En mi laboratorio estamos interesados en el estudio de los procesos implicados en el desarrollo fetal de la corteza cerebral y el mesencéfalo, mediado por la activación de receptores acoplados a proteínas G, y microRNAs, en condiciones fisiológicas y patológicas. Para lo cual usamos modelos animales y celulares.
Lo anterior con el propósito de dilucidar cómo es que patologías maternas promueven la programación fetal de enfermedades neurológicas y neurodegenerativas en la infancia y el adulto.

Publicaciones

5. Ana G. Piña-Medina, Nestor F. Díaz, Anayansi Molina-Hernández, Ismael, Mancilla-Herrera, and Ignacio Camacho-Arroyo. (2020) Effects of progesterone on the cell number of gliomaspheres derived from human glioblastoma cell lines. Life Science doi.org/10.1016/j.lfs.2020.117536. Factor de Impacto 3.448
6. Avila-González, D., García-López, G., Díaz-Martínez, N. E., Flores-Herrera, H., Molina-Hernández, A., Portillo, W., Díaz, N. F. (2019) In Vitro Culture of Epithelial Cells from Different Anatomical Regions of the Human Amniotic Membrane. J. Vis. Exp. (153), e60551, doi:10.3791/60551. Factor de Impacto 1.108.
7. Néstor F. Díaz, Héctor Flores-Herrera, Guadalupe García-López and Anayansi Molina-Hernández. (2019) The H3R as a Potential Therapeutic Target for Obesity Treatment. CNS & Neurological Disorders - Drug Targets. 18:7. DOI: 10.2174/1871527318666190703094846. Factor de Impacto 2.761.
8. Berenice Márquez-Valadez, Guillermo Aquino-Miranda, Mijail-Oliver Quintero-Romero, Helena Papacostas-Quintanilla, Antonio Bueno-Nava, Carolina López-Rubalcava, Néstor Fabián Díaz, José-Antonio Arias-Montaño and Anayansi Molina-Hernández. (2019) The systemic administration of the histamine H1 receptor antagonist/inverse agonist chlorpheniramine to pregnant rats impairs the development of nigro-striatal dopaminergic neurons. Frontiers in Neuroscience. Apr 16; 13:360. Factor de Impacto 3.877. DOI: 10.3389/fnins.2019.00360.
9. Guadalupe García-López, Daniela Ávila-González, Irma Lydia García-Castro, Héctor Flores-Herrera, Anayansi Molina-Hernández, Wendy Portillo, Néstor Emmanuel Díaz-Martínez, Alejandro Sánchez-Flores, Jérôme Verleyen, Horacio Merchant-Larios, and Néstor Fabián Díaz. (2019) Pluripotency markers in tissue and cultivated cells in vitro of different regions of human amniotic epithelium. Experimental Cell Research. DOI: 10.1016/j.yexcr.2018.12.007. Factor de Impacto 3.274.
10. Daniela Avila-González, Omar Alarcón-Martínez, Guadalupe García-López, Néstor Emmanuel Díaz-Martínez, Guadalupe Razo-Aguilera, María Yolotzin Valdespino-Vázquez, Elsa Romelia Moreno-Verduzco, Eva Vega-Hernández, Juan Carlos Regalado-Hernández, Julio Francisco De la Jara-Díaz, Anayansi Molina-Hernández, Héctor Flores-Herrera, Wendy Portillo, and Néstor Fabián Díaz. (2019) Establishment of human embryonic stem cell line Amicqui-2 using poor-quality embryos from Mexican population. Stem Cell Research. DOI: 10.1016/j.scr.2018.101364. Factor de Impacto 3.9.
11. Berenice Márquez-Valadez, Rocío Valle-Bautista, Guadalupe García-López, Néstor Fabián Díaz and Anayansi Molina-Hernández. (2018) Maternal Diabetes and Fetal Programming Towards Neurological Diseases: Beyond Neural Tube Defects. Frontiers in Endocrinology. 9:664. DOI: 10.3389/fendo.2018.00664. Factor de Impacto 3.519.
12. Cristina M Sánchez-González, MD; Alfredo Castillo-Mora, MD; Itzel N Alvarado-Maldonado, MD; Carlos Ortega-González; Nayeli Martínez-Cruz, MD, M.Sc.; Lidia Arce-Sánchez, MD; Mabel Ramos-Valencia; Anayansi Molina-Hernández, PhD; Guadalupe Estrada-Gutiérrez, PhD; Salvador Espino Y Sosa; Yesenia Recio-López; Ruth Hernández-Sánchez, MD; Enrique Reyes-Muñoz, DSc. (2018) Reference intervals for hemoglobin A1c (HbA1c) in healthy Mexican pregnant women: A cross-sectional study. BMC Pregnancy and Childbirth. 18(424): 1-6. Online ISSN: 1471-2393. DOI: 10.1186/s12884-018-2057-x Factor de Impacto 3.331.
13. M.C. Álvarez‐Cabrera, E. Barrientos‐Galeana, A. Barrera‐García, M. Osorio‐Caballero, J.F. Acevedo, O. Flores‐Herrera, N.F. Díaz A. Molina‐Hernández, G. García‐López, and H. Flores‐Herrera. (2018) Secretion of heat shock ‐60, ‐70 kD protein, IL‐1β and TNFα levels in serum of a term normal pregnancy and patients with pre‐eclampsia development. Journal of Cellular and Molecular Medicine. 22: 5748–5752. DOI: 10.1111/jcmm.13824. Online ISSN:1582-4934. Factor de Impacto 4.302.
14. Gustavo Nieto-Alamilla, Juan Escamilla-Sánchez, María-Cristina López-Méndez, Anayansi Molina-Hernández, Agustín Guerrero-Hernández & José-Antonio Arias-Montaño. (2018) Differential expression and signaling of the human histamine H 3 receptor isoforms of 445 and 365 amino acids expressed in human neuroblastoma SH-SY5Y cells. Journal of Receptors and Signal Transduction. 30(1): 1-10. DOI: 10.1080/10799893.2018.1448995. ISSN:1079-9893, eISSN:1532-4281. Factor de Impacto 1.614.
15. Lamadrid M, Solís KH, Cruz-Reséndiz M, Pérez JE, García-López G, Flores-Herrera H,
Díaz NF, Perichart O, Reyes-Muñoz E, Arenas-Huertero F, Eguía-Aguilar P and Molina-Hernández A. (2018) Central nervous system development-related microRNAs levels increase in the serum of gestational diabetic women during the first trimester of pregnancy. Neuroscience Research. 130: 8-22. doi: 10.1016/j.neures.2017.08.003. ISSN: 01680102. Factor de Impacto 2.111.
16. Isela García-Gudiño, Eucario Yllescas-Medrano, Rolando Maida-Claros, Diana Soriano-
Becerril, Nestor F. Díaz, Guadalupe García-López, Anayansi Molina-Hernández, Oscar Flores-Herrera, Francisco J. Zavala-Díaz de la Serna, María del Rosario Peralta-Pérez y Héctor Flores-Herrera. (2017) Microbiological comparison of blood culture and amplification of 16S rDNA methods in combination with DGGE for detection of neonatal sepsis in blood samples. European Journal of Pediatrics. 177, 155–165. DOI 10.1007/s00431017-3036-3 ISSN: 0340-6199, eISSN: 1432-1076. Factor de Impacto 2.242.
17. Karina Helivier Solís, Laura Isabel Méndez, Guadalupe García-López, Néstor Fabián Díaz, Wendy Portillo, Mónica De Nova-Ocampo and Anayansi Molina-Hernández. (2017) The histamine H1 receptor participates in the increased dorsal telencephalic neurogenesis in embryos from diabetic rats. Frontiers in Neuroscience. Electronic ISSN: 1662453X. DOI: 0.3389/fnins.2017.00676. Factor de Impacto 3.877.
18. Nayeli Rivera-Ramírez, Wilber Montejo-López, María López, Anayansi Molina-Hernández, Agustín Guerrero-Hernández, Ubaldo García-Hernández, José-Antonio Arias-Montaño. (2016) Histamine H3 receptor activation stimulates IP3 formation and calcium mobilization in a subpopulation of rat striatal cultured neurons, but not in synaptosomes. Neurochem. Int. 101: 38-47. ISSN: 0197-0186. DOI: 10.1016/j.neuint.2016.10.005. Factor de Impacto 3.385.
19. Daniela Ávila-González, Guadalupe García-López, Irma Lydia García-Castro, Héctor Flores-Herrera, Anayansi Molina-Hernández, Wendy Portillo and Néstor Fabián Díaz. (2016) Capturing the ephemeral human pluripotent state. Developmental Dynamics. 245(7):762-73. DOI: 10.1002/dvdy.24405. ISSN 1058-8388. Factor de Impacto 2.376.
20. García-Castro IL, García-López G, Ávila-González D, Flores-Herrera H, Molina-Hernández A, Portillo W, Ramón-Gallegos E, Díaz NF. (2015) Markers of Pluripotency in Human Amniotic Epithelial Cells and Their Differentiation to Progenitor of Cortical
Neurons. PLoS One. Dec 31; 1-18. 10(12): e0146082. doi:
10.1371/journal.pone.0146082. eCollection 2015. eISSN 1932-6203. Factor de Impacto 3.23.
21. Sequeira K, Espejel-Núñez A, Vega-Hernández E, Molina-Hernández A, Grether González P. (2015) An increase in IL-1β concentrations in embryo culture-conditioned media obtained by in vitro fertilization on day 3 is related to successful implantation. J Assist Reprod Genet. Nov;32(11):1623-7. doi: 10.1007/s10815-015-0573-4. ISSN 1058-0468 y eISSN 1573-7330. Factor de Impacto 1.718.
22. Ávila-González D, Vega-Hernández E, Regalado-Hernández JC, De la Jara-Díaz JF,
García-Castro IL, Molina-Hernández A, Moreno-Verduzco ER, Razo-Aguilera G, Flores-Herrera H, Portillo W, Díaz-Martínez NE, García-López G, Díaz NF. (2015) Human amniotic epithelial cells as feeder layer to derive and maintain human embryonic stem cells from poor-quality embryos. Stem Cell Res. Sep;15(2):322-4. doi:
10.1016/j.scr.2015.07.006. ISSN: 1873-5061. Factor de Impacto 3.693.
23. García-López G, García-Castro IL, Avila-González D, Molina-Hernández A, Flores-Herrera H, Merchant-Larios H, Díaz-Martínez F. (2015) [Human amniotic epithelium (HAE) as a possible source of stem cells (SC)]. Gac Med Mex. Jan-Feb;151(1):66-74. ISSN 0016-3813. Factor de Impacto 0.274
24. M. Osorio-Caballero, C. Perdigón-Palacio, G. García-López, O. Flores-Herrera, S.
Olvera-Sánchez, I. Morales-Méndez, I. Sosa-González, J.F. Acevedo, A.M. GuzmánGrenfell, A. Molina-Hernández A, N.F. Díaz, H. Flores-Herrera. (2015) Escherichia coli-induced temporal and differential secretion of heatshock protein 70 and interleukin-1b by human fetal membranes in a two-compartment culture system. Placenta Mar;36(3):2629. doi: 10.1016/j. ISSN0143-4004. Factor de Impacto 3.693.
25. Hernández-Andrade E., Cortés-Camberos A. J., Díaz N. F., Flores-Herrera H., GarcíaLópez G., Rodríguez-Villanueva N.I., González-Jiménez M., Santamaría A., MolinaHernández A. (2015) Altered levels of brain neurotransmitter from new born rabbits with intra uterine restriction. Neuroscience Letters. 584:60–65. doi:10.1016/j.neulet.2014.09.051. ISSN: 0304-3940. Factor de Impacto 3.0.

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx