Bajo condiciones de estrés, tanto las mitocondrias como los cloroplastos de las plantas terrestres sufren cambios morfológicos que correlacionan con la disfunción de estos orgánulos. Las mitocondrias sufren una transición de la morfología y los cloroplastos generan estrómulos. En el laboratorio estudiamos las señales que inducen estos cambios utilizando a la planta modelo Arabidopsis thaliana en conjunto con herramientas de microscopía confocal y de bioenergética clásica.

Publicaciones

Mosqueda-Martínez E, Chiquete-Félix N, Castañeda-Tamez P, Ricardez-García C, Gutiérrez-Aguilar M, Uribe-Carvajal S, Mendez-Romero O. In Rhodotorula mucilaginosa, active oxidative metabolism increases carotenoids to inactivate excess reactive oxygen species. Front Fungal Biol. 2024 Sep 6;5:1378590.

García-Cerón, G., Solano-González, A. F., Bello-Cortés, I. H., Bonilla-Brunner, I. A., Araiza-Olivera, D., Gutiérrez-Aguilar, M., … García-Arrazola, R. (2024). Assessing the effect of foodborne endocrine disruptors exposure on methionine synthase activity in neuro-2a neuroblastoma cell lines. All Life, 17(1). https://doi.org/10.1080/26895293.2024.2407213

Gutiérrez-Aguilar M, Klutho PJ, Aguayo-Ortiz R, Song L, Baines CP. Endogenous complement 1q binding protein (C1qbp) regulates mitochondrial permeability transition and post-myocardial infarction remodeling and dysfunction. J Mol Cell Cardiol. 2024 Nov;196:1-11.

Gutiérrez-Mireles ER, Páez-Franco JC, Rodríguez-Ruíz R, Germán-Acacio JM, López-Aquino MC, Gutiérrez-Aguilar M. An Arabidopsis mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile. Plant Signal Behav. 2023 Dec 31;18(1):2271799.

Gutiérrez-Aguilar M. Mitochondrial calcium transport and permeability transition as rational targets for plant protection. Biochim Biophys Acta Bioenerg. 2020 Dec 1;1861(12):148288.

Ocampo-Hernández B, Gutiérrez Mireles ER, Gutiérrez-Aguilar M. Morphology and permeability transitions in plant mitochondria: Different aspects of the same event? Biochim Biophys Acta Bioenerg. 2022 Oct 1;1863(7):148586.

Ortiz-Jiménez DJ, López-Aquino CM, Flores-Herrera C, Preciado-Linares G, Gonzalez-Vizueth I, García-Arrazola R, Araiza-Olivera D, Gutiérrez-Aguilar M. A simple method for mitochondrial respiration and calcium uptake assessment in pollen tubes. MethodsX. 2019 Jul 25;6:1741-1746. doi: 10.1016/j.mex.2019.07.023. eCollection 2019. PubMed PMID: 31406686; PubMed Central PMCID: PMC6682373. CiteScore: 1.69

Torres-Torres EY, Montiel C, Araiza-Olivera D, Gutierrez-Aguilar M, Miquel Gimeno M, García-Arrazola R, Extracting endocrine disrupting compounds from infant formula using supercritical carbon dioxide, J Supercrit Fluid Volume 152, https://doi.org/10.1016/j.supflu.2019.104554 Factor de Impacto: 3.481

Hernández-Hernández KL, Tapia-Orozco N, Gimeno M, Espinosa-García AM, García-García JA, Araiza-Olivera D, Sánchez-Bartez F, Gracia-Mora I, Gutierrez-Aguilar M, García-Arrazola R. Exposure to bisphenol A: current levels
from food intake are toxic to human cells. Mol Biol Rep. 2019 Apr;46(2):2555-2559. doi: 10.1007/s11033-019-04666-1. Epub 2019 Feb 7. PubMed PMID: 30734171. Factor de Impacto: 1.889

Flores-Herrera C, Preciado-Linares G, Gonzalez-Vizueth I, Corona de la Peña N, Gutiérrez-Aguilar M. In situ assessment of mitochondrial calcium transport in tobacco pollen tubes. Protoplasma. 2019 Mar;256(2):503-509. doi:
10.1007/s00709-018-1316-z. Epub 2018 Oct 4. PubMed PMID: 30288611. Factor de Impacto: 2.633

Baines CP, Gutiérrez-Aguilar M. The still uncertain identity of the channel-forming unit(s) of the mitochondrial permeability transition pore. Cell Calcium. 2018 Jul;73:121-130. doi: 10.1016/j.ceca.2018.05.003. Epub 2018 May 16. Review. PubMed PMID: 29793100; PubMed Central PMCID: PMC5993635. Factor de Impacto: 3.932

Gutiérrez-Aguilar M. Commentary: Synthetic Ubiquinones Specifically Bind to Mitochondrial Voltage-Dependent Anion Channel 1 (VDAC1) in Saccharomyces cerevisiae Mitochondria. Front Mol Biosci. 2017 Mar 24;4:16. doi: 10.3389/fmolb.2017.00016. eCollection 2017. PubMed PMID: 28393069. Factor de Impacto: 3.565.

Corona de la Peña N, Gutiérrez-Aguilar M, Hernández-Reséndiz I, Marín-Hernández Á, Rodríguez-Enríquez S. Glycoprotein Ib activation by thrombin stimulates the energy metabolism in human platelets. PLoS One. 2017 Aug 17;12(8):e0182374. doi: 10.1371/journal.pone.0182374. eCollection 2017. PubMed PMID: 28817667; PubMed Central PMCID: PMC5560607. Factor de Impacto: 2.776

Hiemstra JA, Lee DI, Chakir K, Gutiérrez-Aguilar M, Marshall KD, Zgoda PJ, Cruz Rivera N, Dozier DG, Ferguson BS, Heublein DM, Burnett JC, Scherf C, Ivey JR, Minervini G, McDonald KS, Baines CP, Krenz M, Domeier TL, Emter CA. Saxagliptin and Tadalafil Differentially Alter Cyclic Guanosine Monophosphate (cGMP) Signaling and Left Ventricular Function in Aortic-Banded Mini-Swine. J Am Heart Assoc. 2016 Apr 20;5(4):e003277. doi: 10.1161/JAHA.116.003277. PubMed PMID: 27098966; PubMed Central PMCID: PMC4843537. Factor de Impacto: 5.117

Cabrera-Orefice A, Ibarra-García-Padilla R, Maldonado-Guzmán R,Guerrero-Castillo S, Luévano-Martínez LA, Pérez-Vázquez V, Gutiérrez-Aguilar M, Uribe-Carvajal S. The Saccharomyces cerevisiae mitochondrial unselective channel behaves as a physiological uncoupling system regulated by Ca2+, Mg2+, phosphate and ATP. J Bioenerg Biomembr. 2015 Dec;47(6):477-91. doi:10.1007/s10863-015-9632-x. Epub 2015 Nov 3. PubMed PMID: 26530988. Factor de Impacto: 2.548

Gutiérrez-Aguilar M, Baines CP. Structural mechanisms of cyclophilin D-dependent control of the mitochondrial permeability transition pore. Biochim Biophys Acta. 2015 Oct;1850(10):2041-7. doi: 10.1016/j.bbagen.2014.11.009. Epub 2014 Nov 13. Review. PubMed PMID: 25445707. Factor de Impacto: 3.681

Gutiérrez-Aguilar M, Uribe-Carvajal S. The mitochondrial unselective channel in Saccharomyces cerevisiae. Mitochondrion. 2015 May;22:85-90. doi:10.1016/j.mito.2015.04.002. Epub 2015 Apr 16. PubMed PMID: 25889953. Factor de Impacto: 3.449

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx