Contacto
Campos de conocimiento
Biofísica
Biología Molecular y Celular de Microorganismos, Plantas y Animales
Bioquímica
Genética y Fisiología Celular
Líneas de investigación
- Efecto de citocinas sobre la susceptibilidad de linfocitos T en reposo a la infección por el VIH-1.
- Fusión celular inducida por el VIH-1.
- Actividad de nuevos compuestos contra infecciones virales (VIH-1, influenza y SARS-Cov-2).
- Modelos matemáticos de la función de los linfocitos T CD4.
- Mecanismo de entrada del SARS-Cov-2 a sus células blanco. Pseudovirus.
- Respuesta immune inducida por vacunas al SARS-CoV-2.
Publicaciones
1. Onasis Vicente-Fermín, Edgar Zenteno, Ivan Ramos-Martínez, Clara Espitia-Pinzón, José Ivan Sánchez-Betancourt, Leonor Huerta (author responsable).
Effect of dexamethasone on the expression of the α2,3 and α2,6 sialic acid in epithelial cell lines.
Pathogens. 2022 Dec 12;11(12):1518. doi: 10.3390/pathogens11121518.
(FI: 4.531)
2. Isabel Ruelas-Galindo, Leonor Huerta (autor responsable).
Soluble factors from TLR4- or TCR-activated cells contribute to stability of the resting phenotype and increase the expression of CXCR4 of human memory CD4 T cells.
Immunologic Research. 2022 Dec 21. doi: 10.1007/s12026-022-09345-1.
(FI: 4.505)
3. David Martínez-Méndez, Leonor Huerta (autor responsable), Carlos Villarreal.
Modeling the effect of microenvironmental nutrient conditions and hypoxia on T cell differentiation.
Frontiers in Immunology, 13. 2022.
DOI=10.3389/fimmu.2022.962175. 1 cita.
(FI: 8.786)
4. Jacquelynne Cervantes-Torres, Sergio Rosales-Mendoza, Carlos Cabello, Laura Montero, Juan Hernandez-Aceves, Guillermo Granados, Arturo Calderón-Gallegos, Francisco Zúñiga-Flores, Mirna Ruiz-Rivera, Julio César Abarca-Magaña, Sandra Ortega-Francisco, Roxana Olguin-Alor, Georgina Díaz, Filipo Paczka-Garcia, Rubí Zavala-Gaytan, Ricardo Vázquez-Ramírez, Dolores Adriana Ayón-Nuñez, Julio César Carrero, Diana Rios, Mariana Jasso-Ramírez, Rebeca Vázquez-Hernández, David Venegas, Daniel Garzón, Laura Cobos, René Segura-Velázquez, Nelly Villalobos, Gabriela Meneses, Joaquín Zúñiga, Gerardo Gamba, Graciela Cárdenas, Marisela Hernández, Michael E. Parkhouse, Marta C. Romano, Luis Alonso Herrera, Raúl J. Bobes, Mayra Pérez-Tapia, Leonor Huerta, Nora Fierro, Isabel Gracia, Gloria Soldevilla, Gladis Fragoso, Francisco Suárez-Güemes, Juan P. Laclette, Edda Sciutto.
Towards the development of an epitope-focused vaccine for SARS-CoV-2.
Vaccine, 2022, 40(45), 6489-6498
DOI: 10.1016/j.vaccine.2022.09.059.
(FI: 4.169)
5. Dolores Adriana Ayón-Núñez, Jacquelynne Cervantes-Torres, Carlos Cabello-Gutiérrez, Sergio Rosales-Mendoza, Diana Rios-Valencia, Leonor Huerta, Raúl J. Bobes, Julio César Carrero, René Segura-Velázquez, Nora Alma Fierro, Marisela Hernández, Joaquín Zúñiga-Ramos, Gerardo Gamba, Graciela Cárdenas, Emanuel Frías-Jiménez, Luis Alonso Herrera, Gladis Fragoso, Edda Sciutto, Francisco Suárez-Güemes, Juan Pedro Laclette.
An RBD-based diagnostic method useful for the surveillance of protective immunity against SARS-CoV-2 in the population.
Diagnostics, 2022, 12(7), 1629.
DOI: 10.3390/diagnostics12071629.
(FI: 3.992)
6. Cárdenas G, Chávez-Canales M, Espinosa AM, Jordán-Ríos A, Malagon DA, Murillo MFM, Araujo LVT, Campos RLB, Wong-Chew RM, González LER, Cresencio KI, Velázquez EG, de la Cerda MR, Leyva Y, Hernández-Ruiz J, Hernández-Medel ML, León-Hernández M, Quero KM, Monciváis AS, Díaz SH, Martínez IRZ, Martínez-Cuazitl A, Salazar INM, Sarmiento EB, Peña AF, Hernández PS, Reynoso RIA, Reyes DM, Del Río Ambriz LR, Bonilla RAA, Cruz J, Huerta L, Fierro NA, Hernández M, Pérez-Tapia M, Meneses G, Espíndola-Arriaga E, Rosas G, Chinney A, Mendoza SR, Hernández-Aceves JA, Cervantes-Torres J, Rodríguez AF, Alor RO, Francisco SO, Salazar EA, Besedovsky H, Romano MC, Bobes RJ, Jung H, Soldevila G, López-Alvarenga J, Fragoso G, Laclette JP, Sciutto E.
Intranasal dexamethasone: a new clinical trial for the control of inflammation and neuroinflammation in COVID-19 patients.
Trials, 2022, 23, 148-151.
DOI: 10.1186/s13063-022-06075-5.
(FI: 2.279).
7. David Martínez-Méndez, Luis Mendoza, Carlos Villarreal, Leonor Huerta (autor responsable).
Continuous modeling of T CD4 cell activation and function.
Frontiers in Immunology, 2021, 12: 4424-4439.
DOI: 10.3389/fimmu.2021.743559. 1 cita.
(FI: 8.786).
8. Mirna Berenice Ruiz-Rivera, Guillermo Gómez-Icazbalceta, Leonor Huerta (autor responsable).
Host-membrane proteins in the HIV-1-induced membrane fusion; role in pathogenesis and therapeutic potential of autoantibodies.
Current Opinion in Pharmacology, 2021, 60:241-248.
DOI: 10.1016/j.coph.2021.07.005.
(FI: 4.768).
9. Karen Lizbeh Reyes-Barrera, Ruth Elena Soria-Guerra, Rogelio López-Martínez, Leonor Huerta, Nohemí Salinas-Jazmín, Carlos Cabello-Gutiérrez, Ángel Gabriel Alpuche-Solís.
The entry blocker peptide produced in Chlamydomonas reinhardtii inhibits influenza viral replication in vitro.
Frontiers in Plant Science, 2021, 12: 641420.
DOI: 10.3389/fpls.2021.641420. 3 citas.
(FI: 6.676).
10. Juan Voutssas-Lara, Jacquelynne Cervantes-Torres, Marisela Hernández, Raúl J. Bobes, Edmundo Lamoyi, Ricardo A. Vázquez-Ramírez, Luis Mendoza, Karen L. Reyes-Barrera, Rogelio López-Martínez, Angel G. Alpuche-Solís, Sergio Rosales-Mendoza, Leonor Huerta, Gladis Fragoso, Edda Sciutto.
Influence of adjuvants on the amount, specificity and functional activity of antibody response to human influenza vaccine in mice.
Molecular Immunology, 2021, 135: 398-407.
DOI: 10.1016/j.molimm.2021.05.003. 1 cita.
(FI: 4.174).
11. Leonor Huerta (autor responsable).
Editorial: Anti-infective 2020: HIV, from pathogenesis to treatment.
Current Opinion in Pharmacology, 2020, 54: x-xii.
DOI: 10.1016/j.coph.2020.12.001. 1 cita.
(FI 4.768).
12. Martínez-Méndez David, Villarreal Carlos, Mendoza Luis, Huerta Leonor (autor responsable) .
An integrative network modeling approach to T CD4 cell activation.
Frontiers in Physiology, 2020, 11, article 380: 1-14.
DOI: 10.3389/fphys.2020.00380. 11 citas
(FI 4.755).
13. Julio C. Abarca, Leonor Huerta, Nora A. Fierro.
Antiretroviral Therapies for Human Immunodeficiency Virus and Liver Disease: Challenges and opportunities.
Annals of Hepatology 2020, 19(2):121-122.
DOI: 10.1016/j.aohep.2020.02.004. 2 citas.
(FI: 3.388).
14. Leonor Huerta, Julio Y. Anaya-Covarrubias, Nora A. Fierro.
Human immunodeficiency virus and the liver: The impact of coinfection with hepatotropic viruses.
Annals of Hepatology 2019, 18(2):285-286.
DOI: 10.1016/j.aohep.2019.03.002. 3 citas.
(FI: 3.388).
15. Mirna Berenice Ruiz-Rivera, Guillermo Gómez-Icazbalceta, Marcela Vélez-Alavez, Mónica Viveros-Rogel, Santiago Pérez-Patrigeon, Edmundo Lamoyi, Luis Llorente, Carlos A Núñez-Álvarez, Leonor Huerta (autor responsable).
Inhibition of the HIV-1 envelope-dependent membrane fusion by serum anti-lymphocyte autoantibodies associates with low plasma viral load.
Immunology Letters 2019, 211:33-40.
DOI: 10.1016/j.imlet.2019.05.002. 1 cita
(FI: 4.230).
16. Mariana Esther Martínez-Sánchez, Leonor Huerta, Elena R. Álvarez-Buylla, Carlos Villarreal.
Role of cytokine combinations on CD4+ T cell differentiation, partial polarization, and plasticity: continuous network modeling approach.
Frontiers in Physiology 2018, 9:877.
DOI: 10.3389/fphys.2018.00877. 35 citas
(FI 4.755).
