En nuestro grupo de investigación trabajamos en la identificación de nuevos blancos y en el diseño de antibióticos mediante el estudio estructural, biofísico y bioquímico de proteínas participantes en procesos bacterianos clave usando como modelo principal al patógeno Mycobacterium tuberculosis.

Publicaciones

• Betancourt-Conde I, Avitia-Domínguez C, Hernández-Campos A, Castillo R, Yépez-Mulia L, Oria-Hernández J, Méndez ST, Sierra-Campos E, Valdez-Solana M, Martínez-Caballero S, et al. Benzimidazole Derivatives as New and Selective Inhibitors of Arginase from Leishmania mexicana with Biological Activity against Promastigotes and Amastigotes. Int J Mol Sci. 2021 Dec 19; 22(24):13613. doi: 10.3390/ijms222413613. Impact Factor: 6.208.
• Martínez-Caballero S, Kiran V. Mahasenan, Choon Kim, et al. Integrative Structural Biology of the Penicillin-Binding Protein-1 from Staphylococcus aureus, an Essential Component of the Divisome Machinery. CSBJ. 2021. doi.org/10.1016/j.csbj.2021.09.018. Impact Factor: 6.155
• Prieto-Castañeda A, Martínez-Caballero S*, Agarrabeitia AR, et al. First Lanthanide Complex for De Novo Phasing in Native Protein Crystallography at 1 Å Radiation. ACS Appl. Bio Mater. 2021. doi.org/10.1021/acsabm.1c00305.
• Flydal MI, Alcorlo-Pagés M, Johannessen FG, Martínez-Caballero S, et al. Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin. Proc Natl Acad Sci U S A. 2019;116(23):11229–11234. doi:10.1073/pnas.1902639116. Impact Factor: 12.799
• Bernardo-García N, Sánchez-Murcia PA, Espaillat A, Martínez-Caballero S, et al. Cold-induced aldimine bond cleavage by Tris in Bacillus subtilis alanine racemase. Org Biomol Chem. 2019;17(17):4350–4358. doi:10.1039/c9ob00223e. Impact Factor: 3.890
• Janardhanan J, Bouley R, Martínez-Caballero S, et al. The Quinazolinone Allosteric Inhibitor of PBP2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2019;63(5):e02637-18. Published 2019 Apr 25. doi:10.1128/AAC.02637-18. Impact Factor: 5.191
• Rued BE, Alcorlo M, Edmonds KA, Martínez-Caballero S, et al. Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae. mBio. 2019;10(1):e02622-18. Published 2019 Jan 29. doi:10.1128/mBio.02622-18. Impact Factor: 7.867
• Bartual SG, Alcorlo M, Martínez-Caballero S, Molina R, Hermoso JA. Three-dimensional structures of Lipoproteins from Streptococcus pneumoniae and Staphylococcus aureus. Int J Med Microbiol. 2018; 308(6):692–704. doi:10.1016/j.ijmm.2017.10.003. Impact Factor: 3.658
• Alcorlo M, Martínez-Caballero S*, Molina R, Hermoso JA. Carbohydrate recognition and lysis by bacterial peptidoglycan hydrolases. Curr Opin Struct Biol. 2017;44:87–100. doi:10.1016/j.sbi.2017.01.001. Impact Factor: 7.786

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx