Tutores

Campos de conocimiento

Mi línea de investigación se dedica al estudio de una población de células del sistema inmunitario denominados linfocitos T CD8+, los cuales tienen la capacidad de reconocer y eliminar células malignas; no obstante, los tumores pueden evitar la acción de estas células mediante diferentes maneras. Recientemente, nuestras investigaciones se enfocan en el estudio del metabolismo de las T CD8+ y las alteraciones que presentan en su metabolismo celular y mitocondrial que les impiden eliminar a los tumores malignos de pulmón. Lo anterior con la idea de buscar blancos terapéuticos a nivel bioquímico que puedan servir para incrementar la actividad citotóxica del linfocito T CD8+.

Prado-Garcia H, Romero-Garcia S, Castro-Flores DA, Rumbo-Nava U. Deficient glucose uptake is linked to impaired Glut1 expression upon CD3/CD28 stimulation in memory T cells from pleural effusions secondary to lung cancer. Scand J Immunol. 2019 Jul 3:e12802. doi: 10.1111/sji.12802. (Índice de impacto: 2.563)
García-Quiroz J, González-González ME, Díaz L, Ordaz-Rosado D, Segovia-Mendoza M, Prado-García H, Larrea F, García-Becerra R. ASTEMIZOLE, AN INHIBITOR OF ETHER-À-GO-GO-1 POTASSIUM CHANNEL, INCREASES THE ACTIVITY OF THE TYROSINE KINASE INHIBITOR GEFITINIB IN BREAST CANCER CELLS. Rev Invest Clin. 2019;71(3):186-194. doi: 10.24875/RIC.18002840. (Índice de impacto: 1.513)
Romero-Garcia S, Prado-Garcia H. Mitochondrial calcium: Transport and modulation of cellular processes in homeostasis and cancer (Review). Int J Oncol. 2019;54(4):1155-1167. doi: 10.3892/ijo.2019.4696. (Índice de impacto: 3.571)
Segovia-Mendoza M, Díaz L, Prado-Garcia H, Reginato MJ, Larrea F, García-Becerra R. The addition of calcitriol or its synthetic analog EB1089 to lapatinib and neratinib treatment inhibits cell growth and promotes apoptosis in breast cancer cells. Am J Cancer Res. 2017 Jul 1;7(7):1486-1500. eCollection 2017. (Índice de impacto: 4.737)
Prado-Garcia H, Sánchez-García FJ. Editorial: Immuno-metabolism in tumor microenvironment Front Immunol. 2017 8:374 doi: 10.3389/fimmu.2017.00374 (Índice de impacto: 4.716)
Prado-Garcia H, Romero-Garcia S, Puerto-Aquino A, Rumbo-Nava U. The PD-L1/PD-1 pathway promotes dysfunction, but not "exhaustion", in tumor-responding T cells from pleural effusions in lung cancer patients. Cancer Immunol Immunother. 2017 66(6):765-776. doi: 10.1007/s00262-017-1979-x. (Índice de impacto: 4.900)
Coronado-Cerda EE, Franco-Molina MA, Mendoza-Gamboa E, Prado-García H, Rivera-Morales LG, Zapata-Benavides P, Rodríguez-Salazar MC, Caballero-Hernandez D, Tamez-Guerra RS, Rodríguez-Padilla C. In Vivo Chemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil. J Immunol Res, 2016;2016: 6942321. doi:10.1155/2016/6942321 (Índice de impacto: 3.330)
Romero-Garcia S, Moreno-Altamirano MM, Prado-Garcia H, Sánchez-García FJ. Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance. Front Immunol. 2016 7:52. doi:10.3389/fimmu.2016.00052. (Índice de impacto: 4.716)
Islas-Vazquez L, Prado-Garcia H, Aguilar-Cazares D, Meneses-Flores M, Galicia-Velasco M, Romero-Garcia S, Camacho-Mendoza C, Lopez-Gonzalez JS. LAP TGF-Beta Subset of CD4(+)CD25(+)CD127(-) Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients. Biomed Res Int. 2015;2015:430943. doi: 10.1155/2015/430943. (Índice de impacto: 2.410)
Prado-Garcia H, Romero-Garcia S, Rumbo-Nava U, Lopez-Gonzalez JS. Predominance of Th17 Over Regulatory T-Cells in Pleural Effusions of Patients with Lung Cancer Implicates A Proinflammatory Profile. Anticancer Res. (2015) 35:1529-35 (Índice de impacto: 1.935)
Segovia-Mendoza M, Díaz L, González-González ME, Martínez-Reza I,García-Quiroz J, Prado-Garcia H, Ibarra-Sánchez MJ, Esparza-López J, Larrea F, García-Becerra R. Calcitriol and its analogues enhance the antiproliferative activity of gefitinib in breast cancer cells. J Steroid Biochem Mol Biol. 2015 148:122-131. (Índice de impacto: 3.785)
Prado-Garcia Heriberto, Romero-Garcia Susana, Lopez-Gonzalez Jose Sullivan. The Role of Exhaustion in Tumor-Induced T Cell Dysfunction in Cancer. In Cancer Immunology, A Translational Medicine Context. Springer 2015. pp 61-75
Mariana Segovia-Mendoza, Rafael Jurado, Roser Mir, Luis Alberto Medina, Heriberto Prado-Garcia and Patricia Garcia-Lopez. Antihormonal agents as a strategy to improve the effect of chemo-radiation in cervical cancer: in vitro and in vivo study. BMC Cancer. (2015) 27;15(1):21 (Índice de impacto: 2.933)
Prado-Garcia H, Romero-Garcia S, Lopez-Gonzalez JS. Activated T cells, but not lung tumor cells, express fas ligand. Ann Thorac Surg. (2014) 97:379-80. (Índice de impacto: 3.919)
Romero-Garcia S, Prado-Garcia H, Lopez-Gonzalez JS. Transcriptional analysis of hnRNPA0, A1, A2, B1, and A3 in lung cancer cell lines in response to acidosis, hypoxia, and serum deprivation conditions. Exp Lung Res. (2014) 40:12-14 (Índice de impacto: 1.568)
Aguilar-Cazares D, Meneses-Flores M, Prado-Garcia H, Islas-Vazquez L, Rojo-Leon V, Romero-Garcia S, Rivera-Rosales RM, Lopez-Gonzalez JS. Relationship of Dendritic Cell Density, HMGB1 Expression, and Tumor-infiltrating Lymphocytes in Non-Small Cell Lung Carcinomas. Applied Immunohistochem Mol Morphol. (2014) 22:(105-113) (Índice de impacto: 1.863)