Quimioinformática, inteligencia artificial y diseño de fármacos asistido por computadora con aplicaciones en dianas epigenéticas, productos naturales y péptidos.

Publicaciones

Resumen en Google Scholar: https://scholar.google.com/citations?user=xvyuVTYAAAAJ
Los factores de imacto se presentan al final de la lista de las publicaciones.
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1. López-López, E.*; Cerda-García-Rojas, C. M.; Medina-Franco, J. L.* Consensus Virtual Screening Protocol Towards the Identification of Small Molecules Interacting with the Colchicine Binding Site of the Tubulin-Microtubule System. Mol. Inf. 2022 en prensa.
2. Gómez-García, A.; Medina-Franco, J.L.* Progress and Impact of Latin American Natural Product Databases. Biomolecules 2022, 12, 1202.
3. Medina-Franco, J.L.* Chávez-Hernández, A. L.; López-López, E.; Saldívar-González, F.I. Chemical Multiverse: An Expanded View of Chemical Space. Mol. Inf. 2022, en prensa. DOI: 10.1002/minf.202200116
4. López-López, E. *; Fernández-de Gortari, E.; Medina-Franco, J.L.* Yes SIR! On the Structure-Inactivity Relationships in Drug Discovery. Drug Discovery Today 2022, 27, 2353-2362.
5. Medina-Franco, J.L.* López-López, E.; Andrade, E.; Ruiz-Azuara, L.; Frei, A.; Guan, D.; Zuegg, J.; Blaskovich M. A. T. Bridging informatics and medicinal inorganic chemistry: Towards a database of metallodrugs and metallodrug candidates. Drug Discovery Today 2022, 27, 1420-1430.
6. Medina-Franco, J.L.* López-López, E.; Martínez-Fernández, L.P.. 7-Aminoalkoxy-Quinazolines from Epigenetic Focused Libraries are Potent and Selective Inhibitors of DNA Methyltransferase. Molecules 2022, 27, 2892.
7. Saldívar-González, F.I.; Medina-Franco, J. L.* Approaches for Enhancing the Analysis of Chemical Space for Drug Discovery. Exp. Opin. Drug Discov. 2022 17: 789-798.
8. Saldívar-González, F.I.; Aldas-Bulos, V. D.; Medina-Franco, J. L.*; Plisson, F.* Natural Product Drug Discovery in the Artificial Intelligence Era. Chem. Sci. 2022, 13, 1526.
9. Flores-Padilla, E. A.; Juárez-Mercado, K. E.; Naveja, J. J; Kim, T. D.; Miranda-Quintana, R. A.; Medina-Franco JL.* Chemoinformatic Characterization of Synthetic Screening Libraries Focused on Epigenetic Targets. Mol. Inf. 2022, 41, 2100285
10. Dunn, T.; Seabra, G.; Kim, T.; Juárez-Mercado, K.; Li, C.; Medina-Franco, J.L.* Miranda-Quintana, R.* Diversity and Chemical Library Networks of Large Datasets. J. Chem. Inf. Model. 2022, 62, 2186-2201.
11. Medina-Franco, J.L.*; Sánchez-Cruz, N.; López-López, E.; Díaz-Eufracio, B.I. Progress on Open Chemoinformatic Tools for Expanding and Exploring the Chemical Space. J. Comput.-Aided Mol. Des. 2022, 36, 341-354.
12. Medina-Franco, J.L.*; López-López, E. The Essence and Transcendence of Scientific Publishing. Front. Res. Metr. Anal. 2022, 7, 822453.
13. Olmedo, D. A.; Durant-Archibold, A. A.; López-Pérez, J. L.; Medina-Franco, J. L.* Design and Diversity Analysis of Chemical Libraries in Drug Discovery. Com Chem. High Throughput Screen. 2022, aceptado.
14. Christoffersen, R. E.; Petke, J. D.; Howe, W. J.; Lajiness, M. S.; Johnson, M. A.;Agrafiotis, D.; Lee, P.; Bajorath, J.; Kuhn, L.; Goodwin, J.;Holloway, M. K.; Shanmugasundaram, V.; Doman, T. N.; Walters, W.P.; Schreyer, S.; Medina-Franco, J. L.; Martinez-Mayorga, K.; Restifo L. L. A tribute to Gerald (Gerry) M. Maggiora: Exemplary mentor, collaborator, colleague, and innovator. J. Comput.-Aided Mol. Des. 2022, en prensa.
15. Castro-Vazquez, D.; Sánchez-Carranza, J. N.; Alvarez, L.; Juárez-Mercado, K. E.; Sánchez-Cruz, N.; Medina-Franco, J. L.; Antunez-Mojica, M.; González-Maya, L. Methyl Benzoate and Cinnamate Analogs as Modulators of DNA Methylation in Hepatocellular Carcinoma. Chem. Biol. Drug Des. 2022, 100, 245-255.
16. Victoria-Muñoz, F.; Sánchez-Cruz, N.; Medina-Franco, J. L.; López-Vallejo, F. Cheminformatics analysis of molecular datasets of transcription factors associated with quorum sensing in Pseudomonas aeruginosa. RSC Adv. 2022, 12, 6783-6790.
17. Jiménez-Orozco, F.A; Galicia-Zapatero, S.; López-López, E.; Medina-Franco, J.L. León Cedeño, F.; Flores-García, M.; Mejia-Domínguez, A.; De la Peña-Díaz, A. Monosubstituted Coumarins Inhibit Epinephrine-induced Platelet Aggregation. Cardiovasc. Hematol. Agents Med. Chem. 2022, 20, 43-51.
18. Sánchez-Cruz, N.*; Medina-Franco, J.L.* Epigenetic target fishing with accurate machine learning models. J. Med. Chem. 2021, 64, 12, 8208-8220.
19. Chávez-Hernández, A. L.; Juárez-Mercado, K. E.; Saldivar-González, F. I.; Medina-Franco, J.L.* Towards the de novo design of HIV-1 protease inhibitors based on natural products. Biomolecules, 2021, 11, 1805.
20. Prado-Romero, D., Medina-Franco, J.L.* Advances in the exploration of the epigenetic relevant chemical space ACS Omega. 2021, 6, 22478–22486.
21. Muratov EN, Amaro R, Andrade CH, Brown N, Ekins S, Fourches D, Isayev O, Kozakov D, Medina-Franco JL, Merz KM, Oprea TI, Poroikov V, Schneider G, Todd MH, Varnek A, Winkler DA, Zakharov A, Cherkasov A, Tropsha A. A critical overview of computational approaches employed for COVID-19 drug Discovery. Chem. Soc. Rev. 2021, 90, 5121-9151.
22. Sánchez-Cruz, N.*; Medina-Franco, J.L.* Epigenetic Target Profiler: A Web Server to predict epigenetic targets of small molecules. J. Chem. Inf. Model. 2021, 61, 1550-1554.
23. López-López, E.; Bajorath, J.*; Medina-Franco, J. L.* Informatics for Chemistry, Biology, and Biomedical Sciences. J. Chem. Inf. Model. 2021, 61, 26-35.
24. Santibáñez-Morán, M. G.; Medina-Franco, J. L.* The Acid/Base Characterization of Molecules with Epigenetic Activity. ChemMedChem, 2021, 16, 1744-1753 [en volumen especial Chemical Epigenetics].
25. Juárez-Mercado, K. E.; Prieto-Martínez, F. D.; Sánchez-Cruz, N.; Peña-Castillo, A.; Prada-Gracia, D.; Medina-Franco, J. L.* Expanding the Structural Diversity of DNA Methyltransferase Inhibitors. Pharmaceuticals 2021, 14, 17.
26. Guerrero-Alonso, A.; Antunez-Mojica, M.; Medina-Franco, J. L.*. Chemoinformatic Analysis of Isothiocyanates: Their Impact In Nature and Medicine. Mol. Inf. 2021, 40, 2100172.
27. López-López, E.; Cerda-García-Rojas, C. M.*; Medina-Franco, J. L.* Tubulin Inhibitors: A Chemoinformatic Analysis Using Cell-Based Data. Molecules 2021, 26, 2483.
28. Medina-Franco, J.L.*; Martinez-Mayorga, K.; Fernández-de Gortari, E.; Kirchmair, J.; Bajorath, J. Rationality Over Fashion and Hype in Drug Design. F1000Research 2021, 10(Chem Inf Sci), 397.
29. Medina-Franco, J. L.* Computational Approaches for the Discovery and Development of Pharmacologically Active Natural Products. Biomolecules 2021, 11, 630.
30. Medina-Franco, J.L.* Expanding the Chemical Information Science Gateway. F1000Research 2021, 10(Chem Inf Sci), 294.
31. Medina-Franco, J.L.* Grand Challenges of Computer-Aided Drug Design: The Road Ahead. Front. Drug. Discov. 2021, 1, 728551.
32. Sánchez-Cruz, N.*; Medina-Franco, J.L.; Mestres, J.; Barril, X. Extended Connectivity Interaction Features: Improving Binding Affinity Prediction through Chemical Description Bioinformatics, 2021, 37, 1376-1382.
33. Prieto-Martínez, F. D., Fernández-de Gortari E., Medina-Franco, J. L.; L. Michel Espinoza-Fonseca. An in silico Pipeline for the Discovery of Multitarget Ligands: A Case Study for Epi-Polypharmacology Based on DNMT1/HDAC2 Inhibition. Artificial Intelligence in the Life Sciences 2021, 1, 100008.
34. Madariaga-Mazón, A.; Naveja, J. J.; Medina-Franco, J. L.; Noriega-Colima, K. O.; Martinez-Mayorga, K. DiaNat-DB: A Molecular Database of Antidiabetic Compounds from Medicinal Plants. RSC Adv. 2021, 11, 5172-5178.
35. Nuñez M. J.; Díaz-Eufracio, B. I.; Medina-Franco, J. L.; Olmedo D. A. Latin American Databases of Natural Products: Biodiversity and Drug Discovery Against SARS-CoV-2. RSC Adv. 2021, 11, 16051.
36. José A. Alatorre-Barajas; Eleazar Alcántar-Zavala; M. Graciela Gil-Rivas; Edgar Estrada-Zavala; Yadira Gochi-Ponce; Julio Montes-Ávila; Alberto Cabrera; Balter Trujillo-Navarrete; Yazmin Yorely Rivera-Lugo; Gabriel Alonso-Núñez; Edgar A. Reynoso-Soto; J. L. Medina-Franco. Synthesis of covalent bonding MWCNToligoethylene linezolid conjugates and theirantibacterial activity against bacterial strains. RSC Adv. 2021, 11, 28912.
37. Saldivar-González, F. I.; Medina-Franco, J. L. Nuevos usos a Medicamentos Existentes: el Reposicionamiento de Fármacos y su Importancia en Crisis Sanitarias. Revista Entorno UDLAP, 2021, 14, 4-15.
38. Ntie-Kang, F.; Telukunta, K. K.; Fobofou, S. A. T.; Chukwudi Osamor, V.; Egieyeh, S. A.; Valli, M.; Djoumbou-Feunang, Y.; Sorokina, M.; Stork, C.; Mathai, N.; Zierep, P.; Chávez-Hernández, A. L.; Duran-Frigola, M.; Babiaka, S. B.; Tematio Fouedjou, R.; Eni, D. B.; Akame, S.; Arreyetta-Bawak, A. B.; Ebob, O. T.; Metuge, J. A.; Bekono, B. D.; Isa, M. A.; Onuku, R.; Shadrack, D. M.; Musyoka, T. M.; Patil, V. M.; van der Hooft, J. J. J.; da Silva Bolzani, V.; Medina-Franco, J. L.; Kirchmair, J.; Weber, T.; Tastan Bishop, Ö.; Medema, M. H.; Wessjohann, L. A.; Ludwig-Müller, J., Computational Applications in Secondary Metabolite Discovery (CAiSMD): An online workshop. J. Cheminf. 2021, 13, 64.
39. Sessions, Z.; Sánchez-Cruz, N.; Prieto-Martínez, F. D.; Alves, V. M.; Santos Jr. H. S., Muratov, E.; Tropsha, A.; Medina-Franco, J.L.* Recent Progress on Cheminformatics Approaches to Epigenetic Drug Discovery. Drug Discovery Today. 2020, 25, 2268-2276.
40. Saldivar-González, F.I.; Medina-Franco, J.L.* Cheminformatics to Characterize Pharmacologically Active Natural Products. Biomolecules 2020, 10, 1566.
41. Naveja, J.J.*; Medina-Franco, J.L.* Consistent Cell-selective Analog Series as Constellation Luminaries in Chemical Space. Mol. Inf., 2020, 39, 2000061.
42. Chávez-Hernández, A.; Sánchez-Cruz, N.;* Medina-Franco, J.L.* Fragment Library of Natural Products and Compound Databases for Drug Discovery. Biomolecules 2020, 10, 1518.
43. Saldívar-González, F.I.; Huerta-García, C.S.; Medina-Franco, J.L. Chemoinformatics-Based Enumeration of Chemical Libraries: A Tutorial. J. Cheminformatics 2020, 12, 64.
44. Díaz-Eufracio,* B. I.; Palomino-Hernández, O.; Arredondo-Sánchez, A.; Medina-Franco, J.L.* D-Peptide Builder: D-Peptide Builder: A Web Service to Enumerate, Analyze, and Visualize the Chemical Space of Combinatorial Peptide Libraries. Mol. Inf. 2020, 39, 20000035.
45. Santibáñez-Morán, M. G.; López-López E.; Prieto-Martínez FD.; Sánchez-Cruz, N.; Medina-Franco, J.L.* Consensus Virtual Screening of Dark Chemical Matter and Food Chemicals Uncover Potential Inhibitors of SARS-CoV-2 main protease. RSC Adv. 2020, 10, 25089-25099.
46. López-López, E.; Rabal, O.; Oyarzabal, J.; Medina-Franco, J.L.* Towards the Understanding of the Activity of G9a Inhibitors: An Activity Landscape and Molecular Modeling Approach. J. Comput.-Aided Mol. Des. 2020, 34, 569-669.
47. Durán-Iturbide, N. A.; Díaz-Eufracio, B. I.*; Medina-Franco, J.L.* In Silico ADME/Tox Profiling of Natural Products: A Focus on BIOFACQUIM. ACS Omega, 2020, 5, 16076-16084.
48. Chávez-Hernández, A.; Sánchez-Cruz, N.;* Medina-Franco, J.L.* A Fragment Library of Natural Products and its Comparative Chemoinformatic Characterization. Mol. Inf., 2020, 39, 2000050.
49. López-López E.; Barrientos-Salcedo C.; Prieto-Martínez Fernando D.; Medina-Franco J.L.* In Silico Tools to Study Molecular Targets of Neglected Diseases: Inhibition of TcSir2rp3, an Epigenetic Enzyme of Trypanosoma cruzi. Adv. Protein Chem. Struct. Biol. 2020, 122, 203-229.
50. Santibáñez-Morán, M. G.; Medina-Franco, J.L.* Analysis of the Acid/Base Profile of Natural Products from Different Sources. Mol. Inf. 2020, 39, 1900099.
51. Maggiora, G.; Medina-Franco, J.L.; Iqbal, J.; Vogt, M.; Bajorath, J. From Qualitative to Quantitative Analysis of Activity and Property Landscapes J. Chem. Inf. Model. 2020, 12, 5873-5880.
52. Prieto-Martínez, F.D.; Medina-Franco J.L.* Current Advances on the Development of BET inhibitors: Insights from Computational Methods. Adv. Protein Chem. Struct. Biol. 2020, 122, 127-180.
53. Saldívar-González, F. I.; Lenci, E.; Calugi, L.; Medina-Franco, J.L.*; Trabocchi A.* Computational-Aided Design of a Library of Lactams through a Diversity-Oriented Synthesis Strategy. Bioorg. Med. Chem. 2020, 28, 115539.
54. Sánchez-Cruz, N.*; Pilón-Jiménez, B. A.; Medina-Franco, J.L.* Functional group and diversity analysis of BIOFACQUIM: AMexican natural product database. F1000Research 2020, 8(Chem Inf Sci), 2071.
55. Medina-Franco, J.L.* Towards a Unified Latin American Natural Products Database: LANaPD. Future Sci. OA, 2020, FSO597.
56. Brogi S.; Ramalho, T. C.; Kuca, K.; Medina-Franco, J. L.*; Valko, M. In Silico Methods for Drug Design and Discovery, Front. Chem., 2020, 8, 612.
57. Tran, T. D.; Ogbourne, S. M.; Brooks, P. R.; Sánchez-Cruz, N.; Medina-Franco, J. L.; Quinn, R. Q. Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components. Int. J. Mol. Sci. 2020, 21, 4988.
58. Al Sharie, A. H.; El-Elimat, T.; Al Zu’bi, Y. O.; Aleshawi, A. J.; Medina-Franco, J. L. Chemical Space and Diversity of Seaweed Metabolite Database (SWMD): A Cheminformatics Study. J. Mol. Graphics Modell. 2020, 100, 107702.
59. Medina-Franco, J.L.;* Cruz-Lemus, Y.; Percastre-Cruz, Y. Chemoinformatic Resources for Organometallic Drug Discovery. Computational Molecular Bioscience 2020, 10, 98324
60. Martinez-Mayorga, K.; Madariaga-Mazon, A.; Medina-Franco, J.L.; Maggiora. G. The impact of chemoinformatics on drug discovery in the pharmaceutical industry. Expert. Opin. Drug Discov. 2020, 15, 293-306.
61. Alcántar-Zavala, E.; Hernández-Guevara, E.; Ochoa-Terán, A.; Montes-Ávila, J.; Estrada-Zavala, E. A.; Salazar-Medina, A. J.; Alday, E.; Cabrera, A.; Aguirre, G.; Miranda-Soto, V.; Velazquez, C.; Díaz-Camacho, S. P.; Medina-Franco, J. L. Novel Linezolid Analogues with Antiparasitic Activity against Hymenolepis nana. Bioorg. Chem. 2020, 105, 104359.
62. Rocha-Garduño, G.; Hernández-Martinez, N. A.; Colín-Lozano, B.; Estrada-Soto, S.; Hernández-Núñez, E.; Prieto-Martinez, F. D.; Medina-Franco, J. L.; Chale-Dzul, J. B.; Moo-Puc, R.; Navarrete-Vazquez, G. Metronidazole and Secnidazole Carbamates: Synthesis, Antiprotozoal Activity and Molecular Dynamics Studies. Molecules, 2020, 20, 793.
63. García-Olaiz G.D,; Alcántar-Zavala, E.; Ochoa-Terán, A.; Cabrera, A.; Muñiz-Salazar R, Montes-Ávila J, Salazar-Medina AJ, Alday, E.; Velazquez, C.; Medina-Franco, J.L.; Laniado-Laboríngh R. Design, synthesis and evaluation of the antibacterial activity of new Linezolid dipeptide-type analogues. Bioorg. Chem. 2020, 95, 103483.
64. Jiménez-Arreola, B.S.; Aguilar-Ramírez, E.; Cano-Sánchez, P.; Morales-Jiménez, J.; González-Andrade, M.; Medina-Franco, J. L.; Rivera-Chávez. J. Dimeric phenalenones from Talaromyces sp. (IQ-313) Inhibit Hptp1b1-400: Insights into Mechanistic Kinetics from In Vitro and In Silico Studies. Bioorg. Chem. 2020, 101, 103893.
65. Medina-Franco, J.L.* Naveja, J.J.; López-López, E.; Reaching for the Bright StARs in Chemical Space. Drug Discovery Today 2019, 24, 2162-2169.
66. Naveja, J.J. *; Pilón-Jiménez B. A.; Bajorath, J. Medina-Franco, J.L.* A General Approach for Retrosynthetic Molecular Core Analysis. J. Cheminf. 2019, 11, 61.
67. Naveja, J.J.*; Medina-Franco, J.L.* Finding Constellations in Chemical Space Through Core Analysis. Front. Chem. 2019, 7, 510.
68. Saldívar-González, F.I.; Valli, M.; Andricopulo, A. D.; Vanderlan da Silva Bolzani, Medina-Franco, J.L.* Chemical diversity of NuBBE database: A chemoinformatic characterization J. Chem. Inf. Model. 2019, 59, 74-85.
69. Naveja, J.J.; Stumpfe, D.; Medina-Franco, J.L.*, Bajorath, J.* Exploration of target synergy in cancer treatment by cell-based screening assay and network propagation analysis J. Chem. Inf. Model. 2019, 59, 3072-3079.
70. Saldívar-González, F.I.; Lenci, E.; Trabocchi, A.; Medina-Franco, J.L.* Exploring the chemical space and the bioactivity profile of lactams: a chemoinformatic study. RSC Adv. 2019, 9, 27105.
71. Santibáñez-Morán, M. G.; Rico-Hidalgo, M. P.; Manallack, D. T.; Medina-Franco, J.L.* The acid/base profile of a large food chemical database. Mol. Inf. 2019, 38, 1800171.
72. López-López, E.; Naveja, J.J.; Medina-Franco, J.L.* DataWarrior: An evaluation of the open-source drug discovery tool. Expert Opin. Drug Discov. 2019, 14, 335-341.
73. Pilón-Jiménez, B. A.; Saldívar-González, F.I.; Díaz-Eufracio, B.I.; Medina-Franco, J.L.** BIOFACQUIM: A Mexican compound database of natural products. Biomolecules, 2019, 9, 31.
74. González-Medina, M.; Medina-Franco, J.L.* Chemical diversity of cyanobacterial compounds: A chemoinformatics analysis. ACS Omega 2019, 4, 6229-6237.
75. Saldívar-González, F.I.; Pilón-Jiménez, B. A.; Medina-Franco, J.L.* Chemical space of naturally occurring compounds. Physical Sciences Reviews, 2019, 4, 20180103.
76. Herrera-Vázquez, F.S.; Hernández-Luis, F.; Medina-Franco, J.L.* Quinazolines as inhibitors of chromatin-associated proteins in histones. Med. Chem. Res. 2019, 28, 395-416.
77. Medina-Franco, J.L.* New approaches for the discovery of pharmacologically-active natural compounds. Biomolecules, 2019, 9, 115.
78. Norinder, U.; Naveja, J.J.; López-López, E.; Mucs, D.; Medina-Franco, J.L. Conformal prediction of HDAC inhibitors. SAR QSAR Environ. Res. 2019, 30, 265-277.
79. Leroy, M.; Mélin, L.; LaPlante, S.R.; Medina-Franco, J.L.; Gagnon, A. Synthesis of NSC 106084 and NSC 14778 and evaluation of their DNMT inhibitory activity. Bioorg. Med. Chem. Lett. 2019, 29, 826-831.
80. Lenci, E.; Menchi, G.; Saldívar-Gonzalez, F.I.; Medina-Franco, J.L.; Trabocchi, A. Bicyclic acetals: scaffold analysis, biological activity and applications in the Diversity-Oriented Synthesis of natural product-inspired collections. Org. Biol. Chem. 2019, 17, 1037-1052.
81. Naveja, J.J.; Vogt, M.; Stumpfe, D.; Medina-Franco, J.L., Bajorath, J*. Systematic extraction of analog series from large compound collections using a new computational compound-core relationship method. ACS Omega 2019, 4, 1027-1032.
82. Martínez, R.; Zamudio, G.J.; Pretelin-Castillo, G.; Torres-Ochoa, R.O.; Medina-Franco, J.L.; Pinzón, C.I.; Miranda, M.S.; Hernández, E.; Alanís-Garza, B. Synthesis and antitubercular activity of new N-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]-(nitroheteroaryl)carboxamides. Heterocycl. Commun. 2019, 25, 52-59.
83. Sánchez-Cruz, N.; Medina-Franco, J.L.* Statistical-based database fingerprint: Chemical space dependent representation of compound databases J. Cheminformatics 2018, 10, 55.
84. López-López, E.; Prieto-Martínez, F.D.; Medina-Franco, J.L.* Activity landscape and molecular modeling to explore the SAR of dual epigenetic inhibitors: A Focus on G9a and DNMT1. Molecules 2018, 23, 3282.
85. Naveja J.J.; Norinder, U.; Mucs, D.; López-López, E.; Medina-Franco, J.L.* Chemical space, diversity and activity landscape analysis of estrogen receptor binders. RSC Adv. 2018, 8, 38229-38237.
86. Saldívar-González, F.I.; Gómez-García, A.; Chávez-Ponce de León, D.E.; Sánchez-Cruz, N.; Ruiz-Rios, J.; Pilón-Jiménez, B.A. Medina-Franco, J.L.* Inhibitors of DNA methyltransferases from natural sources: A computational perspective. Front. Pharmacol., 2018, 9, 1144.
87. Prieto-Martínez, F.D., Medina-Franco, J. L.* Flavonoids as putative epi-modulators: Insights into their binding mode with BRD4 bromodomain using molecular docking and dynamics. Biomolecules, 2018, 8, 61.
88. Naveja, J.J.; Rico-Hidalgo, M.P.; Medina-Franco, J. L.* Analysis of a large food chemical database: chemical space, diversity, and complexity. F1000Research 2018, 7(ChemInf Sci), 993.
89. Naveja, J.J.*; Medina-Franco, J. L.* Insights from pharmacological similarity of epigenetic targets in epi-polypharmacology. Drug Discovery Today 2018, 23, 141-150.
90. Cortés-Ruiz, E. M.; Palomino-Hernández, O.; Rodríguez Hernández, K. D.; Espinoza, B.; Medina-Franco, J. L.* Computational Methods to Discover Compounds for the Treatment of Chagas Disease. Advances in Protein Chemistry and Structural Biology 2018, 113, 119-142.
91. Oviedo-Osornio, C.I., Naveja, J.J., Medina-Franco, J.L.* Computational methods for epigenetic drug discovery: A focus on activity landscape modeling. Advances in Protein Chemistry and Structural Biology. 2018, 113, 65-83.
92. Díaz-Eufracio, B.I.; Naveja, J.J.; Medina-Franco, J.L.* Protein-protein interaction modulators for epigenetic therapies. Advances in Protein Chemistry and Structural Biology. 2018, 110, 65-84.
93. Díaz-Eufracio, B.I.; Palomino-Hernández, O.; Medina-Franco, J.L.* Exploring the chemical space of peptides for drug discovery: A focus on linear and cyclic penta-peptides. Mol Div. 2018, 22, 259-267.
94. Prieto-Martínez, F.D., Medina-Franco, J. L.* Charting the bromodomain BRD4: Towards the identification of novel inhibitors with molecular similarity and receptor mapping. Lett. Drug Des. & Discov., 2018, 15, 1002-1011.
95. Cabrera Velásquez A.; Huerta Hernández, L.; Chávez D.; Medina-Franco, J. L.* Molecular Modeling of Quinolone-Based Compounds as Potential Dual Inhibitors of HIV Reverse Transcriptase and Integrase. Computational Molecular Bioscience 2018, 8, 122-148.
96. Cabrera Velásquez A.; Huerta Hernández, L.; Chávez D.; Medina-Franco, J. L.* Molecular Modeling of Potential Dual Inhibitors of HIV Reverse Transcriptase and Integrase. Computational Molecular Bioscience 2018, 8, 1-41.
97. Prieto-Martínez, F.D., Medina-Franco, J. L.* Diseño de fármacos asistido por computadora: Cuando la informática, la química y el arte se encuentran. TIP Rev. Esp. Cienc. Quím. Biol. 2018, 21, 124-134.
98. Naveja, J. J; Oviedo-Osornio, C. I.; Trujillo-Minero, N. N.; Medina-Franco, J. L.* Chemoinformatics: A perspective from an academic setting in Latin America. Mol Divers., 2018, 22, 247-258.
99. Medina-Franco, J.L.*; Martinez-Mayorga, K. Uncovering activity cliff generators using distribution of SALI values. TIP Rev. Esp. Cienc. Quím. Biol., 2018, 21, 14-23.
100. Prieto-Martínez, F. D., Medina-Franco, J. L.* Molecular docking: Current advances and challenges. TIP Rev. Esp. Cienc. Quím. Biol., 2018, 21, 65-87.
101. Sánchez-Salgado, J.C.; Bilbao-Ramos, P.; Dea-Ayuela, M. A; Hernández-Luis, F.; Bolás-Fernández, F.; Medina-Franco, J.L., Rojas-Aguirre, Y.* Systematic search for benzimidazole compounds and derivatives with antileishmanial effects. Mol Div. 2018, 22, 779-790.
102. Dominguez-Gomez, G.; Chavez-Blanco, A., Medina-Franco, J. L.; Saldivar-Gonzalez, F.; Flores-Torrontegui, Y., Juarez Mandy, Díaz-Chávez, J.; Gonzalez-Fierro, A., Duenas-Gonzalez, A. Ivermectin as an inhibitor of cáncer stem-like cells. Molecular Medicine Reports 2018, 17, 3397-3403.
103. Jardínez-Vera, A. C.; Medina-Franco, J.L. QSAR modeling using quantum chemical descriptors of benzimidazoles analogues with antiparasitic properties. International Journal of Quantitative Structure-Property Relationships, 2018, 3, 61-79.
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Factores de impacto (2020) de revistas donde se ha publicado como autor de contacto:
Drug Discovery Today: 7.85
Journal of Medicinal Chemistry: 7.45
Expert Opinion on Drug Discovery: 6.01
Frontiers in Pharmacology: 5.81
Journal of Cheminformatics: 5.51
Journal of Chemical Information and Modeling: 4.96
Biomolecules: 4.88
Molecules: 4.41
Future Medicinal Chemistry: 3.81
Journal of Computer-Aided Molecular Design: 3.69
ACS Omega: 3.51
ChemMedChem: 3.45
Molecular Informatics: 3.35
RSC Advances: 3.36

Circuito de Posgrado, Ciudad Universitaria
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mdcbq@posgrado.unam.mx