Efectos Biológicos y Metabolismo del Calcitriol en la Salud y Enfermedad
Estudio los efectos antineoplásicos del calcitriol en el cáncer de mama y su potenciación por fármacos y productos naturales. Asimismo, el metabolismo placentario de la vitamina D y sus efectos en la hormonogénesis e inmunidad.

Publicaciones

1. Vargas-Castro R, Olmos-Ortiz A, García-Quiroz J, Avila E, Larrea F, Díaz L*. Calcitriol prevents SARS-CoV Spike-induced inflammation in human trophoblasts through downregulating ACE2 and TMPRSS2 expression. Journal of Steroid Biochemistry and Molecular Biology, 245: 106625, https://doi.org/10.1016/j.jsbmb.2024.106625 (2025). Factor de Impacto: 2.7
2. Cortes-Hernández U; Lizardi-Aguilera TM; Noriega-Mejía BJ; González-Macías J; García-Quiroz J; Díaz L; Larrea F; Avila E. Prostaglandin E2 suppresses KCNH1 gene expression and inhibits the proliferation of CaSki cervical cells through its four prostanoid PTGER subtypes. Gene 933, 148997 (2025). Factor de Impacto: 2.8
3. Zárate-Pérez A, Cruz-Cázares P, Ordaz-Rosado D, García-Quiroz J, León-Del-Rio A, Avila E, Milo-Rocha E, Díaz L*, García-Becerra*. The vitamin D analog EB1089 sensitizes triple-negative breast cancer cells to the antiproliferative effects of antiestrogens. Advances in Medical Sciences, 69(2):398-406 ISSN: 1896-1126, https://doi.org/10.1016/j.advms.2024.08.004 (2024). Factor de Impacto: 2.8
4. García-Uribe PA, Hernández-Silva G, Cecilia-Vega C, Ordaz-Rosado D, Morales A, Hernández-Pando R, García-Becerra R, Díaz L, García-Quiroz J, Barrera D, Larrea F, Chirinos M*. In vitro and in vivo evidence suggest that ulipristal acetate impacts endometrial compatibility for embryo implantation. Arch. Med. Res. 19;55(8):103026 (2024). Factor de Impacto: 4.7
5. Achounna AS, Ordaz-Rosado D, García-Quiroz J, Morales-Guadarrama G, Milo-Rocha E, Larrea F, Díaz L and García-Becerra R*. EB1089 Increases the Antiproliferative Response of Lapatinib in Combination with Antiestrogens in HER2-Positive Breast Cancer Cells. International Journal of Molecular Sciences, 25, (2024) 3165, https://doi.org/10.3390/ijms25063165. Factor de Impacto: 4.9
6. Vargas-Castro R, Olmos-Ortiz A, García-Quiroz J, Avila E, Larrea F, Díaz L*. Calcitriol downregulates ACE1/ACE2, Renin and TMPRSS2 gene expression in the human placenta. Preprints, 2023110402. https://doi.org/10.20944/preprints202311.0402.v1, (2023)
7. Vargas-Castro R, García-Becerra R, Díaz L, Avila E, Ordaz-Rosado D, Bernadez-Vallejo S, Cano-Colín S, Camacho J, Larrea F, García-Quiroz J*. Enhancing Tamoxifen Therapy with α-Mangostin: Synergistic Antiproliferative Effects on Breast Cancer Cells and Potential Reduced Endometrial Impact. Pharmaceuticals 16, 1576. https://doi.org/10.3390/ph16111576, (2023). Factor de Impacto 4.5
8. Morales-Guadarrama G, Méndez-Pérez EA, García-Quiroz J, Avila E, Ibarrra-Sánchez MJ, Esparza-López, J, García-Becerra R, Larrea F, Díaz L*. The Inhibition of the FGFR/PI3K/Akt Axis by AZD4547 Disrupts the Proangiogenic Microenvironment and Vasculogenic Mimicry Arising from the Interplay between Endothelial and Triple-Negative Breast Cancer Cells. International Journal of Molecular Sciences, 24, 13770; https://doi.org/10.3390/ijms241813770 (2023). Factor de Impacto: 4.9
9. Avila E*, Noriega-Mejía BJ, González-Macías J, Cortes-Hernández U, García-Quiroz J, García-Becerra R, Díaz L. The Preventive Role of the Vitamin D Endocrine System in Cervical Cancer. International Journal of Molecular Sciences, 24(10), 8665; https://doi.org/10.3390/ijms24108665, ISSN: 1422-0067 (2023). Factor de Impacto: 4.9
10. Jiménez-Escutia R, Vargas-Alcantar D, Flores-Espinosa P, Helguera-Repetto A, Villavicencio-Carrisoza O, Mancilla-Herrera I, Irles C, Torres-Ramos Y, Valdespino-Vazquez M, Velázquez-Sánchez P, Zamora-Escudero R, Islas-López M, Carranco-Salinas C, Díaz L, Zaga-Clavellina V, Olmos-Ortiz A*. High glucose promotes inflammation and weakens placental defenses against bacterial infections: protective role of insulin and metformin. International Journal of Molecular Sciences, 24(6):5243. doi: 10.3390/ijms24065243 ISSN: 1422-0067 (2023). Factor de Impacto: 4.9
11. Díaz L, Bernadez-Vallejo S, Vargas-Castro R, Avila E, Gómez-Ceja KA, García-Becerra R, Segovia-Mendoza M, Prado-Garcia H, Lara-Sotelo G, Camacho J, Larrea F, García-Quiroz J*. The phytochemical α-mangostin inhibits cervical cancer cell proliferation and tumor growth by downregulating E6/E7-HPV oncogenes and EAG1 gene expression. International Journal of Molecular Sciences, 24, 3055, https://doi.org/10.3390/ijms24033055 ISSN 1422-0067, (2023). Factor de Impacto: 4.9
12. García-Quiroz J, Vázquez-Almazán B, García-Becerra R, Díaz L, Avila E. The Interaction of Human Papillomavirus Infection and Prostaglandin E2 Signaling in Carcinogenesis: A Focus on Cervical Cancer Therapeutics. Cells, 11(16), 2528; https://doi.org/10.3390/cells11162528, ISSN 2073-4409, (2022) Factor de Impacto: 5.9
13. Morales-Guadarrama G, Méndez-Pérez EA, García-Quiroz J, Avila E, García-Becerra R, Zentella-Dehesa A, Larrea F, Díaz L*. Endothelium-Dependent Induction of Vasculogenic Mimicry in Human Triple-Negative Breast Cancer Cells Is Inhibited by Calcitriol and Curcumin. International Journal of Molecular Sciences, 23(14), 7659; https://doi.org/10.3390/ijms23147659, ISSN 1422-0067, (2022) Factor de Impacto: 4.9
14. Morales-Guadarrama G, Méndez-Pérez EA, García-Quiroz J, Avila E, Larrea F, Díaz L*. AZD4547 and calcitriol synergistically inhibited BT-474 cell proliferation while modified stemness and tumorsphere formation. J Steroid Biochem Mol Biol. 223, 106132, ISSN: 0960-0760, https://doi.org/10.1016/j.jsbmb.2022.106132 (2022)
15. Olmos-Ortiz A, Hernández-Pérez M, Flores-Espinosa MP, Sedano G, Helguera-Repetto A, Villavicencio-Carrisoza O, Valdespino-Vázquez MY, Flores-Pliego A, Irles C, Rivas-Santiago B, Moreno-Verduzco E, Díaz L, Zaga-Clavellina. Compartmentalized innate immune response of human fetal membranes against Escherichia coli choriodecidual infection. Int J Molec Sci 23, 2994, https://doi.org/10.3390/ijms23062994 (2022). Factor de Impacto: 5.92
16. Trujillo-Benítez D, Luna-Gutiérrez M, Ferro-Flores G, Ocampo-García B, Santos-Cuevas C, Bravo-Villegas G, Morales-Ávila E, Cruz-Nova P, Díaz-Nieto L, García-Quiroz J, Azorín-Vega E, Rosato A, Meléndez-Alafort L. Design, Synthesis and Preclinical Assessment of 99mTc-iFAP for In Vivo Fibroblast Activation Protein (FAP) Imaging. Molecules, 27, 264:1-18. https://doi.org/10.3390/molecules27010264 (2022). Factor de Impacto: 4.4
17. Santos-Martínez N, Díaz L, Ortíz V, Ordaz-Rosado D, Prado-Garcia H, Avila E, Larrea F, García-Becerra R. Calcitriol induces estrogen receptor α expression through direct transcriptional regulation and epigenetic modifications in estrogen receptor-negative breast cancer cells. Am J Cancer Res 11(12):5951-5964, ISSN:2156-6976 (2021). Factor de Impacto: 6.1
18. Segovia-Mendoza M, García-Quiroz J, Díaz L*, García-Becerra R*. Combinations of Calcitriol with Anticancer Treatments for Breast Cancer: An Update. Int J Molec Sci 22(23):12741, https://doi.org/10.3390/ijms222312741, (2021) ISSN 1661-6596. Factor de Impacto: 5.92
19. Olmos-Ortiz A†, Olivares-Huerta A†, García-Quiroz J, Avila E, Halhali A, Quesada-Reyna B, Larrea F, Zaga-Clavellina V*, Díaz L*. Cord Serum Calcitriol Inversely Correlates with Maternal Blood Pressure in Urinary Tract Infection-Affected Pregnancies: Sex-Dependent Immune Implications. Nutrients, 13 (9), 3114, https://doi.org/10.3390/nu13093114, (2021) ISSN 2072-6643. Factor de Impacto: 5.7
20. Olmos-Ortiz A, Flores-Espinosa MP, Díaz L, Velázquez P, Ramírez-Isarraraz C, Zaga-Clavellina V. Immunoendocrine Dysregulation during Gestational Diabetes Mellitus: the Central Role of the Placenta. Int J Molec Sci. 22, 8087, doi.org/10.3390/ijms22158087 (2021) ISSN 1661-6596. Factor de Impacto: 5.92
21. Morales-Guadarrama G, García-Becerra R, Méndez-Pérez E.A, García-Quiroz J, Avila E, Díaz L*. Vasculogenic Mimicry in Breast Cancer: Clinical Relevance and Drivers. Cells, 10(7), 1758; doi.org/10.3390/cells10071758, ISSN 2073-4409 (2021). Factor de Impacto: 6.6
22. García-Quiroz J, Cárdenas-Ochoa N, García-Becerra R, Morales-Guadarrama G, Méndez-Pérez E.A, Santos-Cuevas C, Ramírez-Nava G.J, Segovia-Mendoza M, Prado-Garcia H, Avila E, Larrea F, Díaz L*. Antitumoral effects of dovitinib in triple-negative breast cancer are synergized by calcitriol in vivo and in vitro. Preprints, 2021020063, doi: 10.20944/preprints202102.0063.v1, ISSN: 2310-287X; J Steroid Biochem Mol Biol. ISSN: 0960-0760, 214:105979, DOI: 10.1016/j.jsbmb.2021.105979 (2021). Factor de Impacto: 4.29
23. Zaga-Clavellina V, Diaz L, Olmos-Ortiz A, Godínez-Rubí M, Rojas-Mayorquín AE, Ortuño-Sahagún D. Central role of the placenta during viral infection: Immuno-competences and miRNA defensive responses. Biochim Biophys Acta Mol Basis Dis. 1867(10):166182. doi: 10.1016/j.bbadis.2021.166182, ISSN: 0925-4439 (2021). Factor de Impacto: 5.1
24. Lara-Sotelo G†, Díaz L†, García-Becerra R, Avila E, Prado-García H, Morales-Guadarrama G, Ibarra-Sánchez MJ, Esparza-López J, Larrea F, García-Quiroz J. The xanthone α-mangostin synergizes the antineoplastic effects of 5-fluorouracil in breast cancer. Processes, 9(3):458. DOI:10.3390/pr9030458 ISSN: 2227-9717 (2021). Factor de Impacto: 2.84
25. Olmos-Ortiz A, Olivares-Huerta A, García-Quiroz J, Zariñán T, Chavira R, Zaga-Clavellina V, Avila E, Halhali A, Durand M, Larrea F, Díaz L*. Placentas associated with female neonates from pregnancies complicated by urinary tract infections have higher cAMP content and cytokines expression than males. Am J Reprod Immunol, 27:e13434. doi: 10.1111/aji.13434 ISSN:1600-0897 (2021). Factor de Impacto: 3.88
26. Díaz L, Zambrano E, Flores ME, Contreras M, Crispín JC, Alemán G, Bravo C, Armenta A, Valdez J, Tovar A, Gamba G, Barrios J, Bobadilla N, Ethics in Experimental Research Involving the Use of Animals: The principle of 3R´s. Revista de Investigación Clínica - Clinical and Translational Investigation 7;73(4):199-209, doi: 10.24875/RIC.20000380 (2021) ISSN: 0034-8376. Factor de Impacto: 1.45
27. García-Quiroz J, García-Becerra R, Santos-Cuevas C, Ramírez-Nava J, Morales-Guadarrama G, Cárdenas-Ochoa N, Segovia-Mendoza M, Prado-Garcia H, Ordaz-Rosado D, Avila E, Olmos-Ortiz A, López S, Larrea F, Díaz L*. Synergistic Antitumorigenic Activity of Calcitriol with Curcumin or Resveratrol is Mediated by Angiogenesis Inhibition in Triple Negative Breast Cancer Xenografts. Cancers ISSN: 2072-6694 11:1739. doi.org/10.3390/cancers11111739, (2019). Factor de Impacto: 6.63
28. Olmos-Ortiz A, Flores-Espinosa P, Mancilla-Herrera I, Díaz L, Zaga-Clavellina V. Innate immune cells and TLR-dependent response at materno-fetal interface. Int J Molec Sci ISSN: 1422-0067 (2019), 20(15):3654. doi:10.3390/ijms20153654. Factor de Impacto: 5.92
29. Olmos-Ortiz A, Déciga-García M, Preciado-Martínez E, Flores-Espinosa P, Bermejo-Martínez L, Sosa-González IE, Quesada-Reyna B, Goffin V, Díaz L, Zaga-Clavellina V. Prolactin decreases LPS-induced inflammatory cytokines by inhibiting the TLR-4/NFκB signaling in human placenta. Molec Hum Reprod, ISSN: 1360-9947 (2019) 25(10):660-667. doi: 10.1093/molehr/gaz038. Factor de Impacto: 4.0
30. Martínez-Reza I, Díaz L, Barrera D, Segovia-Mendoza M, Pedraza-Sánchez S, Larrea F, García-Becerra R. Calcitriol inhibits the proliferation of triple negative breast cancer cells through a mechanism involving the proinflammatory cytokines IL-1β and TNF-α, Journal of Immunology Research ISSN: 2314-8861 (2019), Article ID 6384278, 1-11. doi.org/10.1155/2019/6384278. Factor de Impacto: 4.8
31. García-Quiroz J, González-González ME, Díaz L, Ordaz-Rosado D, Segovia-Mendoza M, Prado-Garcia H, Larrea F, García-Becerra R. Astemizole, an inhibitor of ether-à-go-go-1 potassium channel, increases the activity of the tyrosine kinase inhibitor gefitinib in breast cancer cells. Rev Invest Clin ISSN: 0034-8376 (2019) 71(3):186-194. Factor de Impacto: 1.45
32. Olmos-Ortiz A, García-Quiroz J, Halhali A, Avila E, Zaga-Clavellina V, Chavira-Ramirez R, García-Becerra R, Caldiño-Soto F, Larrea F, Díaz L*. Negative correlation between testosterone and TNF-α in umbilical cord serum favors a weakened immune milieu in the human male fetoplacental unit. J Steroid Biochem Mol Biol. ISSN: 0960-0760 (2019) 186:154-160. Factor de Impacto: 4.29

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx