Estudio de la regulación de los factores de virulencia por los sistemas sensores de quórum y el sistema Rsm en diferentes aislados de Pseudomonas aeruginosa.
Estudio de la producción de piocianina, su regulación génica por el sistema Rsm
Estudio de la respuesta autoprotectora ante la sobreproducción de piocianina en Pseudomonas aeruginosa.
Sobreproducción de fenazinas de interés médico e industrial utilizando a Pseudomonas aeruginosa ID4365

Publicaciones

1. Soto-Aceves, MP., Cocotl-Yañez, M., Merino, E., Castillo-Júarez, I., Cortés-López, H., González-Pedrajo, B., Díaz-Guerrero, M., Servín-González, L., Soberón-Chávez, G. Inactivation of the quorum-sensing transcriptional regulators LasR or RhlR does not supress the expression of virulence factors of Pseudomonas aeruginosa PAO1. Microbiology doi: 10.1099/mic.0.000778. (FI: 2.18)

2. Selene Reyes-García, Gloria Soberón-Chávez and Miguel Cocotl-Yañez*. 2020. The third quorum-sensing system of Pseudomonas aeruginosa: Pseudomonas Quinolone Signal and the enigmatic PqsE protein. Journal of Medical Microbiology. DOI 10.1099/jmm.0.001116 (FI: 2.15)

3. Cocotl-Yañez M*, Soto-Aceves MP, González-Valdez A, Servín-González L, Soberón-Chávez G. 2020. Virulence factors regulation by the quorum-sensing and Rsm Systems in the marine strain Pseudomonas aeruginosa ID4365, a natural mutant in lasR. FEMS Microbiology Letters. Jun 1;367(12):fnaa092 (FI: 1.98)

4. García-Reyes S, Soto-Aceves MP, Cocotl-Yañez M*, González-Valdez A, Servín-González L, Soberón-Chávez G. 2020. The outlier Pseudomonas aeruginosa strain ATCC 9027 harbors a detective LasR quorum-sensing transcriptional regulator. FEMS Microbiology Letters. Aug 1;367(16):fnaa122 (FI: 1.98)

5. Martínez-Ortíz I, Ahumada-Manuel C, Hsueh B, Guzman J, Moreno, S, Cocotl-Yañez M*, Water C, Zamorano-Sánchez D, Espin G, Nuñez C. 2020. Cyclic-di-GMP-mediated regulation of extracellular mannuronan C-5 epimerases is essential for cyst formation in Azotobacter vinelandii’. J Bact. Nov 19; 202(24):e00135-20 (FI: 3.21)

6. Soto-Aceves MP, Cocotl-Yañez M*, Servín-González L, Soberón-Chávez G. 2021. The Rhl quorum-sensing system is at the top of the regulatory hierarchy under phosphate-limiting conditions in Pseudomonas aeruginosa PAO1. J Bact. Feb 8;203 (5):e00475-20. (FI: 3.21)

7. Soberón-Chávez G, Soto-Aceves MP, González-Valdez A, Cocotl-Yañez M*. 2021. Rhamnolipids produced by Pseudomonas: from molecular genetics to the market. Microb Biotechnol. Jan;14(1): 136-146 (FI: 5.32)

8. Garcia-Reyes S, Cocotl-Yañez M, Soto-Aceves MP, González-Valdez A, Servín L, Soberón-Chávez G. 2021. The PqsR-independent quorum-sensing response of Pseudomonas aeruginosa ATCC 9027 outlier-strain reveals new insights on the PqsE effect on RhlR. Mol Microbiol. Oct;116(4):1113-1123. (FI: 3.5)

9. Montelongo-Martínez LF, Hernández-Méndez C, Muriel-Millan LF, Hernández-Estrada R, Fabian-Del Olmo MJ, González-Valdez A, Soberón-Chávez G, Cocotl-Yañez M. 2022. Unraveling the regulación of pyocyanin synthesis by RsmA through MvaU and RpoS in Pseudomonas aeruginosa ID4365. J Basic Microbiol. 2022;1–13. ) (FI-2.65)

10. Soto-Aceves MP, González-Váldez A, Cocotl-Yanez M, Soberón-Chávez G. 2022. Pseudomonas aeruginosa LasR overexpression leads to a ReaL-independent pyocyanin production inhibition in a low phosphate condition. Microbiology. Oct;168(10). doi: 10.1099/mic.0.001262. (FI: 2.8)

11. Muriel-Millán LF, Montelongo-Martínez LF, González-Valdez A, Bedoya-Perez LP, Cocotl-Yañez M, Soberón-Chávez G. The alternative sigma factor RpoS regúlales Pseudomonas aeruginosa quorum sensing response by repressing the pqsABCDE operon and activating vfr. Mol Microbiol. 2024 Feb;121(2):291-303 (FI:3.6)

12. Romero-González LE, Montelongo-Martínez LF, González-Valdez A, Quiroz-Morales SE, Cocotl-Yañez M, Franco-Cendejas R, Soberón-Chávez G, Pardo-Lopez L, Bustamante VH. Pseudomonas aeruginosa isolates from water samples of the gulf of Mexico show similar virulence properties but different antibiotic susceptibility profiles than clinical isolates. Int Jour of Microbiol. 2024, ID 6959403. .FI. 3.4

13. Montelongo-Martínez LF, Díaz-Guerrero M, Flores-Vega VR, Soto-Aceves MP, Rosales-Reyes R, Quiroz-Morales SE, González-Pedrajo B, Soberón-Chávez G, Cocotl-Yañez M*. The quorum sensing regulator RhlR positively controls the expression of the type III secretion system in Pseudomonas aeruginosa PAO1.
PLoS One. 2024 Aug 15;19(8):e0307174. doi: 10.1371/journal.pone.0307174. FI: 2.9

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx