- Efecto de citocinas sobre la susceptibilidad de linfocitos T en reposo a la infección por el VIH-1.
- Fusión celular inducida por el VIH-1.
- Actividad de nuevos compuestos contra infecciones virales (VIH-1, influenza y SARS-Cov-2).
- Modelos matemáticos de la función de los linfocitos T CD4.
- Mecanismo de entrada del SARS-Cov-2 a sus células blanco. Pseudovirus.
- Respuesta immune inducida por vacunas al SARS-CoV-2.

Publicaciones

1. Martínez-Méndez David , Villarreal Carlos , Huerta Leonor.
Modeling uncertainty: the impact of noise in T cell differentiation
Frontiers in Systems Biology, 4, 2024.
Doi: 10.3389/fsysb.2024.1412931.
Nueva revista de la editorial Frontiers. Sin FI.

2. Carrero, J.C.; Espinoza, B.; Huerta, L.; Silva-Miranda, M.; Guzmán-Gutierrez, S.-L.; Dorazco-González, A.; Reyes-Chilpa, R.; Espitia, C.; Sánchez, S.
Introducing the NUATEI Consortium: A Mexican Research Program for the Identification of Natural and Synthetic Antimicrobial Compounds for Prevalent Infectious Diseases.
Pharmaceuticals 2024, 17, 957.
https://doi.org/10.3390/ph17070957.
(FI:4.3).

3. Jacquelynne Cervantes-Torres, Carlos Cabello-Gutiérrez, Dolores-Adriana Ayón-Núñez, Gloria Soldevila, Roxana Olguin-Alor, Georgina Diaz, Gonzalo Acero, René Segura-Velázquez, Leonor Huerta, Isabel Gracia-Mora, Laura Cobos, Mayra Pérez-Tapia, Juan C Almagro, Francisco Suárez-Güemes, Raúl J Bobes, Gladis Fragoso, Edda Sciutto, Juan Pedro Laclette.
Caveats of chimpanzee ChAdOx1 adenovirus-vectored vaccines to boost anti-SARS-CoV-2 protective immunity in mice
Applied Microbiology and Biotechnology 2024, 108 (1), 179.
doi.org/10.1007/s00253-023-12927-0.
(FI: 3.9).

4. Graciela Cárdenas, María Chávez-Canales, Ana María Espinosa, Antonio Jordán-Ríos, Daniel Anica Malagon, Manlio Fabio Márquez Murillo, Laura Victoria Torres Araujo, Ricardo Leopoldo Barajas Campos, Rosa María Wong-Chew, Luis Esteban Ramirez González, Karent Ibet Cresencio, Enrique García Velázquez, Mariana Rodriguez de la Cerda, Yoana Leyva, Joselin Hernández-Ruiz, María Luisa Hernández-Medel, Mireya León-Hernández, Karen Medina Quero, Anahí Sánchez Monciváis, Eduardo Beltrán Sarmiento, Rafael Ignacio Aguilar Reynoso, Daniela Murillo Reyes, Luis Rodrigo del Río Ambriz, Juan Salvador García Hernández, Jocelyn Cruz, Sergio Iván Valdés Ferrer, Leonor Huerta, Nora Alma Fierro, Marisela Hernández, Mayra Pérez-Tapia, Gabriela Meneses, Gabriela Rosas, Juan Alberto Hernández-Aceves, Jaquelynne Cervantes-Torres, Ricardo A Valdez, Anai Fuentes Rodríguez, Erick Espíndola-Arriaga, Mauricio Ortiz, Evelyn Alvarez Salazar, Carlos Castellanos Barba, Hugo Besedovsky, Marta C Romano, Helgi Jung, Raúl J Bobes, Gloria Soldevila, Juan C López-Alvarenga, Gladis Fragoso, Juan Pedro Laclette, Edda Sciutto.
Intranasal Versus Intravenous Dexamethasone to Treat Hospitalized COVID-19 Patients: A Randomized Multicenter Clinical Trial.
Archives of Medical Research 2024, 55 (2), 102960.
doi.org/10.1016/j.arcmed.2024.102960.
(FI: 4.7).

5. Isabel Ruelas-Galindo, Leonor Huerta (autor responsable).
Soluble factors from TLR4- or TCR-activated cells contribute to stability of the resting phenotype and increase the expression of CXCR4 of human memory CD4 T cells.
Immunologic Research 2023.
doi: 10.1007/s12026-022-09345-1.
(FI: 3.3)

6. Onasis Vicente-Fermín, Edgar Zenteno, Ivan Ramos-Martínez, Clara Espitia-Pinzón, José Ivan Sánchez-Betancourt, Leonor Huerta (author responsable).
Effect of dexamethasone on the expression of the α2,3 and α2,6 sialic acid in epithelial cell lines.
Pathogens. 2022 Dec 12;11(12):1518.
doi: 10.3390/pathogens11121518.
(FI: 3.3)

7. David Martínez-Méndez, Leonor Huerta (autor responsable), Carlos Villarreal.
Modeling the effect of microenvironmental nutrient conditions and hypoxia on T cell differentiation.
Frontiers in Immunology, 13. 2022.
DOI=10.3389/fimmu.2022.962175. 1 cita.
(FI: 5.7)

8. Jacquelynne Cervantes-Torres, Sergio Rosales-Mendoza, Carlos Cabello, Laura Montero, Juan Hernandez-Aceves, Guillermo Granados, Arturo Calderón-Gallegos, Francisco Zúñiga-Flores, Mirna Ruiz-Rivera, Julio César Abarca-Magaña, Sandra Ortega-Francisco, Roxana Olguin-Alor, Georgina Díaz, Filipo Paczka-Garcia, Rubí Zavala-Gaytan, Ricardo Vázquez-Ramírez, Dolores Adriana Ayón-Nuñez, Julio César Carrero, Diana Rios, Mariana Jasso-Ramírez, Rebeca Vázquez-Hernández, David Venegas, Daniel Garzón, Laura Cobos, René Segura-Velázquez, Nelly Villalobos, Gabriela Meneses, Joaquín Zúñiga, Gerardo Gamba, Graciela Cárdenas, Marisela Hernández, Michael E. Parkhouse, Marta C. Romano, Luis Alonso Herrera, Raúl J. Bobes, Mayra Pérez-Tapia, Leonor Huerta, Nora Fierro, Isabel Gracia, Gloria Soldevilla, Gladis Fragoso, Francisco Suárez-Güemes, Juan P. Laclette, Edda Sciutto.
Towards the development of an epitope-focused vaccine for SARS-CoV-2.
Vaccine, 2022, 40(45), 6489-6498
DOI: 10.1016/j.vaccine.2022.09.059.
(FI: 4.5)

9. Dolores Adriana Ayón-Núñez, Jacquelynne Cervantes-Torres, Carlos Cabello-Gutiérrez, Sergio Rosales-Mendoza, Diana Rios-Valencia, Leonor Huerta, Raúl J. Bobes, Julio César Carrero, René Segura-Velázquez, Nora Alma Fierro, Marisela Hernández, Joaquín Zúñiga-Ramos, Gerardo Gamba, Graciela Cárdenas, Emanuel Frías-Jiménez, Luis Alonso Herrera, Gladis Fragoso, Edda Sciutto, Francisco Suárez-Güemes, Juan Pedro Laclette.
An RBD-based diagnostic method useful for the surveillance of protective immunity against SARS-CoV-2 in the population.
Diagnostics, 2022, 12(7), 1629.
DOI: 10.3390/diagnostics12071629.
(FI: 3)

10. Cárdenas G, Chávez-Canales M, Espinosa AM, Jordán-Ríos A, Malagon DA, Murillo MFM, Araujo LVT, Campos RLB, Wong-Chew RM, González LER, Cresencio KI, Velázquez EG, de la Cerda MR, Leyva Y, Hernández-Ruiz J, Hernández-Medel ML, León-Hernández M, Quero KM, Monciváis AS, Díaz SH, Martínez IRZ, Martínez-Cuazitl A, Salazar INM, Sarmiento EB, Peña AF, Hernández PS, Reynoso RIA, Reyes DM, Del Río Ambriz LR, Bonilla RAA, Cruz J, Huerta L, Fierro NA, Hernández M, Pérez-Tapia M, Meneses G, Espíndola-Arriaga E, Rosas G, Chinney A, Mendoza SR, Hernández-Aceves JA, Cervantes-Torres J, Rodríguez AF, Alor RO, Francisco SO, Salazar EA, Besedovsky H, Romano MC, Bobes RJ, Jung H, Soldevila G, López-Alvarenga J, Fragoso G, Laclette JP, Sciutto E.
Intranasal dexamethasone: a new clinical trial for the control of inflammation and neuroinflammation in COVID-19 patients.
Trials, 2022, 23, 148-151.
DOI: 10.1186/s13063-022-06075-5.
(FI: 2).

11. David Martínez-Méndez, Luis Mendoza, Carlos Villarreal, Leonor Huerta (autor responsable).
Continuous modeling of T CD4 cell activation and function.
Frontiers in Immunology, 2021, 12: 4424-4439.
DOI: 10.3389/fimmu.2021.743559. 1 cita.
(FI: 5.7).

12. Mirna Berenice Ruiz-Rivera, Guillermo Gómez-Icazbalceta, Leonor Huerta (autor responsable).
Host-membrane proteins in the HIV-1-induced membrane fusion; role in pathogenesis and therapeutic potential of autoantibodies.
Current Opinion in Pharmacology, 2021, 60:241-248.
DOI: 10.1016/j.coph.2021.07.005.
(FI: 4).

13. Karen Lizbeh Reyes-Barrera, Ruth Elena Soria-Guerra, Rogelio López-Martínez, Leonor Huerta, Nohemí Salinas-Jazmín, Carlos Cabello-Gutiérrez, Ángel Gabriel Alpuche-Solís.
The entry blocker peptide produced in Chlamydomonas reinhardtii inhibits influenza viral replication in vitro.
Frontiers in Plant Science, 2021, 12: 641420.
DOI: 10.3389/fpls.2021.641420. 3 citas.
(FI: 4.1).

14. Juan Voutssas-Lara, Jacquelynne Cervantes-Torres, Marisela Hernández, Raúl J. Bobes, Edmundo Lamoyi, Ricardo A. Vázquez-Ramírez, Luis Mendoza, Karen L. Reyes-Barrera, Rogelio López-Martínez, Angel G. Alpuche-Solís, Sergio Rosales-Mendoza, Leonor Huerta, Gladis Fragoso, Edda Sciutto.
Influence of adjuvants on the amount, specificity and functional activity of antibody response to human influenza vaccine in mice.
Molecular Immunology, 2021, 135: 398-407.
DOI: 10.1016/j.molimm.2021.05.003. 1 cita.
(FI: 3.2).

15. Leonor Huerta (autor responsable).
Editorial: Anti-infective 2020: HIV, from pathogenesis to treatment.
Current Opinion in Pharmacology, 2020, 54: x-xii.
DOI: 10.1016/j.coph.2020.12.001. 1 cita.
(FI: 4).

16. Martínez-Méndez David, Villarreal Carlos, Mendoza Luis, Huerta Leonor (autor responsable) .
An integrative network modeling approach to T CD4 cell activation.
Frontiers in Physiology, 2020, 11, article 380: 1-14.
DOI: 10.3389/fphys.2020.00380. 11 citas
(FI 3.2).

17. Julio C. Abarca, Leonor Huerta, Nora A. Fierro.
Antiretroviral Therapies for Human Immunodeficiency Virus and Liver Disease: Challenges and opportunities.
Annals of Hepatology 2020, 19(2):121-122.
DOI: 10.1016/j.aohep.2020.02.004. 2 citas.
(FI: 3.7).

18. Leonor Huerta, Julio Y. Anaya-Covarrubias, Nora A. Fierro.
Human immunodeficiency virus and the liver: The impact of coinfection with hepatotropic viruses.
Annals of Hepatology 2019, 18(2):285-286.
DOI: 10.1016/j.aohep.2019.03.002. 3 citas.
(FI: 3.7).

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx