La respuesta inmune al protozoario parásito Trypanosoma cruzi causante de la enfermedad de Chagas.
Mejoramiento de métodos de diagnóstico para la enfermedad de Chagas.
Estudio de factores de virulencia en Trypanosoma cruzi.
Desarrollo de nuevos fármacos para el tratamiento de la Enfermedad de Chagas y Leishmaniasis.

Publicaciones

- Rodríguez-Hernández KD, Martínez I, Agredano-Moreno LT, Jiménez-García LF, Reyes-Chilpa R, Espinoza B. 2019. Coumarins isolated from Calophyllum brasiliense produce ultrastructural alterations and affect in vitro infectivity of Trypanosoma cruzi. Phytomedicine. 2019 Vol 61 (2019) 152827. Doi org/10.1016/j.phymed.2019.152827. FI: 3.610. ISSN: 0944-7113, e-ISSN: 1618-095X.
https://www.sciencedirect.com/science/article/abs/pii/S0944711319300054

- Sepulveda-Robles, O., Espinoza- Gutiérrez B., Juan C. Gomez-Verjanc, Silvia Laura Guzmán-Gutiérrez, Marlon De Itae, Mayra Silva-Miranda, Clara Inés Espitia-Pinzón, Fernando Fernández-Ramírez F., Alma Herrera-Salazar, Minerva Mata-Rocha, Alfredo Ortega-Hernández, Ricardo Reyes-Chilpa, 2019. Trypanocidal and Toxicological assessment in vitro and “in silico” of three sesquiterpene lactones from Asteraceae plant species. Food and Chemical Toxicology, 125(2019): 55-61. Doi: 10.1016/j.fct.2018.12.023 IF 3.977. ISSN: 0278-6915.
https://pubmed.ncbi.nlm.nih.gov/30572063/

- Dopico E, Del-Rei RP, Espinoza B, Ubillos I, Zanchin NIT, Sulleiro E, Moure Z, Celedon PAF, A Souza WV, da Silva ED, Gomes YM, Santos FLN. Immune reactivity to Trypanosoma cruzi chimeric proteins for Chagas disease diagnosis in immigrants living in a non-endemic setting. BMC Infect Dis. 2019 Mar 12;19 (1):251. doi: 10.1186/s12879-019-3872-z. FI: 2.951. ISSN: 1471-2334.
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-019-3872-z

- Espinoza B, Martínez I, Schabib-Hany M. 2019. First report of family clusters of Chagas disease seropositive blood donors in Mexico City and their epidemiological relevance. Acta Trop. 193 (2019) May; 23-30. Doi org/: 10.1016/j.actatropica.2019.02.014. FI: 2.629. ISSN: 0001-706X.
https://www.sciencedirect.com/science/article/abs/pii/S0001706X18314207

- Rodríguez-Hernández K.D., Martínez I., Reyes-Chilpa R., Espinoza B. 2020. Mammea type coumarins isolated from Calophyllum brasiliense induced apoptotic cell death of Trypanosoma cruzi through mitochondrial dysfunction, ROS production and cell cycle alterations. Bioorganic Chemistry. Vol. 100, july 2020, 103894. doi: 10.1016/j.bioorg.2020.103894. FI: 4.8312021 5.4. ISSN: 0045-2068.
https://www.sciencedirect.com/science/article/abs/pii/S0045206820302947

- López-Huerta, Fabiola A. Nieto-Camacho Antonio, Morales-Flores Félix, Hernández-Ortega Simón, Chávez María Isabel, Méndez Cuesta Carlos A., Martínez Ignacio, Espinoza Bertha, Espinosa-García Francisco J., Delgado Guillermo. 2020. Hopane-type triterpenes from Cnidoscolus spinosus and their bioactivities. Bioorganic Chemistry. Vol. 100, July 2020, 103919. https://doi.org/10.1016/j.bioorg.2020.103919. FI 4.831.2021 5.4. ISSN: 0045-2068.
https://pubmed.ncbi.nlm.nih.gov/32417524/

- Cárdenas-Guerra Rosa E., Moreno-Gutierrez David S., Vargas-Dorantes Oscar de J., Espinoza Bertha, Hernandez-Garcia Armando. 2020. Delivery of antisense DNA into pathogenic parasite Trypanosoma cruzi using virus-like protein-based nanoparticles. Nucleic Acid Therapeutics. DOI: 10.1089/nat.2020.0870. FI: 4.875. ISSN: 2159-3337. e-ISSN: 2159-3345.
https://www.liebertpub.com/doi/10.1089/nat.2020.0870

- Arroyo-Olarte RD. Martinez I., Mendlovic F., Lujan E., Dinkova T., and Espinoza B. 2020. Differential translational control of virulence factors modulates infectivity between TcI Trypanosoma cruzi strains. Parasitology Research. DOI: 10.1007/s00436-020-06891-1. FI: 1.641. ISSN: 2090-0023. e- ISSN: 2090-0031.
https://link.springer.com/article/10.1007/s00436-020-06891-1

- Díaz-Valdez J., Martínez I., Rodríguez-Moreno Á., León-Villegas R. I., Gutiérrez-Granados G., Sánchez-Cordero V., Fraga-Nodarse J., Ángeles-Chimal J.ϯ, Espinoza B. 2021. Multiple discrete typing units of Trypanosoma cruzi infect sylvatic Triatoma dimidiata and Pastrongilus rufotuberculatus in southeast Mexico. Am. J. Trop. Med. Hyg. 105 (4) 2021 pp. 1045-1052. Doi: 10.4269/ajtmh.20-1574. ISSN 0002-9637. Online ISSN: 1476-1645. FI: 3.707.
https://pubmed.ncbi.nlm.nih.gov/34398820/

- Aguilar Martínez C. U., Sánchez Martínez S.D., Berruecos-Villalobos, J.M., Valencia, J. Segura-Correa J.C. Roldán-Roldán, A. Espinoza Gutiérrez, B. 2021. Genetic characterization of Pelibuy sheep in México using microsatellites markers. Revista Ciencias Pecuarias. 2021; 12 (1): 36-57. https://doi.org/10.22319/rmcp.v12i1.5106. ISSN 2007-1124. e- ISSN 2448-6698.
file:///C:/Users/Chepinita52/Downloads/Caracterizacion_genetica_de_la_oveja_Pelibuey_de_M.pdf

- Díaz-Garrido P., Cárdenas-Guerra R.E., Martínez I., Poggio S., Rodríguez-Hernández K., Rivera-Santiago L., Ortega-López J., Sánchez-Esquivel S., and Espinoza B. 2021. Differential activity on trypanosomatid parasites of a novel recombinant defensin type 1 from the insect Triatoma (Meccus) pallidipennis. Insect Biochemistry and Molecular Biology. https://doi.org/10.1016/j.ibmb.2021.103673. ISSN: 09651748, 18790240. FI: 4.714.
https://www.sciencedirect.com/science/article/abs/pii/S0965174821001569?via%3Dihub

- Rivera-Santiago, L., Ignacio Martínez, Ruben Arroyo-Olarte, Paulina Díaz-Garrido, Roberto I. Cuevas-Hernandez, and Bertha Espinoza. 2022. Structural new data for mitochondrial peroxiredoxin from Trypanosoma cruzi show high similarity with human peroxiredoxin 3: repositioning Thiostrepton as antichagasic drug. Frontiers Cellular and Infection Microbiology. Doi 103389/fcimb.2022.907043. Online ISSN 2235-2988.
https://www.frontiersin.org/articles/10.3389/fcimb.2022.907043/full

-Dehesa Rodríguez G., Martínez, I., Bastida Jaime, C., Espinoza B. 2022. Trypanosoma cruzi blood trypomastigotes induce intense skeletal and cardiac muscle damage and Th1/ Th2 immune response in the acute phase of mice infected by the oral route. Acta Trop. 2022 Jul 9;234:106605. doi: 10.1016/j.actatropica.2022.106605. Online ahead of print. PMID: 35820470. ISSN: 0001-706X. IF: 3.222
https://www.sciencedirect.com/science/article/abs/pii/S0001706X22002972

- Espinoza. B., Martínez I., Martínez-Velasco, ML., González- Canto A., Terrazas LI., Vázquez-Mendoza A., Rodríguez-Sosa M. 2023. Role of a 49 kDa Trypanosoma cruzi mucin-associated surface protein (MASP49) during the infection process and identification of a mammalian cell surface receptor. 2023. Pathogens. 2023, 12, 105. https://doi.org/10.3390/pathogens1210105.

Espinoza Bertha, Rangel-Flores Hilda, Saucedo-Arteaga Gabriel, Martínez-Martínez Ignacio, Aguilar-Salinas Carlos A., Cabrera-Mendoza Brenda, Ponce-Patiño David, Mendoza-Duarter Javier and Martínez-Rangel Carlos E. 2024. First Report of Seropositivity to Trypanosoma cruzi in Mexican Afro-Descendants from Guerrero and Oaxaca States. Journal of Parasitology Research 2024. Volume 2024, Article ID 2014142, 9 pages. E-ISSN 2090-0031. https://doi.org/10.1155/2024/2014142.

Martínez-Martínez Ignacio, Rivera-Santiago Lucio, Rodríguez-Hernández Karla D., Galván-Hernández Arturo, Rodríguez-Fragoso Lourdes, Díaz-Peralta Lucero, Torres-Martínez Lisset, Agredano-Moreno Lourdes T., Jiménez-García Luis F., Ortega-Blake Iván and Espinoza Bertha. 2024. A Promising Amphotericin B Derivative Induces Morphological Alterations, Mitochondrial Damage, and Oxidative Stress In Vitro and Prevents Mice from Death Produced by a Virulent Strain of Trypanosoma cruzi. Academic Gereon R. M. Schares Editor. Microorganisms 2024, 12, 1064. ISSN 2078-2489. https://doi.org/10.3390/ microorganisms12061064

Carrero Julio C., Espinoza Bertha. Huerta Leonor, Silva-Miranda Mayra, Guzmán-Gutierrez Silvia-Laura, Dorazco-González Alejandro, Reyes-Chilpa Ricardo, Espitia Clara and Sánchez Sergio. 2024. Introducing the NUATEI Consortium: A Mexican Research Program for the Identification of Natural and Synthetic Antimicrobial Compounds for Prevalent Infectious Diseases. Pharmaceuticals 2024, 17(7), 957; https://doi.org/10.3390/ph17070957. ISSN: 1424-8247. E-ISSN: 2076-3417.

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx