Contacto
Campos de conocimiento
Biotecnología
Microbiología Molecular
Líneas de investigación
Investigación Fundamental
Explorar la desregulación y la función de los ARN no codificantes (ncRNA) durante las infecciones por virus sincicial respiratorio (VSR) y alfavirus.
Investigación Aplicada
Desarrollar una plataforma de partículas similares a virus (VLP) con tropismo modificado para terapias de ARN.
Publicaciones
1. Sanchez-Martinez ZV, Alpuche-Lazcano SP, Stuible M, Akache B, Renner T, Hrapovic S, Blouin J, Cui K, Cho JY, Wang X, et al: SARS-CoV-2 spike-based virus-like particles incorporate influenza H1/N1 antigens and induce dual immunity in mice. Vaccine, 2024, 26:126463 Impact factor:4.5
2. Sanchez-Martinez ZV, Alpuche-Lazcano SP, Stuible M, Durocher Y: CHO cells for virus-like particle and subunit vaccine manufacturing. Vaccine, 2024, 42:10. Impact factor: 4.5
3. Alpuche-Lazcano SP Scarborough RJ, Gatignol A: MicroRNA and long non-coding RNAs during transcriptional regulation and latency of HIV and HTLV. Retrovirology, 2024, 21:5. Impact factor: 3.76
4. Alpuche-Lazcano SP, Stuible M, Akache B, Tran A, Kelly J, Hrapovic S, Robotham A, Haqqani A, Star A, Renner TM, et al: Preclinical evaluation of manufacturable SARS-CoV-2 spike virus-like particles produced in Chinese Hamster Ovary cells. Commun Med (Lond) 2023, 3:116. Impact factor: 5.4
5. Alpuche-Lazcano SP, Saliba J, Costa VV, Campolina-Silva GH, Marim FM, Ribeiro LS, Blank V, Mouland AJ, Teixeira MM, Gatignol A: Profound downregulation of neural transcription factor Npas4 and Nr4a family in fetal mice neurons infected with Zika virus. PLoS Negl Trop Dis 2021, 15:e0009425. Impact factor: DORA-N/A
Please read more here: https://plos.org/publish/dora/
6. Goguen RP, Del Corpo O, Malard CMG, Daher A, Alpuche-Lazcano SP, Chen MJ, Scarborough RJ, Gatignol A: Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters. Mol Ther Nucleic Acids 2021, 23:1020-1034. Impact factor: 6.5
7. Alpuche-Lazcano SP, Gatignol A: Chapter 37 - Cytopathicity and pathogenesis of Zika virus strains. In Zika Virus Biology, Transmission, and Pathology. Edited by Martin CR, Martin CJH, Preedy VR, Rajendram R: Academic Press; 2021: 397-407
8. Alpuche-Lazcano SP, McCullogh CR, Del Corpo O, Rance E, Scarborough RJ, Mouland AJ, Sagan SM, Teixeira MM, Gatignol A: Higher Cytopathic Effects of a Zika Virus Brazilian Isolate from Bahia Compared to a Canadian-Imported Thai Strain. Viruses 2018, 10. Impact factor: 4
9. Cerezo LG, Zárate CK, Alpuche-Lazcano S, et al. Molecular diagnosis for the detection of human metapneumovirus from viral isolates in pediatric patients with acute respiratory infection. Investigación en Discapacidad. 2016;5(2):88-95.
PREPRINTS
10. Alpuche-Lazcano SP, Dunkley ORS, Scarborough RJ, Daniels SM, Daher A, Truchi M, Estable MC, Mari B, Mouland AJ, Gatignol A: The sequestration of miR-642a-3p by a complex formed by HIV-1 Gag and human Dicer increases AFF4 expression and viral production. bioRxiv 2023:2023.2005.2024.542197.
