz-Garrido 3, Josefa Badía 3 4, Laura Baldomá 3, Daniel Pérez-Mendoza 1, Juan Sanjuán 1 Biology (Basel). 2022 Dec 26;12(1):44. doi: 10.3390/biology12010044.
25.- Proteomic analysis of Burkholderia zhejiangensis CEIB S4-3 during the methyl parathion degradation process.
Castrejón-Godínez ML, Tovar-Sánchez E, Ortiz-Hernández ML, Encarnación-Guevara S, Martínez-Batallar ÁG, Hernández-Ortiz M, Sánchez-Salinas E, Rodríguez A, Mussali-Galante P.
Pestic Biochem Physiol. 2022 Oct;187:105197. doi: 10.1016/j.pestbp.2022.105197. Epub 2022 Aug 6.
26.- Proteomic analysis of the biomineralization of spherical Brushite produced from a wheat bran aqueous extract. Iván Jalil Antón Carreño-Márquez, René Renato Balandrán-Quintana, José Antonio Azamar-Barrios, José Ángel Huerta-Ocampo, Ana María Mendoza-Wilson, Gabriela Ramos-Clamont Montfort, Sergio Encarnación-Guevara, Magdalena Hernández-Ortiz. Food Bioscience. Vol 53, June 2023, 102692. doi: https://doi.org/10.1016/j.fbio.2023.102692
27.- Differential Protein Expression of Taenia crassiceps ORF Strain in the Murine Cysticercosis Model Using Resistant (C57BL/6) Mice. Lucía Jiménez, Mariana Díaz-Zaragoza, Magdalena Hernández, Luz Navarro, Ricardo Hernández-Ávila, Sergio Encarnación-Guevara, Pedro Ostoa-Saloma, Abraham Landa. Pathogens. 2023, 4;12(5):678. doi: 10.3390/pathogens12050678.
28.- Proteomics and bioinformatics tools reveal allergenic composition of Parkinsonia microphylla pollen. Martha Beatriz Morales-Amparano, Daniela Álvarez-Campa, Magdalena Hernández-Ortiz, Sergio Encarnación-Guevara, Luis Manuel Terán-Juárez y José Ángel Huerta-Ocampo. (2022). Avances en Ciencias e Ingeniería, 13(3), 23-30 ISSN: 0718-8706.
29.- A proteomic overview of the major venom components from Tityus championi from Panama. Salazar MH, Ortíz MH, Encarnación S, Zamudio F, Possani LD, Cleghorn J, Morán M, Acosta H, Corzo G. Toxicon. 2023 May;227:107082. doi: 10.1016/j.toxicon.2023.107082.
30.-The transmembrane proteins (TMEM) and their role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition in cancer. Gloria Angelina Herrera-Quiterio and Sergio Encarnación-Guevara. Front Oncol. 2023 Oct 23:13:1244740. doi: 10.3389/fonc.2023.1244740.
31.- Studying the proteome and the influence of edaphic factors on the production of perezone in roots of wild plants of Acourtia cordata. Ma del Carmen García-Méndez, Sergio Encarnación-Guevara, Gabriel Martínez-Batallar, Leopoldo Gómez-Caudillo, Roque Bru-Martínez, Ascensión Martínez-Márquez, Susana Selles-Marchant, Efraín Tovar-Sánchez, Laura Álvarez-Berber, Silvia Marquina, Irene Perea-Arango and José de Jesús Arellano-García. PeerJ. 2023 Nov 15;11:e16136. doi: 10.7717/peerj.16136. eCollection 2023
32.- Dynamics of Mitochondrial Proteome and Acetylome in Glioblastoma Cells with Contrasting Metabolic Phenotypes. Diana Lashidua Fernández-Coto, Jeovanis Gil, Guadalupe Ayala, Sergio Encarnación-Guevara. Int J Mol Sci. 2024 Mar 19;25(6):3450. doi: 10.3390/ijms25063450.
33- Bioinformatics Analysis of Human Papillomavirus 16 Integration in Cervical Cancer: Changes in MAGI-1 Expression in Premalignant Lesions and Invasive Carcinoma. Catalán-Castorena O, Garibay-Cerdenares OL, Illades-Aguiar B, Castillo-Sánchez R, Zubillaga-Guerrero MI, Leyva-Vazquez MA, Encarnacion-Guevara S, Flores-Alfaro E, Ramirez-Ruano M, Del Carmen Alarcón-Romero L. Cancers (Basel). 2024 Jun 14;16(12):2225. doi: 10.3390/cancers16122225.
34- Bacterial protein acetylation: mechanisms, functions, and methods for study.
Rizo J, Encarnación-Guevara S.
Front Cell Infect Microbiol. 2024 Jul 4;14:1408947. doi: 10.3389/fcimb.2024.1408947. eCollection 2024.
35.- Exploring the protein profile and biological activity of Crotalus molossus venom against E. coli, P. aeruginosa and S. aureus bacteria and T47D breast carcinoma cells.
Jimenez-Canale J, Navarro-Lopez R, Huerta-Ocampo JA, Burgara-Estrella AJ, Encarnacion-Guevara S, Silva-Campa E, Velazquez-Contreras FE, Sarabia-Sainz JA.
Toxicon. 2024 Oct;249:108036. doi: 10.1016/j.toxicon.2024.108036. Epub 2024 Jul 24.
36- The role of HR-HPV integration in the progression of premalignant lesions into different cancer types.
Catalán-Castorena O, Garibay-Cerdenares OL, Illades-Aguiar B, Rodríguez-Ruiz HA, Zubillaga-Guerrero MI, Leyva-Vázquez MA, Encarnación-Guevara S, Alarcón-Romero LDC. Heliyon. 2024 Jul 22;10(15):e34999. doi: 10.1016/j.heliyon.2024.e34999. eCollection 2024 Aug 15.
37- Rhizobium etli CFN42 and Sinorhizobium meliloti 1021 bioinformatic transcriptional regulatory networks from culture and symbiosis.
Taboada-Castro H, Hernández-Álvarez AJ, Escorcia-Rodríguez JM, Freyre-González JA, Galán-Vásquez E, Encarnación-Guevara S.
Front Bioinform. 2024 Aug 28;4:1419274. doi: 10.3389/fbinf.2024.1419274. eCollection 2024.
38.- MAYEX is an old long noncoding RNA recruited for X chromosome dosage compensation in a reptile.
Tenorio M, Cruz-Ruiz S, Encarnación-Guevara S, Hernández M, Corona-Gomez JA, Sheccid-Santiago F, Serwatowska J, López-Perdomo S, Flores-Aguirre CD, Arenas-Moreno DM, Ossiboff RJ, Méndez-de-la-Cruz F, Fernandez-Valverde SL, Zurita M, Oktaba K, Cortez D.
Science. 2024 Sep 20;385(6715):1347-1354. doi: 10.1126/science.adp1932. Epub 2024 Sep 19.
39- RhizoBindingSites v2.0 Is a Bioinformatic Database of DNA Motifs Potentially Involved in Transcriptional Regulation Deduced From Their Genomic Sites.
Taboada-Castro H, Hernández-Álvarez AJ, Castro-Mondragón JA, Encarnación-Guevara S.
Bioinform Biol Insights. 2024 Sep 6;18:11779322241272395. doi: 10.1177/11779322241272395. eCollection 2024.
40.- TMEM160 Promotes Tumor Growth in Lung Adenocarcinoma and Cervical Adenocarcinoma Cell Lines.
Herrera-Quiterio GA, Valencia-González HA, de la Cruz-López KG, Fernández-Coto DL, Gil J, Marko-Varga G, Morales-Gálvez J, Sánchez NC, Rodríguez-Bautista R, Avilés-Salas A, Arrieta O, García-Carrancá A, Encarnación-Guevara S.
Int J Mol Sci. 2025 Jan 27;26(3):1097. doi: 10.3390/ijms26031097.
41.-The LysR-type transcriptional regulator STY2660 is involved in outer membrane protein synthesis, bile resistance and motility in Salmonella enterica serovar Typhi.
Gama-Martínez Y, Hernández VM, Encarnación-Guevara S, Martínez-Batallar Á, Hernández-Lucas I.
Front Microbiol. 2025 Feb 26;16:1554102. doi: 10.3389/fmicb.2025.1554102. eCollection 2025.
42.- Revisiting toxins with transcriptomics-informed proteomics of venom glands and crude venom from Centruroides bicolor from Panama.
Samudio O, Hernández-Ortiz M, Clement H, Encarnación-Guevara S, Cleghorn J, Acosta H, Corzo G, Salazar MH.
J Proteomics. 2025 May 30;316:105415. doi: 10.1016/j.jprot.2025.105415. Epub 2025 Mar 6.
43.- Transcriptomics-Informed Proteomics of Venom Glands and Crude Venom from Tityus cf. Asthenes from Panama: Enzymes, Proteins, Toxins, and Antimicrobial Peptides.
Salazar MH, Samudio O, Arenas I, Hernández-Ortiz M, Clement H, Hernandez-Orihuela L, Encarnación-Guevara S, Cleghorn J, Acosta H, Corzo G.
J Proteome Res. 2025 May 28. doi: 10.1021/acs.jproteome.5c00125. Online ahead of print.
44.- Comprehensive biobanking strategy with clinical impact at the European Cancer Moonshot Lund Center.
Oskolas H, Nogueira FCN, Domont GB, Yu KH, Semenov YR, Sorger P, Steinfelder E, Corps L, Schulz L, Wieslander E, Fenyö D, Kárpáti S, Holló P, Kemény LV, Döme B, Megyesfalvi Z, Pawłowski K, Nishimura T, Kwon H, Encarnación-Guevara S, Szasz AM, Veréb Z, Gyulai R, Németh IB, Appelqvist R, Rezeli M, Baldetorp B, Horvatovich P, Malmström J, Pla I, Sanchez A, Knudsen B, Kiss A, Malm J, Marko-Varga G, Gil J.
