Descubrimiento y síntesis de antimicrobianos utilizando blancos emergentes. Así mismo, se pretende el aislamiento y caracterización de enzimas poco estudiadas de bacterias multirresistentes para el diseño y síntesis de potenciales inhibidores.

Publicaciones

- Hernández-Vázquez, E.; Chávez-Riveros, A.; Romo-Pérez,A.; Ramírez-Apán, M. T.; Dueñas-González A.; Miranda L. D. Cytotoxic Activity and Structure-Activity Relationship of Triazole-Containing Bis-aryl Ether Macrocycles. ChemMedChem. 2018, 13, 1193–1209. DOI: 10.1002/cmdc.201800075. IF : 3.4

- Hernández-Vázquez, E.; González-García, M. C.; Miranda, L. D. Palladium-Catalyzed Olefin Migration and 7-endo-trig Cyclization of Dehydroalanines. Tetrahedron Lett. 2018, 59, 848–852. DOI: 10.1016/j.tetlet.2018.01.058. IF: 1.8

- Hernández-Vázquez, E; Young-Peralta, A.; Cerón-Romero, L.; García-Jimenez, S.; Estrada-Soto, S. Acute and Sub-acute Antidiabetic Studies of ENP-9, a New 1,5-Diarylpyrazole Derivative. J. Pharm. Pharmacol. 2018, 70, 1031–1039. DOI: 10.1111/jphp.12933. IF : 3.76

- Hernández-Vázquez E.; Chávez-Riveros, A.; Nieto-Camacho A.; Miranda, L. D. A Two-step Multicomponent Synthetic Approach and Anti-inflammatory Evaluation of N-Substituted 2-Oxopyrazines. ChemMedChem. 2019, 14, 132–146. DOI: 10.1002/cmdc.201800634. IF : 3.4

- Chávez-Riveros A.; Hernández-Vázquez E.; Nieto-Camacho, A.; Ramírez-Apán, M. T.; Miranda, L. D. Synthesis of Diphenylamine Macrocycles and their Anti-inflammatory Effect. Org. Biomol. Chem. 2019, 17, 1423–1435. DOI: 10.1039/C8OB03121E. IF: 3.2

- Amador-Sánchez, Y.; Hernández-Vázquez, E.; González-Mojica, N.; Ramírez-Apan, M. T.: Miranda, L. D. Diversity-Oriented Synthesis and Cytotoxic Screening of Fused Dihydropyrazin-2(1H)-ones through a Ugi 4-CR/Deprotection/Heck Sequence. Tetrahedron 2020, 76, 131383. DOI: 10.1016/j.tet.2020.131383. IF: 2.1

- Chávez-Riveros A.; Hernández-Vázquez E.; Ramírez-Trinidad, A.; Nieto-Camacho, A.; Miranda, L. D. Multicomponent synthesis and preliminary anti-inflammatory activity of lipophilic diphenylamines. Bioorg. Med. Chem. Lett. 2021, 38, 127860. DOI: 10.1016/j.bmcl.2021.127860. IF: 2.7

- Hernández-Vázquez E.; Amador-Sánchez, Y.; Cruz-Mendoza, M.; Ramírez-Apan, M. T.; Miranda, L. D. Multicomponent synthesis and anti-proliferative screening of biaryl triazole-containing cyclophanes. Bioorg. Med. Chem. Lett. 2021, 40, 127899. DOI: 10.1016/j.bmcl.2021.127899. IF: 2.7

- Auriostigue-Bautista, J. C.; Hernández-Vázquez, E.; Figueroa-Romero, J. L.; Castillo-Villanueva, A.; Miranda, L. D.; Oria-Hernández, J.; Reyes-Vivas, H. Discovery of Benzopyrrolizidines as Promising Antigiardiasic Agents. Front. Cell. Infect. Microbiol. 2022, 12. DOI: 10.3389/fcimb.2021.828100. IF: 6.4

- Chávez-Riveros, A.; Ramírez-Trinidad, A.; Hernández-Vázquez E.;Miranda, L. D. Expanding the structure-activity relationship of cytotoxic diphenyl macrocycles. Bioorg. Med. Chem. Lett. 2022, 62, 128628. DOI: 10.1016/j.bmcl.2022.128628. IF: 2.7

- Hernández-Vázquez, E.; Estrada-Soto, S.; Lumbreras-Zavala, N.; Mundo-Campuzano, M.; Chávez-Silva, F.; Hernández-Luis, F. Enhancing the antidiabetic and antidyslipidemic activity of a 1,5-diarylpyrazole by solid dispersion pre-formulation. Chem. Pap. 2022, 76, 5551–5560. DOI: 10.1007/s11696-022-02260-7. IF: 2.2

- Ramírez-Trinidad, A. Carillo-Jaimes, C, Rivera-Chávez, J.A. Hernández-Vázquez, E.. Synthesis and cytotoxic/antimicrobial screening of 3-alkenylimidazo[1,2-a]pyrimidines. Med. Chem. Res. 2023, 32, 144–157. DOI 10.1007/s00044-022-02997-6. IF: 2.6

- García, Mejía, C.D.; Hernández-Vázquez, E.; Hernández-Ibarra, J.; Tarbuck-Valle, A.; Ramírez-Apán. M.T. A regioselective synthesis of 3,4-diaryl-1H-pyrazoles through a 1,3-dipolar cycloaddition of tosylhydrazones and nitroalkenes. Org. Biomol. Chem. 2023, 21, 6205–6217. DOI 10.1039/D3OB00753G. IF: 3.2

Circuito de Posgrado, Ciudad Universitaria
Alcaldía Coyoacán, C.P. 04510, México, CDMX

55 5623 7006
mdcbq@posgrado.unam.mx