David es Investigador Titular en el Centro de Investigación sobre el Envejecimiento del Cinvestav Sede Sur, México. Utiliza técnicas bioinformáticas y de biología molecular para investigar el papel de las modificaciones epigenéticas en las histonas y el ARN en las enfermedades asociadas a la edad, como el cáncer y los trastornos metabólicos. Apasionado por la medicina de precisión, David desarrolla diagnósticos basados en ARN para la detección temprana de estas enfermedades.

Publicaciones

● Karla F Meza-Sosa*, David Valle-Garcia*, Hugo González-Conchillos, Tonali Blanco-Ayala, Alelí Salazar, Itamar Flores, Saúl Gómez-Manzo, Dinora Fabiola González Esquivel, Gonzalo Pérez de la Cruz, Benjamín Pineda, Verónica Pérez de la Cruz (2024) Molecular Mimicry between Toxoplasma gondii B-Cell Epitopes and Neurodevelopmental Proteins: An Immunoinformatic Approach. Biomolecules. 14(8):933. PMID: 39199321
*Equal contribution

● Paul Carrillo-Mora, Carlos Landa-Solís, David Valle-Garcia, Alexandra Luna-Angulo, Hamlet Avilés-Arnaut, Benjamín Robles-Bañuelos, Laura Sánchez-Chapul, Edgar Rangel-López (2024) Kynurenines and Inflammation: A Remarkable Axis for Multiple Sclerosis Treatment. Pharmaceuticals. 17(8):983. PMID: 39204088

● David Valle-Garcia, Verónica Pérez de la Cruz, Itamar Flores, Aleli Salazar, Benjamín Pineda, Karla F Meza-Sosa (2024) Use of microRNAs as diagnostic, prognostic, and therapeutic tools for glioblastoma. International Journal of Molecular Sciences. 25(5):2464. PMID: 38473710

● Aina Bellver-Sanchis, Pedro A Ávila-López, Iva Tic, David Valle-Garcia, Marta Ribalta-Vilella, Luis Labrador, Deb Ranjan Banerjee, Ana Guerrero, Gemma Casadesus, Coralie Poulard, Mercè Pallàs, Christian Griñán-Ferré (2024) Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128. Neural Regeneration Research. 19(11):2532–2542. PMID: 38526289

● Changying Guo*, Karla F Meza-Sosa*, David Valle-Garcia*, Guomeng Zhao, Kun Gao, Liting Yu, Hongying Zhang, Yeqing Chen, Liang Sun, Shira Rockowitz, Shouyu Wang, Sheng Jiang, Judy Lieberman (2023) The SET oncoprotein promotes estrogen-induced transcription by facilitating establishment of active chromatin. Proceedings of the National Academy of Sciences of the USA. 120(8):e2206878120. PMID: 36791099
*Equal contribution

● Sol Díaz de León-Guerrero, Jonathan Salazar-León, Karla F Meza-Sosa, David Valle-Garcia, Diana Aguilar-León, Gustavo Pedraza-Alva, Leonor Pérez-Martínez (2022) An enriched environment reestablishes metabolic homeostasis by reducing obesity-induced inflammation. Disease Models and Mechanisms. 15(6):dmm.048936. PMID: 35112705

● Ying Zhang, Xuemei Xie, Pourya Naderi Yeganeh, Dian-Jang Lee, David Valle-Garcia, Karla F Meza-Sosa, Caroline Junqueira, Jiayu Su, Hongbo R Luo, Winston Hide, Judy Lieberman (2021) Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown. Proceedings of the National Academy of Sciences of the USA. 118(9):e2022830118. PMID: 33627408

● Erdem Sendinc, David Valle-Garcia, Alan Jiao, Yang Shi (2020) Analysis of m6A RNA methylation in Caenorhabditis elegans. Cell Discovery. 6(1):47. PMID: 32695436

● Zulekha A Qadeer, David Valle-Garcia, Dan Hasson, Zhen Sun, April Cook, Christie Nguyen, Aroa Soriano, Anqi Ma, Lyra M Griffiths, Maged Zeineldin, Dan Filipescu, Luz Jubierre, Asif Chowdhury, Orla Deevy, Xiang Chen, David B Finkelstein, Armita Bahrami, Elizabeth Stewart, Sara Federico, Soledad Gallego, Fumiko Dekio, Mary Fowkes, David Meni, John M Maris, William A Weiss, Stephen S Roberts, Nai-Kong V Cheung, Jian Jin, Miguel F Segura, Michael A Dyer, Emily Bernstein (2019) ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures. Cancer cell. 36(5):512-527. PMID: 31631027

● Erdem Sendinc*, David Valle-Garcia*, Abhinav Dhall, Hao Chen, Telmo Henriques, Jose Navarrete-Perea, Wanqiang Sheng, Steven P Gygi, Karen Adelman, Yang Shi (2019) PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression. Molecular Cell. 75(3):620-630. PMID: 31279659
*Equal contribution

● Andrea K Byrum, Denisse Carvajal-Maldonado, Miranda C Mudge, David Valle-Garcia, Mona C Majid, Romil Patel, Mathew E Sowa, Steven P Gygi, J Wade Harper, Yang Shi, Alessandro Vindigni, Nima Mosammaparast (2019) Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function. Journal of Cell Biology. 218(2):422-432. PMID: 30602538

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx