Contacto
Campos de conocimiento
Fisiología Molecular
Líneas de investigación
Caracterización fisiológica de la interacción toxinas-canales iónicos. Usando técnicas de electrofisiología, cultivo celular y biología molecular, estamos caracterizando la función de componentes del veneno de especies de alacranes de importancia médica, endémicas de México y de otros países.
Publicaciones
Valencia-Martinez,H., Olamendi-Portugal,T., Restano-Cassulini,R., Serrano-Posada,H., Zamudio,F., Possani,L.D., Riano-Umbarila,L., Becerril,B. (2022). Characterization of Four Medically Important Toxins from Centruroides huichol Scorpion Venom and Its Neutralization by a Single Recombinant Antibody Fragment. Toxins, 14 (6), 369.
Alamilla,J., Jimenez-Vargas,J.M., Galvan-Hernandez,A.R., Reyes-Mendez,M.E., Bermudez-Guzman,M.J., Restano-Cassulini,R., Olamendi-Portugal,T., Zamudio,F.Z., Possani,L.D., Valdez-Velazquez,L.L. (2021). Toxin Ct1a, from venom of Centruroides tecomanus, modifies the spontaneous firing frequency of neurons in the suprachiasmatic nucleus. Toxicon, 197, 114-125.
Beltran-Vidal,J., Carcamo-Noriega,E., Pastor,N., Zamudio-Zuniga,F., Guerrero-Vargas,J.A., Castano,S., Possani,L.D., Restano-Cassulini,R. (2021). Colombian Scorpion Centruroides margaritatus: Purification and Characterization of a Gamma Potassium Toxin with Full-Block Activity on the hERG1 Channel. Toxins (Basel), 13 (6), 407.
Benard-Valle,M., Neri-Castro,E.E., Yanez-Mendoza,M.F., Lomonte,B., Olvera,A., Zamudio,F., Restano-Cassulini,R., Possani,L.D., Jimenez-Ferrer,E., Alagon,A. (2020). Functional, proteomic and transcriptomic characterization of the venom from Micrurus browni browni: Identification of the first lethal multimeric neurotoxin in coral snake venom. Journal of Proteomics, 225, 103863.
Gomez-Ramirez,I.V., Riano-Umbarila,L., Olamendi-Portugal,T., Restano-Cassulini,R., Possani,L.D., Becerril,B. (2020). Biochemical, electrophysiological and immunological characterization of the venom from Centruroides baergi, a new scorpion species of medical importance in Mexico. Toxicon, 184, 10-18.
Mourao,C.B.F., Brand,G.D., Fernandes,J.P.C., Prates,M.V., Bloch,C., Barbosa,J.A.R.G., Freitas,S.M., Restano-Cassulini,R., Possani,L.D., Schwartz,E.F. (2020). Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides. Journal of Medicinal Chemistry, 63 (17), 9500?951.
