Las proteínas son entidades dinámicas con cambios estructurales esenciales para llevar a cabo su función. Mi línea de investigación involucra el estudio de la relación entre la estructura la dinámica y la función de proteínas, utilizando metodologías de biofísica

Utilizamos metodologías de simulación molecular multiescala para determinar las propiedades estructurales y el ensamble conformacional de proteínas involucradas en enfermedades neurodegenerativas y causadas por el mal plegamiento.

Publicaciones

1) SL Chin, Q Lu, EL Dane, L Dominguez, CJ McKnight, JE Straub, MW Grinstaff. Combined Molecular Dynamics Simulations and Experimental Studies of the Structure and Dynamics of Poly-Amido-Saccharides. JACS, 138.20 (2016): 6532-6540. FI 13.04

2) J Pacheco, L Dominguez, A Bohórquez-Hernández, A Asanov, L Vaca. A cholesterol-binding domain in STIM1 modulates STIM1-Orai1 physical and functional interactions.
Nature Scientific Reports, (2016) 6: 29634. FI 5.57

3) L Dominguez, LS Foster, JE Straub, D. Thirumalai. Impact of membrane lipid composition on the structure and stability of homodimers of the transmembrane domain of Amyloid Precursor Protein.
PNAS (2016) : 201606482. FI 9.43

4) A Panahi, A Bandara., G Pantelopulos, L Dominguez, JE Straub. Specific Binding of Cholesterol to C99. Domain of Amyloid Precursor Protein Depends Critically on Charge State of Protein.
Journal of Physical Chemistry Letters (2016). FI 8.53

5) S Viswanath, L Dominguez, LS Foster, JE Straub, R Elber. Extension of a protein docking algorithm to membranes and applications to amyloid precursor protein dimerization.
Proteins, 83.12 (2015): 2170-2185. FI 2.49

6) Role of Charge and Solvation in the Structure and Dynamics of Alanine-Rich Peptide AKA2 in AOT Reverse Micelles. AV Martinez, E Małolepsza, L Domínguez, Q Lu, JE Straub
The Journal of Physical Chemistry B 119 (29), 9084-9090, 2014. FI 3.18

7) Structural heterogeneity in transmembrane Amyloid Precursor Protein homodimer is a consequence of environmental selection, L. Dominguez, L. Foster, SC. Meredith, JE. Straub and D. Thirumalai.
JACS, 136(27), 9619-9626, 2014. FI. 13.04

8) Transmembrane fragment structures of Amyloid Precursor Protein depend on membrane surface curvature. L. Dominguez, SC. Meredith, JE. Straub and D. Thirumalai.
JACS, Communications. 136(3), 854-857, 2014. FI. 13.04

9) El Premio Nobel de Química 2013 para Químicos Computacionales.
L. Dominguez and C. Amador.
Revista de Educación Química. Volume XXV, 82-85, 2014

10) How catalase recognizes H2O2 in a sea of water.
L. Dominguez, A. Sosa-Peinado, W. Hansberg.
Proteins: Structure, Function, and Bioinformatics, 82.1, 45-46, 2014. FI. 2.49

11) Probing the structure and dynamics of confined water in AOT reverse micelles.
A.V. Martinez, L. Dominguez, E. Malolepsza, A. Moser, Z. Ziegler, and JE. Straub
Journal Physical Chemistry B, 117, 7345-7351, 2013. FI. 3.187

12) Fungal catalases: function, phylogenetic origin and structure.
R. Salas-Lizana, W. Hansberg, L. Dominguez.
Review Archives of Biochemistry and Biophysics, 525(2), 170-180, 2012. FI. 3.07

13) Protein folding in a reverse micelle environment: The role of confinement and dehydration.
AV. Martinez, SC. DeSensi, L. Dominguez, E. Rivera, and JE. Straub.
Journal of Chemical Physics, 134 (5), 055107, 2011. FI. 2.89

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx