Control del Metabolismo: Bases Moleculares Reguladoras del Epigenoma y la Estructura Nuclear.
1. Aspectos moleculares y epigenéticos que controlan el reloj circadiano en condiciones de salud y enfermedad: cáncer, neurodegeneración o diabetes y obesidad.
2. Regulación metabólica de la arquitectura nuclear: ritmos circadianos y la estructura 3D del genoma.
3. Control epigenético de la diferenciación de células troncales y su relación con la reprogramación metabólica.

Publicaciones

1. Liu, P; Nadeef, S; Serag, M; Paytuví, A; Abadi, M; Della Valle, F; Adroub, S; Elsaid, N; Fallatah, B; Celii, M; Tognini, P; Aguilar-Arnal, L; Habuchi, S; Masri, S; Orlando; V. EZH1 Orchestrates Rhythmicity of Circadian Gene Expression Acting on Transcription Machinery Integrity. (2024), aceptado en EMBO J (IF 11).

2. Pacheco-Bernal, I; Becerril-Pérez, F; Bustamante-Zepeda, M; González-Suárez, M; Olmedo-Suárez, M; Hernández-Barrientos, LR; Alarcón del Carmen, A; Escalante-Covarrubias, Q; Mendoza-Viveros, L; Hernández-Lémus, E; León del Río, A, De La Rosa-Velázquez, I.A.; Orozco-Solis, R; Aguilar-Arnal, L. (Corr. Auth.) “Transitions in chromatin conformation shaped by fatty acids and the circadian clock underlie hepatic transcriptional reorganization in obese mice.” (2024) Cellular and Molecular Life Sciences (IF 8)

3. González-Suárez, M; Aguilar-Arnal, L. (corr auth.) “Histone methylation: at the crossroad between circadian rhythms in transcription and metabolism" (2024) Frontiers in Genetics. (IF 3.5) DOI: 10.3389/fgene.2024.1343030

4. Sanchez-Ramírez, E; Ung, T.P.L.; Stringari, C; Aguilar-Arnal, L. (corr auth.). “Emerging Functional Connections Between Metabolism and Epigenetic Remodeling in Neural Differentiation”. (2024) Molecular Neurobiology (IF 5,5). DOI: 10.1007/s12035-024-04006-w.

5. Escalante-Covarrubias, Q; Mendoza-Viveros, L; González-Suárez, M; Sitten-Olea, R; Velázquez-Villegas, L.A.; Becerril-Pérez, F; Pacheco-Bernal, I; Carreño-Vázquez, E; Mass-Sánchez, P; Bustamante-Zepeda, M; Orozco-Solis, R; Aguilar-Arnal, L (corr auth) (2023) Time-of-day defines NAD+ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice. Nature Communications 14, 1685.. (IF 17.4)

6. Mendoza-Viveros, L; Marmolejo-Gutierrez, C; Cid-Castro, C; Escalante-Covarrubias, Q; Montellier, E; Carreño-Vázquez, E; Noriega, L.G.; Velázquez-Villegas, L.A.; Tovar, A.R.; Sassone-Corsi, P; Aguilar-Arnal, L; Orozco-Solis, R. (2023) Astrocytic circadian clock control of energy expenditure by transcriptional stress responses in the Ventromedial Hypothalamus. Glia 1– 22. (IF 8.1)

7. Ahmed, A; Syed, J; Wang, X; Chi, L; Perez-Romero, C, Lee, D; Escalante-Covarrubias, Q; Yang, J; Kocaqi, E; Ishimura, A; Suzuki, T; Aguilar-Arnal, L; Bryan Gonzales, G; Kim K-H;, Delgado-Olguín, P. (2023) KDM8 epigenetically controls cardiac metabolism to prevent initiation of dilated cardiomyopathy. Nature Cardiovascular Research, 2, 174-191 https://doi.org/10.1038/s44161-023-00214-0 (IF 9)
Este artículo se comenta en: Bakshi, S., Wende, A.R. KDM8 prevents heart failure by controlling cardiac metabolism. Nature Cardiovascular Research 2, 106–107 (2023)

8. Nuñez-Olvera, S.I.; Aguilar-Arnal, L.; Cisneros-Villanueva, M; Hidalgo-Miranda, A; Marchat, L.A.; y Salinas-Vera, Y.M; Ramos-Payán, R; Pérez-Plasencia, C.; Carlos-Reyes, A.; Puente-Rivera, J.; López-Camarillo, C. (2022) Breast cancer cells reprogram the oncogenic lncRNAs/mRNAs coexpression networks in three-dimensional microenvironment. Cells. (IF 6)

9. Sánchez-Ramírez, E, Ung, TPL; Alarcón del Carmen; A; Del Toro-Rios, X; Fajardo-Orduña, GR; Noriega, LG; Cortés-Morales, V.A.; Tovar, AR; Montesinos, JJ; Orozco-Solis, R; Stringari, C; Aguilar-Arnal, L (corr-auth) (2022) Coordinated metabolic transitions and gene expression by NAD+ during adipogenesis. Journal of Cell Biology 221 (12): e202111137 (IF10.5).
Este artículo se comenta en: Eckel-Mahan, K. Temporal and spatial metabolite dynamics impart control in adipogenesis. Journal of Cell Biology (2022) 221 (12): e202210021.

10. Nuñez-Olvera, S.I.; Puente-Rivera, J.; Ramos-Payán, R.; Pérez-Plasencia, C.; Salinas-Vera, Y.M.; Aguilar-Arnal, L. (Corr auth); López-Camarillo, C. (2021) Three-Dimensional Genome Organization in Breast and Gynecological Cancers: How Chromatin Folding Influences Tumorigenic Transcriptional Programs. Cells 11, 75, IF 6
11. Orozco-Solis, R; Aguilar-Arnal, L (Corr auth) (2020). Circadian regulation of immunity through epigenetic mechanisms, Frontiers in Cellular and Infection Microbiology, 10: 96. (IF 5,7)

12. Pacheco-Bernal, I; Becerril-Perez, F and Aguilar-Arnal, L. (Corr auth) (2019). Circadian rhythms in the three-dimensional genome: implications of chromatin interactions for cyclic transcription, Clinical Epigenetics, 11(1):79. IF 6,1

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

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mdcbq@posgrado.unam.mx