Contacto
Campos de conocimiento
Biofísica
Bioquímica
Reconocimiento Molecular y Bioestructura
Líneas de investigación
Formación de complejos de proteína. Plegamiento de proteína. Interacción proteína-proteína y proteína-ligando
Publicaciones
38. Gómez-Velasco, H.†, Rojo-Domínguez, A., García-Hernández, E.* (2020) Enthalpically-driven ligand recognition and cavity solvation of bovine odorant binding protein. Biophys. Chem. 257: 106315 (F.I. = 3.6, Q2; issn 0301-4622; eissn: 1873-4200; doi: 10.1016/j.bpc.2019.106315 ).
39. Ruiz-Blanco, Y.B.†, Avila-Barrientos, L.P.†, Hernández-García, E.†, Antunes, A., Agüero-Chapin, G.*, García-Hernández, E.* (2021) Engineering protein fragments via evolutionary and protein-protein interaction algorithms: De novo design of peptide inhibitors for FOF1-ATPsynthase. FEBS Lett. 595(2): 183-194. (F.I. = 3.9, Q1; issn 0014-5793; eissn: 1873-3468; doi: 10.1002/1873-3468.13988 ).
40. Labra-Núñez, A.†, Cofas-Vargas, L.F.†, Gutiérrez-Magdaleno, G.†, Gómez-Velasco, H.†, Rodríguez-Hernández, A., Rodríguez-Romero, A., García-Hernández, E.* (2021) Energetic and structural effects of the Tanford transition on ligand recognition of bovine -lactoglobulin. Arch. Biochem. Biophys. 699: 108750. (F.I. = 4.1, Q1; issn 0003-9861; eissn: 1096-0384; doi: 10.1016/j.abb.2020.108750 ).
41. Valdez-Cruz, N.A.*, García-Hernández, E., Espitia, C., Cobos-Marín, L., Altamirano, C., Bando-Campos, C.G., Cofas-Vargas, L.F.†, Coronado-Aceves, E.W., González-Hernández, R.A., Hernández-Peralta, P., Juárez-López, D., Ortega-Portilla, P.A., Restrepo-Pineda, S., Zelada-Cordero, P., Trujillo-Roldán, M.A.* (2021) Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatment. Microb. Cell Fact. 20:88. (F.I. = 6.4, Q1; eissn 1475-2859, doi: 10.1186/s12934-021-01576-5 ).
42. Avila-Barrientos, L.P.†, Cofas-Vargas, L.F.†, Agüero-Chapin, G., Hernández-García, E.†, Ruiz-Carmona, S., Valdez-Cruz, N.A., Trujillo-Roldán, M., Weber, J., Ruiz-Blanco, Y.B.†*, Barril, X., García-Hernández, E.* Computational design of inhibitors targeting the catalytic β subunit of Escherichia coli FOF1-ATP synthase. Antibiotics 11(5): 557 (F.I. = 5.2, Q1; eissn: 2079-6382; doi: 10.3390/antibiotics11050557).
43. Restrepo-Pineda, S., Sánchez-Puig, N., Pérez, N.O., García-Hernández, E., Valdez-Cruz, N.A., Trujillo-Roldán, M.* (2022) The pre-induction temperature affects the structural characteristics of recombinant HuGM-CSF inclusion bodies using a thermoinducible system. Appl. Microbiol. Biotechnol. 106: 2883–2902 (F.I. = 5.6, Q1; issn 0175-7598; eissn: 1432-0614, doi: 10.1007/s00253-022-11908-z ).
44. Restrepo-Pineda, S., Rosiles-Becerril, D., Vargas-Castillo, A.B., Avila-Barrientos, L.P.†, Luviano, A.†, Sánchez-Puig, N., García-Hernández, E., Pérez, N.O., Trujillo-Roldán, M., Valdez-Cruz, N.A. (2022) Induction temperature impacts the structure of recombinant HuGM-CSF inclusion bodies in thermoinducible E. coli. Elec. J. Biotech. 59: 94-106. (F.I. = 2.8, Q2, issn: 0717-3458 , eissn: 0717-3458, doi: 10.1016/j.ejbt.2022.08.004)
45. Cofas-Vargas, L.F.†, Mendoza-Espinosa, P.†, Ávila-Barrientos, L.P.†, Prada-Gracia, D., Riveros-Rosas, H., García-Hernández, E.* Exploring the druggability of the binding site of aurovertin, an exogenous allosteric inhibitor of FOF1-ATP synthase. Front. Pharmacol. 13: 1012008 (F.I. = 6.0, Q1; eissn: 1663-9812, doi: 10.3389/fphar.2022.1012008 ).
46. Titaux-Delgado, G., Lopez-Giraldo, A.E., Carrillo, E., Cofas-Vargas, L.F.†, Carranza, L., López-Vera, E., García-Hernández, E.*, del Rio-Portilla, E*. Beta-KTx14.3, a scorpion toxin, blocks the human potassium channel KCNQ1. Biochem Biophys Acta – Proteins & Proteomics 1871: 140906 (F.I. = 4.1, Q1; issn: 1570-9639, doi: 10.1016/j.bbapap.2023.140906).
47. Valdez-Cruz, N.A.*, Rosiles-Becerril, D., Martínez-Olivares, C.E., García-Hernández, E., Cobos-Marín, L., Garzón, D., López-Salas, F.E., Zavala, G., Luviano, A.†, Olvera, A., Alagón, A., Ramírez, O.T., Trujillo-Roldán, M.A.* (2024) Oral administration of a recombinant modified RBD antigen of SARS-CoV-2 as a possible immunostimulant for the care of COVID-19. Microb. Cell Fact. 23: 41 (F.I. = 6.4, Q1; eissn 1475-2859, doi: 10.1186/s12934 024 02320 5).
48. Medrano-Cerano, J.L.†, Cofas-Vargas, L.F.†, Leyva, E.†, Rauda-Ceja, J.A.†, Calderón-Vargas, M.† Cano-Sánchez, P., Titaux-Delgado, G., Melchor-Meneses, C.M., Hernández-Arana, A., del Río-Portilla, F.*, García-Hernández, E.* (2024) Decoding the mechanism governing the structural stability of wheat germ agglutinin and its isolated domains: A combined calorimetric, NMR, and MD simulation study. Protein Sci. 33(6): e5020 (F.I. = 8.1, Q1; eissn 1469896X, doi: 10.1002/pro.5020).
49. Prado-Romero, D.L., Saldívar-González, F.I., López-Mata, I., Laurel-García, P.A., Durán-Vargas, A.†, García-Hernández, E., Sánchez-Cruz, N., Medina-Franco, J.L.* (2024) De novo design of inhibitors of DNA methyltransferase 1: A critical comparison of ligand- and structure-based approaches. Biomolecules 14: 775 (F.I. = 4.8, Q1; ISSN: 2218-273X, doi: 10.3390/biom14070775).