Contacto
Campos de conocimiento
Bioquímica
Reconocimiento Molecular y Bioestructura
Líneas de investigación
Estructura y función de péptidos de toxinas de alacrán.
Síntesis Química de Péptidos
Publicaciones
Gurrola, G. B., Guijarro, J. I., Delepierre, M., Mendoza, R. L. L. Cid-Uribe, J. I., Coronas, F. V. Possani, L. D. (2019). Cn29, a novel orphan peptide found in the venom of the scorpion Centruroides noxius: Structure and function Toxicon, 167, 184-191.
Garcia-Guerrero,I.A., Carcamo-Noriega,E. Gomez-Lagunas,F., Gonzalez-Santillan,E. Zamudio,F.Z., Gurrola,G.B. Possani,L.D. (2020). Biochemical characterization of the venom from the Mexican scorpion Centruroides ornatus, a dangerous species to humans Toxicon, 173, 27-38.
Csoti,A., NajeraMeza,R.C., Bogar,F., Tajti,G., Szanto,T.G., Varga,Z., Gurrola,G.B., Toth,G.K., Possani,L.D. Panyi,G. (2022). sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity. Biochemical Pharmacology, 199, 115023.
Naseem,M.U., Gurrola-Briones,G., Romero-Imbachi,M.R., Borrego,J., CarcamoNoriega,E., Beltran-Vidal,J., Zamudio,F.Z., Shakeel,K., Possani,L.D., Panyi,G. (2023). Characterization and Chemical Synthesis of Cm39 (à-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K(+) Channel K(V)1.2 and Small- and Intermediate-Conductance Ca(2+)-Activated K(+) Channels K(Ca)2.2 and K(Ca)3.1. Toxins (Basel), 15 (1), 41.
Haji-Ghassemi,O., Chen,Y.S., Woll,K., Gurrola,G.B., Valdivia,C.R., Cai,W., Li,S., Valdivia,H.H., Van Petegem,F. (2023). Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation. Science Advances, 9 (21), eadf4936.
