Contacto
Campos de conocimiento
Biología del Desarrollo
Biología Molecular y Celular de Microorganismos, Plantas y Animales
Líneas de investigación
Mi investigación tiene como objetivo principal comprender la formación, maduración y función de las células endocrinas, con particular interés en las células beta (β) que producen insulina, durante el desarrollo y en condiciones de estrés en el páncreas. De esta forma, al comprender los mecanismos subyacentes de la diferenciación y maduración de las células β se puede contribuir al desarrollo de nuevos enfoques para el tratamiento de diabetes.
Publicaciones
1. Akindehin S, Liskiewicz A, Liskiewicz D, Bernecker M, Garcia-Caceres C, Drucker D, Finan B, Grandl G, Gutgesell R, Hofmann S, Khalil A, Liu X, Cota P, Bakhti M, Czarnecki O, Bastidas-Ponce A, Lickert H, Kang L, Maity G, Novikoff A, Parlee S, Pathak E, Schriever S, Sterr M, Ussar S, Zhang Q, DiMarchi R, Tschöp M, Pfluger P, Douros J, Müller T. Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice. Mol Met (2024). https://doi.org/10.1016/j.molmet.2024.101915.
2. Grandl, G., Collden, G., Feng, Bhattacharya S, Klingelhuber F, Schomann L, Bilekova S, Ansarullah, Xu W, Far F, Tost M, Gruber T, Bastidas-Ponce A, Zhang Q, Novikoff A, Liskiewicz A, Liskiewicz D, Garcia-Caceres C, Feuchtinger A, Tschöp M, Krahmer N, Lickert H, Müller T. Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity. Nat Metab 6, 448–457 (2024). https://doi.org/10.1038/s42255-024-00991-3.
3. Cota P, Sehnaz Caliskan Ö, Bastidas-Ponce A, Jing C, Jaki J, Saber L, Czarnecki O, Taskin D, Blöchinger A, Kurth T, Sterr M, Burtscher I, Krahmer N, Lickert H, Bakhti M. Insulin regulates human pancreatic endocrine cell differentiation in vitro. Mol Metab (2024) https://doi.org/10.1016/j.molmet.2023.101853.
4. Liskiewicz, A., Khalil, A., Liskiewicz, D. Novikoff A, Grandl G, Maity-Kumar G, Gutgesell R, Bakhti M, Bastidas-Ponce A, Czarnecki O, Makris K, Lickert H, Feuchtinger A, Tost M, Coupland C, Ständer L, Akindehin S, Prakash S, Abrar F, Castelino R, He Y, Knerr P, Yang B, Hogendorf W, Zhang S, Hofmann S, Finan B, DiMarchi R, Tschöp M, Douros J, Müller T. Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice. Nat Metab 5, 2075–2085 (2023). https://doi.org/10.1038/s42255-023-00931-7.
5. Cota P, Saber L, Taskin D, Jing C, Bastidas-Ponce A, Vanheusden, Shahryari A, Sterr M, Burtscher I, Bakhti M, Lickert H. NEUROD2 function is dispensable for human pancreatic β cell specification. Front. Endocrinol 14, (2023). https://doi.org/10.3389/fendo.2023.1286590.
6. Hrovatin K, Bastidas-Ponce A, Bakhti M, Zappia L, Büttner M, Salinno C, Sterr M, Böttcher A, Migliorini A, Lickert H, Theis F. Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas. Nat Metab 5, 1615–1637 (2023). https://doi.org/10.1038/s42255-023-00876-x.
7. Bakhti, M.* Bastidas-Ponce, A.* et al., Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis. Nat Commun 13, 4540 (2022). (*First authors). https://doi.org/10.1038/s41467-022-31862-8.
8. Quarta C, Stemmer K, Novikoff A, Yang B, Klingelhuber F, Harger A, Bakhti M, Bastidas-Ponce A, Baugé E, Campbell J E, Capozzi M, Clemmensen C, Collden G, Cota P, DourosJ, Drucker D J, DuBois B, Feuchtinger A, Garcia-Caceres C, Grandl G, Hennuyer N, Herzig S, Hofmann S M, Knerr P J, Kulaj K, Lalloyer F, Lickert H, Liskiewicz A, Liskiewicz D, Maity G, Perez-Tilve D, Prakash S, Sanchez-Garrido M A, Zhang Q, Staels B, Krahmer N, DiMarchi R D, Tschöp M H, Finan B, Müller T D. GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice. Nat Metab 4, 1071–1083 (2022). https://doi.org/10.1038/s42255-022-00617-6.
9. Oppenländer L, Palit S, Stemmer K, Greisle T, Sterr M, Salinno C, Bastidas-Ponce A, Feuchtinger A, Böttcher A, Ansarullah, Theis FJ, Lickert H. Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes. Mol Metab. 2021 Sep 6;101330. doi: 10.1016/j.molmet.2021.101330.
10. Chhabra NF, Amend AL, Bastidas-Ponce A, Sabrautzki S, Tarquis-Medina M, Sachs S, Rubey M, Lorenz-Depiereux B, Feuchtinger A, Bakhti M, Lickert H, Przemech GKH, Hrabě de Angelis M. A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes. Mol Metab. 2021 Sep 3;101334. doi: 10.1016/j.molmet.2021.101334.
11. Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H. Inceptor counteracts insulin signalling in β-cells to control glycaemia. Nature. 2021 Feb; 590(7845):326-331. doi: 10.1038/s41586-021-03347-z
12. Salinno C, Büttner M, Cota P, Tritschler S, Tarquis-Medina M, Bastidas-Ponce A, Scheibner K, Burtscher I, Böttcher A, Theis FJ, Bakhti M, Lickert H. CD81 marks immature and dedifferentiated pancreatic β-cells. Mol Metab. 2021 Feb 11;49:101188. doi: 10.1016/j.molmet.2021.101188.
13. Nasteska D, Fine NHF, Ashford FB, Cuozzo F, Viloria K, Smith G, Dahir A, Dawson PWJ, Lai YC, Bastidas-Ponce A, Bakhti M, Rutter GA, Fiancette R, Nano R, Piemonti L, Lickert H, Zhou Q, Akerman I, Hodson DJ. PDX1LOW MAFALOW β-cells contribute to islet function and insulin release. Nat Commun. 2021 Jan 29;12(1):674. doi: 10.1038/s41467-020-20632-z.
14. Sachs S*, Bastidas-Ponce A*, Tritschler S*, Bakhti M, Böttcher A, Sánchez-Garrido MA, Tarquis-Medina M, Kleinert M, Fischer K, Jall S, Harger A, Bader E, Roscioni S, Ussar S, Feuchtinger A, Yesildag B, Neelakandhan A, Jensen CB, Cornu M, Yang B, Finan B, DiMarchi RD, Tschöp MH, Theis FJ, Hofmann SM, Müller TD, Lickert H. Targeted pharmacological therapy restores β-cell function for diabetes remission. Nature Metabolism. 2020 Feb;2(2):192-209. (*First authors). doi: 10.1038/s42255-020-0201-1.
15. Bakhti M, Scheibner K, Tritschler S, Bastidas-Ponce A, Tarquis-Medina M, Theis FJ, Lickert H. Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in vitro. Mol Metab. 2019 Dec; 30:16-29. doi: 10.1016/j.molmet.2019.09.005.
16. Salinno C, Cota P, Bastidas-Ponce A, Tarquis-Medina M, Lickert H, Bakhti M. β-cell maturation and identity in health and disease. Int J Mol Sci. 2019 Oct 30;20(21):5417. doi: 10.3390/ijms20215417.
17. Scheibner K, Bakhti M, Bastidas-Ponce A and Heiko Lickert. Wnt signaling: implications in endoderm development and pancreas organogenesis. Curr Opin Cell Biol. 2019 Aug 1; 61:48-55. doi: 10.1016/j.ceb.2019.07.002.
18. Bastidas-Ponce A*, Tritschler S*, Dony L, Scheibner K, Tarquis-Medina M, Salinno C, Schirge S, Burtscher I, Böttcher A, Theis FJ, Lickert H, Bakhti M. Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis. Development. 2019 Jun 17;146(12). (*First authors). doi: 10.1242/dev.173849.
19. Bakhti M, Bastidas-Ponce A, Lickert H. Sorting out fate determination. Dev Cell. 2019 Apr 8;49(1):1-3. doi: 10.1016/j.devcel.2019.03.020.
20. Fischer DS, Fiedler AK, Kernfeld EM, Genga RMJ, Bastidas-Ponce A, Bakhti M, Lickert H, Hasenauer J, Maehr R, Theis FJ. Inferring population dynamics from single-cell RNA-sequencing time series data. Nat Biotechnol. 2019 Apr;37(4):461-468. doi: 10.1038/s41587-019-0088-0.
