Mi principal línea es la búsqueda de nuevas alternativas contra la tuberculosis mediante el uso del sistema de evaluación de viabilidad REMA (resazurin microtiter assay), la toxicidad celular en células Vero y Jurkat por MTT.
Modelo de granuloma tuberculoso humano in vitro, aspectos inmunológicos y estudio de la relación hospedero-parásito.
Efecto de los metabolitos de ciclo de Krebs en el granuloma inducido por BCG.
Estudio y caracterización de las células espumosas en la tuberculosis.

Publicaciones

Guzmán-Gutiérrez SL, Nieto-Camacho A, Castillo-Arellano JI, Huerta-Salazar E, Hernández-Pasteur G, Silva-Miranda M, Argüello-Nájera O, Sepúlveda-Robles O, Espitia CI9, Reyes-Chilpa R.Mexican Propolis: A Source of Antioxidants and Anti-Inflammatory Compounds, and Isolation of a Novel Chalcone and ε-Caprolactone Derivative. Molecules. 2018 Feb 6;23(2). pii: E334. doi: 10.3390/molecules23020334. F.I: 3.098.

Trenado-Uribe M*, Silva-Miranda M*. Rivero-Cruz JF, Rodríguez-Peña K, Espitia-Pinzón CI, Rodríguez-Sanoja R, Sánchez S.Antimycobacterial activity of an anthracycline produced by an endophyte isolated from Amphipterygium adstringens. Mol Biol Rep. 2018 Dec;45(6):2563-2570. doi: 10.1007/s11033-018-4424-0. Epub 2018 Oct 11. *equal contribution FI: 1.889

Roberto Martinez, Gladys J Nieves Zamudio, Gustavo Pretelin-Castillo, Rubén O Torres-Ochoa, José L Medina Franco, Clara I Espitia Pinzon, Mayra Silva Miranda, Eugenio Hernández and Blanca Alanis-Garza. Synthesis and antitubercular activity of new N-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]- (nitroheteroaryl)carboxamides. Heterocycl Commun. 2019, 25 (1): 1-8. https://doi.org/10/10.1515/hc-2019-0007. FI:0.7

Sepúlveda-Robles O, Espinoza-Gutiérrez B, Gomez-Verjan JC, Guzmán-Gutiérrez SL, De Ita M, Silva-Miranda M, Espitia-Pinzón CI, Fernández-Ramírez F, Herrera-Salazar A, Mata-Rocha M, Ortega-Hernández A, Reyes-Chilpa R. Trypanocidal and toxicological assessment in vitro and in silico of three sesquiterpene lactones from Asteraceae plant species.. Food Chem Toxicol. 2019 Mar;125:55-61. doi: 10.1016/j.fct.2018.12.023. Epub 2018 Dec 18. FI: 3.977

Echeverría-Valencia G, Silva-Miranda M, Ekaza, E, Vallecillo, A.J. Sada-Ovalle I. Altare F, Espitia C. Interaction of mycobacteria with Plasmin(ogen) affects phagocytosis and granuloma development. TuberculosisVolume 117, July 2019, Pages 36-44. F.I:2.790.

Martínez, Roberto; Espitia-Pinzon, Clara I.; Silva Miranda, Mayra; Chávez-Santos, Rosa María; Pretelin-Castillo, Gustavo; Ramos_Orea, Aldahir; Hernández-Báez, Ángela M; Cotlame-Pérez, Sandra. "Synthesis and antituberculosis activity of new acylthiosemicarbazides designed by structural modification." Drug Dev Res 2020 May;81(3):350-355.doi: 10.1002/ddr.21626. F.I: 1.742

Ortega P, Silva Miranda M, Torres-Larios A, Campos-Chavez E, Kees CLCM Franken, Ottenhoff, Ivanyi J, Espitia C. Selection of a Single Domain Antibody, Specific for an HLA-Bound Epitope of the Mycobacterial Ag85B Antigen. Front. Immunol., 02 October 2020 | https://doi.org/10.3389/fimmu.2020.577815 F.I 5.085

Silvia Laura Guzmán-Gutiérrez # , Mayra Silva-Miranda # , Felix Krengel , Elizabeth Huerta-Salazar , Mayra León-Santiago , Jessica Karina Díaz-Cantón , Clara Espitia Pinzón , Ricardo Reyes-Chilpa . Antimycobacterial Activity of Alkaloids and Extracts From Tabernaemontana Alba and T. Arborea.Plan Med. 2020 May 18. doi: 10.1055/a-1177-3691. # equal contribution. F.I:2.74

Rahul Sharma , Pushpendra Singh , Rajiv C McCoy , Shannon M Lenz , Kelly Donovan , Maria T Ochoa , Iris Estrada-Garcia , Mayra Silva-Miranda , Fermin Jurado-Santa Cruz , Marivic F Balagon , Barbara Stryjewska , David M Scollard , Maria T Pena , Ramanuj Lahiri , Diana L Williams , Richard W Truman , Linda B Adams . Isolation of Mycobacterium Lepromatosis and Development of Molecular Diagnostic Assays to Distinguish M. Leprae and M. Lepromatosis Clin Infect Dis . 2019 Nov 16;ciz1121. doi: 10.1093/cid/ciz1121. F.I: 9.055

Pretelín-Castillo G, Silva Miranda M, Espitia C, Chávez-Santos RM, Suárez-Castro A, Chacón-García L, Aguayo-Ortiz R, Martinez R. (2Z)-3-Hydroxy-3-(4-R-Phenyl)-Prop-2-Enedithioic Acids as New Antituberculosis Compounds. Infect Drug Resist. 2021 Oct 20;14:4323-4332. doi: 10.2147/IDR.S328132. eCollection 2021. PMID: 34707377 F.I: 4.033

Parada C, Neri-Badillo IC, Vallecillo AJ, Segura E, Silva-Miranda M, Guzmán-Gutiérrez SL, Ortega PA, Coronado-Aceves EW, Cancino-Villeda L, Torres-Larios A, Aceves Sánchez MJ, Flores Valdez MA, Espitia C. New Insights into the Methylation of Mycobacterium tuberculosis Heparin Binding Hemagglutinin Adhesin Expressed in Rhodococcus erythropolis. Pathogens. 2021 Sep 4;10(9):1139. doi: 10.3390/pathogens10091139. PMID: 34578171 F.I: 3.492

Ramos-Orea A, Ramírez-Apan T, Chávez-Santos RM, Aguayo-Ortiz R, Espitia C, Silva Miranda M, Torres-Ochoa RO, Martínez R. Total syntheses and antiproliferative activities of prenostodione and its analogues. . Org Biomol Chem. 2021 Oct 6;19(38):8272-8280. doi: 10.1039/d1ob00897h. PMID: 34518856 F.I : 3.876

Carrero JC, Curay-Herrera V, Chacón-Niño L, Krengel F, Guzmán-Gutiérrez SL, Silva-Miranda M, González-Ramírez LC, Bobes-Ruíz R, Espitia CI, Reyes-Chilpa R, Laclette JP. Potent anti-amoebic effects of Ibogaine, Voacangine and the root bark alkaloid fraction of Tabernaemontana arborea. Planta Med. 2022 Mar 25. doi: 10.1055/a-1809-1157. Online ahead of print. PMID: 35338475 F.I: 3.352

Castañeda-Fernandez C, Chávez-Santos RM, Silva-Miranda M, Espitia-Pinzón C, Martínez R, Kozina A Optimization of Rifampicin Encapsulation in PLGA Polymeric Reservoirs. . Int J Pharm. 2022 May 20:121844. doi: 10.1016/j.ijpharm.2022.121844. Online ahead of print. PMID: 35605890 F.I: 5.875

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx