Contacto
Campos de conocimiento
Bioinformática
Ciencias Genómicas
Genética y Fisiología Celular
Líneas de investigación
1.- Investigar la genómica funcional en las células epiteliales tímicas necesaria para la inducción de la tolerancia inmune central.
2.- Determinación de alteraciones epigenético-transcripcionales en cáncer
Publicaciones
•[Factor de Impacto: 25.5]
Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut.
Das A, Martinez-Ruiz GU, Bouladoux N, Stacy A, Moraly J, Vega-Sendino M, Zhao Y, Lavaert M, Ding Y, Morales-Sanchez A, Harly C, Seedhom MO, Chari R, Awasthi P, Ikeuchi T, Wang Y, Zhu J, Moutsopoulos NM, Chen W, Yewdell JW, Shapiro VS, Ruiz S, Taylor N, Belkaid Y, Bhandoola A. Immunity. 2024 May 14;57(5):1019-1036.e9. doi: 10.1016/j.immuni.2024.04.001. Epub 2024 Apr 26. PMID: 38677292.
•[Factor de Impacto: 11.7]
Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus development.
Martinez-Ruiz GU, Malin J, Zhao Y, Shissler SC, Cowan JE, Ding Y, Morales-Sanchez A, Ishikawa M, Lavaert M, Das A, Butcher D, Warner AC, Kallarakal M, Chen J, Kedei N, Kelly M, Brinster LR, Allman D, Bhandoola A. Sci Adv. 2023 Nov 17;9(46):eadg8126. doi: 10.1126/sciadv.adg8126. Epub 2023 Nov 15. PMID: 37967174
•[Factor de Impacto: 4.5]
Roles Played by YY1 in Embryonic, Adult and Cancer Stem Cells.
Martinez-Ruiz GU, Morales-Sanchez A, Pacheco-Hernandez AF. Stem Cell Rev Rep. 2021 Oct;17(5):1590-1606. doi: 10.1007/s12015-021-10151-9. Epub 2021 Mar 17. PMID: 33728560
•[Factor de Impacto: 2.6]
Camacho-Moctezuma B, Quevedo-Castillo M, Melendez-Zajgla J, Aquino-Jarquin G, Martinez-Ruiz GU. YY1 negatively regulates the XAF1 gene expression in prostate cancer. Biochem Biophys Res Commun. 2019 Jan 15;508(3):973-979. doi: 10.1016/j.bbrc.2018.12.056. Epub 2018 Dec 11. PubMed PMID: 30551877.
•[Factor de impacto: 2.6]
Requenez-Contreras JL, López-Castillejos ES, Hernández-Flores R, Moreno-Eutimio MA, Granados-Riveron JT, Martinez-Ruiz GU, Aquino-Jarquin G. MiR-138 indirectly regulates the MDR1 promoter by NF-κB/p65 silencing. Biochem Biophys Res Commun. 2017 Mar 11;484(3):648-655. doi: 10.1016/j.bbrc.2017.01.168.
•[Factor de impacto: 4.2]
Vazquez-Santillan K, Melendez-Zajgla J, Jimenez-Hernandez LE, Gaytan-Cervantes J, Muñoz-Galindo L, Piña-Sanchez P, Martinez-Ruiz G, Torres J, Garcia-Lopez P, Gonzalez-Torres C, Ruiz V, Avila-Moreno F, Velasco-Velazquez M, Perez-Tapia M, Maldonado V. NF-kappaΒ-inducing kinase regulates stem cell phenotype in breast cancer. Sci Rep. 2016 Nov 23;6:37340. doi: 10.1038/srep37340.
•[Factor de impacto: 0.15]
Victoria-Acosta G, Martinez-Archundia M, Moreno-Vargas L, Melendez-Zajgla J, Martinez-Ruiz G. “Is there something else besides the pro-apoptotic AVPI-segment in the Smac/DIABLO protein?” Bol Med Hosp Infant Mex 2016;73:365-71. doi: 10.1016/j.bmhimx.2016.10.004
•[Factor de impacto: 4.2]
Victoria-Acosta G, Jimenez-Hernandez L, Vazquez-Santillan K, Maldonado-Lagunas V, Martinez-Ruiz G, Melendez-Zajgla J. “Epigenetic silencing of the XAF1 gene is mediated by the loss of CTCF binding”. 2015, Sci Rep. 2015 Oct 7;5:14838. doi: 10.1038/srep14838.
•[Factor de impacto: 4.7]
Vazquez-Santillan K, Melendez-Zajgla J, Jimenez-Hernandez L, Martinez-Ruiz G, Maldonado-Lagunas V. NF-kB signaling in Cancer Stem Cells, Cell Oncol (Dordr). 2015 Aug 29.
